Rhein induces changes in the lysosomal compartment of HeLa cells

Rhein is an anthraquinone found in Rheum palmatum, used in Chinese medicine. Due to potential anticancer properties, the study assessed its effect on the lysosomal compartment, which indirectly influences cell death. The experiment was performed on HeLa cells by treating them with rhein at concentra...

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Veröffentlicht in:	Journal of cellular biochemistry 2022-09, Vol.123 (9), p.1506-1524
Hauptverfasser:	Trybus, Wojciech, Król, Teodora, Trybus, Ewa
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridine orange Anthraquinone Anthraquinones Anticancer properties Apoptosis Autophagy Cancer Caspase-3 Cathepsin D Cell death Cell viability Chloroquine Cytotoxicity DNA damage Evaluation Fluorescence Fluorescence microscopy Herbal medicine lysosomal cell death Lysosomes Membrane permeability Mitochondria Oxidative stress Phagosomes Proteins rhein S phase Toxicity
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