Mental health disorders are more common in patients with Hodgkin lymphoma and may negatively impact overall survival
Background Long‐term mental health outcomes were characterized in patients who were diagnosed with Hodgkin lymphoma (HL), and risk factors for the development of mental health disorders were identified. Methods Patients who were diagnosed with HL between 1997 and 2014 were identified in the Utah Can...
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| Veröffentlicht in: | Cancer 2022-10, Vol.128 (19), p.3564-3572 |
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| creator | Tao, Randa Chen, Yuji Kim, Seungmin Ocier, Krista Lloyd, Shane Poppe, Matthew M. Lee, Catherine J. Glenn, Martha J. Smith, Ken R. Fraser, Alison Deshmukh, Vikrant Newman, Michael G. Snyder, John Rowe, Kerry G. Gaffney, David K. Haaland, Ben Hashibe, Mia |
| description | Background
Long‐term mental health outcomes were characterized in patients who were diagnosed with Hodgkin lymphoma (HL), and risk factors for the development of mental health disorders were identified.
Methods
Patients who were diagnosed with HL between 1997 and 2014 were identified in the Utah Cancer Registry. Each patient was matched with up to five individuals from a general population cohort identified within the Utah Population Database, a unique source of linked records that includes patient and demographic data.
Results
In total, 795 patients who had HL were matched with 3575 individuals from the general population. Compared with the general population, patients who had HL had a higher risk of any mental health diagnosis (hazard ratio, 1.77; 95% confidence interval, 1.57–2.00). Patients with HL had higher risks of anxiety, depression, substance‐related disorders, and suicide and intentional self‐inflicted injuries compared with the general population. The main risk factor associated with an increased risk of being diagnosed with mental health disorders was undergoing hematopoietic stem cell transplantation, with a hazard ratio of 2.06 (95% confidence interval, 1.53–2.76). The diagnosis of any mental health disorder among patients with HL was associated with a detrimental impact on overall survival; the 10‐year overall survival rate was 70% in patients who had a mental health diagnosis compared with 86% in those patients without a mental health diagnosis (p |
| doi_str_mv | 10.1002/cncr.34359 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2697366487</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2697366487</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3349-99da7df3fb8f7927f35b69dda042668fe27abd7f186398990a36f23bbddd26853</originalsourceid><addsrcrecordid>eNp90U1r3DAQBmARWsg2zSW_QJBLKTiRJVuyjmVpPiAfUBrITYwtKatEslzJu8H_Pkq2px560aDhmWHgReikJmc1IfR8GId0xhrWygO0qokUFakb-gmtCCFd1Tbs8RB9yfm5fAVt2QrNt2acweONAT9vsHY5Jm1SxpAMDrE8QwwhjtiNeILZFZ3xqyv0Kuqnl9L1S5g2MQCGUeMACx7NU4E74xfswgTDjOPOJPAe523auR34r-izBZ_N8d96hB4ufv5eX1U395fX6x831cBYIyspNQhtme07KyQVlrU9l1oDaSjnnTVUQK-FrTvOZCclAcYtZX2vtaa8a9kR-rbfO6X4Z2vyrILLg_EeRhO3WVEuBeO86UShp__Q57hNY7lOUUGkbNq2k0V936shxZyTsWpKLkBaVE3UewDqPQD1EUDB9R6_Om-W_0i1vlv_2s-8Af4wijo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2709945589</pqid></control><display><type>article</type><title>Mental health disorders are more common in patients with Hodgkin lymphoma and may negatively impact overall survival</title><source>Wiley Free Content</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Tao, Randa ; Chen, Yuji ; Kim, Seungmin ; Ocier, Krista ; Lloyd, Shane ; Poppe, Matthew M. ; Lee, Catherine J. ; Glenn, Martha J. ; Smith, Ken R. ; Fraser, Alison ; Deshmukh, Vikrant ; Newman, Michael G. ; Snyder, John ; Rowe, Kerry G. ; Gaffney, David K. ; Haaland, Ben ; Hashibe, Mia</creator><creatorcontrib>Tao, Randa ; Chen, Yuji ; Kim, Seungmin ; Ocier, Krista ; Lloyd, Shane ; Poppe, Matthew M. ; Lee, Catherine J. ; Glenn, Martha J. ; Smith, Ken R. ; Fraser, Alison ; Deshmukh, Vikrant ; Newman, Michael G. ; Snyder, John ; Rowe, Kerry G. ; Gaffney, David K. ; Haaland, Ben ; Hashibe, Mia</creatorcontrib><description>Background
Long‐term mental health outcomes were characterized in patients who were diagnosed with Hodgkin lymphoma (HL), and risk factors for the development of mental health disorders were identified.
