Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity

The suprachiasmatic nucleus (SCN) is the master circadian clock in mammals and is properly entrained by environmental light cycle. However, the molecular mechanism(s) determining the magnitude of phase shift by light is still not fully understood. The orphan G-protein-coupled receptor Gpr176 is enri...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2022/08/01, Vol.45(8), pp.1172-1179
Hauptverfasser:	Yamaguchi, Yoshiaki, Murai, Iori, Takeda, Momoko, Doi, Shotaro, Seta, Takehito, Hanada, Reiko, Kangawa, Kenji, Okamura, Hitoshi, Miyake, Takahito, Doi, Masao
Format:	Artikel
Sprache:	eng
Schlagworte:	Circadian rhythm Circadian rhythms Entrainment G protein-coupled receptors Gene expression Light light entrainment Locomotor activity Neuromedin neuromedin S neuromedin U orphan receptor Gpr176 Period 1 protein Period 2 protein Phase shift Phenotypes Rodents Suprachiasmatic nucleus
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