Enantioselective phosphonation of isoquinolines via chiral phosphoric acid-catalyzed dearomatization

Enantioselective phosphonation of isoquinolines via chiral phosphoric acid-catalyzed dearomatization

An efficient and enantioselective phosphonation protocol for construction of chiral α-aminophosphates and α-aminodiarylphosphine oxides has been developed based on chiral phosphoric acid-catalyzed dearomatization of isoquinolines. A series of chiral 1,2-dihydroisoquinolines with dimethoxy phosphoryl...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2022-08, Vol.58 (67), p.9393-9396
Hauptverfasser: Gao, Zhenhua, Guo, Yongbiao
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Enantiomers
Phosphoric acid
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description An efficient and enantioselective phosphonation protocol for construction of chiral α-aminophosphates and α-aminodiarylphosphine oxides has been developed based on chiral phosphoric acid-catalyzed dearomatization of isoquinolines. A series of chiral 1,2-dihydroisoquinolines with dimethoxy phosphoryl or diphenylphosphono substituents at the C1-position were constructed with good to excellent yields and enantioselectivities under mild reaction conditions.
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subjects Enantiomers
Phosphoric acid
title Enantioselective phosphonation of isoquinolines via chiral phosphoric acid-catalyzed dearomatization
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