Methods
Patients who were diagnosed with HL between 1997 and 2014 were identified in the Utah Cancer Registry. Each patient was matched with up to five individuals from a general population cohort identified within the Utah Population Database, a unique source of linked records that includes patient and demographic data.
Results
In total, 795 patients who had HL were matched with 3575 individuals from the general population. Compared with the general population, patients who had HL had a higher risk of any mental health diagnosis (hazard ratio, 1.77; 95% confidence interval, 1.57–2.00). Patients with HL had higher risks of anxiety, depression, substance‐related disorders, and suicide and intentional self‐inflicted injuries compared with the general population. The main risk factor associated with an increased risk of being diagnosed with mental health disorders was undergoing hematopoietic stem cell transplantation, with a hazard ratio of 2.06 (95% confidence interval, 1.53–2.76). The diagnosis of any mental health disorder among patients with HL was associated with a detrimental impact on overall survival; the 10‐year overall survival rate was 70% in patients who had a mental health diagnosis compared with 86% in those patients without a mental health diagnosis (p < .0001).
Conclusions
Patients who had HL had an increased risk of various mental health disorders compared with a matched general population. The current data illustrate the importance of attention to mental health in HL survivorship, particularly for patients who undergo therapy with hematopoietic stem cell transplantation.
Hodgkin lymphoma survivors had an increased risk of mental health disorders, and undergoing stem cell transplantation was the only treatment‐related risk factor. Survivors who had a mental health disorder had worse overall survival compared with those who did not develop a mental health disorder.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.34359</identifier><language>eng</language><publisher>Atlanta: Wiley Subscription Services, Inc</publisher><subject>Anxiety ; Confidence intervals ; depression ; Diagnosis ; Disorders ; Health hazards ; Health risks ; Hematopoietic stem cells ; Hodgkin lymphoma ; Hodgkin's lymphoma ; Lymphoma ; Mental disorders ; Mental health ; Oncology ; Patients ; Population ; Risk analysis ; Risk factors ; Stem cell transplantation ; Stem cells ; Suicide ; Survival ; survivorship ; Transplantation</subject><ispartof>Cancer, 2022-10, Vol.128 (19), p.3564-3572</ispartof><rights>2022 American Cancer Society.</rights><rights>2022 American Cancer Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3349-99da7df3fb8f7927f35b69dda042668fe27abd7f186398990a36f23bbddd26853</citedby><cites>FETCH-LOGICAL-c3349-99da7df3fb8f7927f35b69dda042668fe27abd7f186398990a36f23bbddd26853</cites><orcidid>0000-0002-4235-7652 ; 0000-0001-9379-4732 ; 0000-0003-2587-8955 ; 0000-0002-5752-1611</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.34359$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.34359$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids></links><search><creatorcontrib>Tao, Randa</creatorcontrib><creatorcontrib>Chen, Yuji</creatorcontrib><creatorcontrib>Kim, Seungmin</creatorcontrib><creatorcontrib>Ocier, Krista</creatorcontrib><creatorcontrib>Lloyd, Shane</creatorcontrib><creatorcontrib>Poppe, Matthew M.</creatorcontrib><creatorcontrib>Lee, Catherine J.</creatorcontrib><creatorcontrib>Glenn, Martha J.</creatorcontrib><creatorcontrib>Smith, Ken R.</creatorcontrib><creatorcontrib>Fraser, Alison</creatorcontrib><creatorcontrib>Deshmukh, Vikrant</creatorcontrib><creatorcontrib>Newman, Michael G.</creatorcontrib><creatorcontrib>Snyder, John</creatorcontrib><creatorcontrib>Rowe, Kerry G.</creatorcontrib><creatorcontrib>Gaffney, David K.</creatorcontrib><creatorcontrib>Haaland, Ben</creatorcontrib><creatorcontrib>Hashibe, Mia</creatorcontrib><title>Mental health disorders are more common in patients with Hodgkin lymphoma and may negatively impact overall survival</title><title>Cancer</title><description>Background
Long‐term mental health outcomes were characterized in patients who were diagnosed with Hodgkin lymphoma (HL), and risk factors for the development of mental health disorders were identified.
Methods
Patients who were diagnosed with HL between 1997 and 2014 were identified in the Utah Cancer Registry. Each patient was matched with up to five individuals from a general population cohort identified within the Utah Population Database, a unique source of linked records that includes patient and demographic data.
