Phosphofructokinase 1 platelet isoform induces PD-L1 expression to promote glioblastoma immune evasion

Background Overexpression of PD-L1 is observed in many types of human cancer, including glioblastoma (GBM) and contributes to tumor immune evasion. In addition, GBM shows highly-activated aerobic glycolysis due to overexpression of phosphofructokinase 1 platelet isoform (PFKP), which the key enzyme...

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Veröffentlicht in:	Genes & genomics 2022-12, Vol.44 (12), p.1509-1517
Hauptverfasser:	Wang, Silu, Park, Su Hwan, Lim, Je Sun, Park, Yun-Yong, Du, Linyong, Lee, Jong-Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Analysis Animal Genetics and Genomics B7-H1 Antigen - genetics B7-H1 Antigen - metabolism Biomedical and Life Sciences Cell activation Enzymes Epidermal growth factor receptors ErbB Receptors - metabolism Genomes Glioblastoma Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma multiforme Glycolysis Human Genetics Humans Immune Evasion Life Sciences Lymphocytes T Metabolism Microbial Genetics and Genomics PD-L1 protein Phosphofructokinase Phosphofructokinase-1, Type C - genetics Phosphofructokinase-1, Type C - metabolism Phosphorylation Plant Genetics and Genomics Platelets Protein Isoforms - metabolism Research Article T cells Tumor cells β-Catenin
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