An Enthalpy-Balance Model for Timewise Evolution of Temperature during Wet Stirred Media Milling of Drug Suspensions

Purpose Nanosuspensions have been used for enhancing the bioavailability of poorly soluble drugs. This study explores the temperature evolution during their preparation in a wet stirred media mill using a coupled experimental–enthalpy balance approach. Methods Milling was performed at three levels o...

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Veröffentlicht in:Pharmaceutical research 2022-09, Vol.39 (9), p.2065-2082
Hauptverfasser: Guner, Gulenay, Elashri, Sherif, Mehaj, Mirsad, Seetharaman, Natasha, Yao, Helen F., Clancy, Donald J., Bilgili, Ecevit
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Sprache:eng
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