Results
In total, 795 patients who had HL were matched with 3575 individuals from the general population. Compared with the general population, patients who had HL had a higher risk of any mental health diagnosis (hazard ratio, 1.77; 95% confidence interval, 1.57–2.00). Patients with HL had higher risks of anxiety, depression, substance‐related disorders, and suicide and intentional self‐inflicted injuries compared with the general population. The main risk factor associated with an increased risk of being diagnosed with mental health disorders was undergoing hematopoietic stem cell transplantation, with a hazard ratio of 2.06 (95% confidence interval, 1.53–2.76). The diagnosis of any mental health disorder among patients with HL was associated with a detrimental impact on overall survival; the 10‐year overall survival rate was 70% in patients who had a mental health diagnosis compared with 86% in those patients without a mental health diagnosis (p < .0001).
Conclusions
Patients who had HL had an increased risk of various mental health disorders compared with a matched general population. The current data illustrate the importance of attention to mental health in HL survivorship, particularly for patients who undergo therapy with hematopoietic stem cell transplantation.
Hodgkin lymphoma survivors had an increased risk of mental health disorders, and undergoing stem cell transplantation was the only treatment‐related risk factor. Survivors who had a mental health disorder had worse overall survival compared with those who did not develop a mental health disorder.</description><subject>Anxiety</subject><subject>Confidence intervals</subject><subject>depression</subject><subject>Diagnosis</subject><subject>Disorders</subject><subject>Health hazards</subject><subject>Health risks</subject><subject>Hematopoietic stem cells</subject><subject>Hodgkin lymphoma</subject><subject>Hodgkin's lymphoma</subject><subject>Lymphoma</subject><subject>Mental disorders</subject><subject>Mental health</subject><subject>Oncology</subject><subject>Patients</subject><subject>Population</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Suicide</subject><subject>Survival</subject><subject>survivorship</subject><subject>Transplantation</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp90U1r3DAQBmARWsg2zSW_QJBLKTiRJVuyjmVpPiAfUBrITYwtKatEslzJu8H_Pkq2px560aDhmWHgReikJmc1IfR8GId0xhrWygO0qokUFakb-gmtCCFd1Tbs8RB9yfm5fAVt2QrNt2acweONAT9vsHY5Jm1SxpAMDrE8QwwhjtiNeILZFZ3xqyv0Kuqnl9L1S5g2MQCGUeMACx7NU4E74xfswgTDjOPOJPAe523auR34r-izBZ_N8d96hB4ufv5eX1U395fX6x831cBYIyspNQhtme07KyQVlrU9l1oDaSjnnTVUQK-FrTvOZCclAcYtZX2vtaa8a9kR-rbfO6X4Z2vyrILLg_EeRhO3WVEuBeO86UShp__Q57hNY7lOUUGkbNq2k0V936shxZyTsWpKLkBaVE3UewDqPQD1EUDB9R6_Om-W_0i1vlv_2s-8Af4wijo</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Tao, Randa</creator><creator>Chen, Yuji</creator><creator>Kim, Seungmin</creator><creator>Ocier, Krista</creator><creator>Lloyd, Shane</creator><creator>Poppe, Matthew M.</creator><creator>Lee, Catherine J.</creator><creator>Glenn, Martha J.</creator><creator>Smith, Ken R.</creator><creator>Fraser, Alison</creator><creator>Deshmukh, Vikrant</creator><creator>Newman, Michael G.</creator><creator>Snyder, John</creator><creator>Rowe, Kerry G.</creator><creator>Gaffney, David K.</creator><creator>Haaland, Ben</creator><creator>Hashibe, Mia</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4235-7652</orcidid><orcidid>https://orcid.org/0000-0001-9379-4732</orcidid><orcidid>https://orcid.org/0000-0003-2587-8955</orcidid><orcidid>https://orcid.org/0000-0002-5752-1611</orcidid></search><sort><creationdate>20221001</creationdate><title>Mental health disorders are more common in patients with Hodgkin lymphoma and may negatively impact overall survival</title><author>Tao, Randa ; Chen, Yuji ; Kim, Seungmin ; Ocier, Krista ; Lloyd, Shane ; Poppe, Matthew M. ; Lee, Catherine J. ; Glenn, Martha J. ; Smith, Ken R. ; Fraser, Alison ; Deshmukh, Vikrant ; Newman, Michael G. ; Snyder, John ; Rowe, Kerry G. ; Gaffney, David K. ; Haaland, Ben ; Hashibe, Mia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3349-99da7df3fb8f7927f35b69dda042668fe27abd7f186398990a36f23bbddd26853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anxiety</topic><topic>Confidence intervals</topic><topic>depression</topic><topic>Diagnosis</topic><topic>Disorders</topic><topic>Health hazards</topic><topic>Health risks</topic><topic>Hematopoietic stem cells</topic><topic>Hodgkin lymphoma</topic><topic>Hodgkin's lymphoma</topic><topic>Lymphoma</topic><topic>Mental disorders</topic><topic>Mental health</topic><topic>Oncology</topic><topic>Patients</topic><topic>Population</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Suicide</topic><topic>Survival</topic><topic>survivorship</topic><topic>Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tao, Randa</creatorcontrib><creatorcontrib>Chen, Yuji</creatorcontrib><creatorcontrib>Kim, Seungmin</creatorcontrib><creatorcontrib>Ocier, Krista</creatorcontrib><creatorcontrib>Lloyd, Shane</creatorcontrib><creatorcontrib>Poppe, Matthew M.