Microparticle Delivery of a STING Agonist Enables Indirect Activation of NK Cells by Antigen-Presenting Cells

Natural killer (NK) cells are an important member of the innate immune system and can participate in direct tumor cell killing in response to immunotherapies. One class of immunotherapy is stimulator of interferon gene (STING) agonists, which result in a robust type I interferon (IFN-I) response. Mo...

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Veröffentlicht in:	Molecular pharmaceutics 2022-09, Vol.19 (9), p.3125-3138
Hauptverfasser:	Watkins-Schulz, Rebekah, Batty, Cole J., Stiepel, Rebeca T., Schmidt, Megan E., Sandor, Adam M., Chou, Wei-Chun, Ainslie, Kristy M., Bachelder, Eric M., Ting, Jenny P.-Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-Presenting Cells - metabolism Immunotherapy Killer Cells, Natural - metabolism Membrane Proteins - metabolism Mice Mice, Inbred C57BL
Online-Zugang:	Volltext
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