Replication Study for the Association of Five SNPs Identified by GWAS and Trastuzumab-Induced Cardiotoxicity in Japanese and Singaporean Cohorts

Trastuzumab (herceptin) is an effective drug for human epidermal growth factor receptor type 2 (HER2)-positive cancer. However, cardiotoxicity remains a serious complication. In our previous genome-wide association study (GWAS), we identified potential associations for five single nucleotide polymor...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2022/08/01, Vol.45(8), pp.1198-1202
Hauptverfasser:	Udagawa, Chihiro, Kuah, Sherwin, Shimoi, Tatsunori, Kato, Ken, Yoshida, Teruhiko, Nakano, Mari Hara, Shimo, Arata, Kojima, Yasuyuki, Yoshie, Reiko, Tsugawa, Koichiro, Mushiroda, Taisei, Tan, Ern Yu, Zembutsu, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiotoxicity Epidermal growth factor ErbB-2 protein Genome-wide association studies Genomes human epidermal growth factor receptor type 2 (HER2) pharmacogenomics Replication Risk assessment single nucleotide polymorphism (SNP) Single-nucleotide polymorphism Statistical analysis Trastuzumab
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