</creatorcontrib><creatorcontrib>Lee, Catherine J.</creatorcontrib><creatorcontrib>Glenn, Martha J.</creatorcontrib><creatorcontrib>Smith, Ken R.</creatorcontrib><creatorcontrib>Fraser, Alison</creatorcontrib><creatorcontrib>Deshmukh, Vikrant</creatorcontrib><creatorcontrib>Newman, Michael G.</creatorcontrib><creatorcontrib>Snyder, John</creatorcontrib><creatorcontrib>Rowe, Kerry G.</creatorcontrib><creatorcontrib>Gaffney, David K.</creatorcontrib><creatorcontrib>Haaland, Ben</creatorcontrib><creatorcontrib>Hashibe, Mia</creatorcontrib><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tao, Randa</au><au>Chen, Yuji</au><au>Kim, Seungmin</au><au>Ocier, Krista</au><au>Lloyd, Shane</au><au>Poppe, Matthew M.</au><au>Lee, Catherine J.</au><au>Glenn, Martha J.</au><au>Smith, Ken R.</au><au>Fraser, Alison</au><au>Deshmukh, Vikrant</au><au>Newman, Michael G.</au><au>Snyder, John</au><au>Rowe, Kerry G.</au><au>Gaffney, David K.</au><au>Haaland, Ben</au><au>Hashibe, Mia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mental health disorders are more common in patients with Hodgkin lymphoma and may negatively impact overall survival</atitle><jtitle>Cancer</jtitle><date>2022-10-01</date><risdate>2022</risdate><volume>128</volume><issue>19</issue><spage>3564</spage><epage>3572</epage><pages>3564-3572</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>Background
Long‐term mental health outcomes were characterized in patients who were diagnosed with Hodgkin lymphoma (HL), and risk factors for the development of mental health disorders were identified.
Methods
Patients who were diagnosed with HL between 1997 and 2014 were identified in the Utah Cancer Registry. Each patient was matched with up to five individuals from a general population cohort identified within the Utah Population Database, a unique source of linked records that includes patient and demographic data.
Results
In total, 795 patients who had HL were matched with 3575 individuals from the general population. Compared with the general population, patients who had HL had a higher risk of any mental health diagnosis (hazard ratio, 1.77; 95% confidence interval, 1.57–2.00). Patients with HL had higher risks of anxiety, depression, substance‐related disorders, and suicide and intentional self‐inflicted injuries compared with the general population. The main risk factor associated with an increased risk of being diagnosed with mental health disorders was undergoing hematopoietic stem cell transplantation, with a hazard ratio of 2.06 (95% confidence interval, 1.53–2.76). The diagnosis of any mental health disorder among patients with HL was associated with a detrimental impact on overall survival; the 10‐year overall survival rate was 70% in patients who had a mental health diagnosis compared with 86% in those patients without a mental health diagnosis (p < .0001).
Conclusions
Patients who had HL had an increased risk of various mental health disorders compared with a matched general population. The current data illustrate the importance of attention to mental health in HL survivorship, particularly for patients who undergo therapy with hematopoietic stem cell transplantation.
Hodgkin lymphoma survivors had an increased risk of mental health disorders, and undergoing stem cell transplantation was the only treatment‐related risk factor. Survivors who had a mental health disorder had worse overall survival compared with those who did not develop a mental health disorder.</abstract><cop>Atlanta</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/cncr.34359</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-4235-7652</orcidid><orcidid>https://orcid.org/0000-0001-9379-4732</orcidid><orcidid>https://orcid.org/0000-0003-2587-8955</orcidid><orcidid>https://orcid.org/0000-0002-5752-1611</orcidid></addata></record> |
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| source | Wiley Free Content; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Anxiety Confidence intervals depression Diagnosis Disorders Health hazards Health risks Hematopoietic stem cells Hodgkin lymphoma Hodgkin's lymphoma Lymphoma Mental disorders Mental health Oncology Patients Population Risk analysis Risk factors Stem cell transplantation Stem cells Suicide Survival survivorship Transplantation |
| title | Mental health disorders are more common in patients with Hodgkin lymphoma and may negatively impact overall survival |
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