Risk of recurrence and pregnancy outcomes in young women with breast cancer who do and do not undergo fertility preservation
Purpose To assess the impact of fertility preservation (FP) requiring ovarian stimulation on breast cancer outcomes and pregnancy after breast cancer. Methods Women aged ≤ 40 years diagnosed with stage I–III breast cancer between 2007 and 2018 and referred for FP consultation prior to systemic thera...
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| Veröffentlicht in: | Breast cancer research and treatment 2022-09, Vol.195 (2), p.201-208 |
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| creator | Wang, Ying Tesch, Megan E. Lim, Chloe Xu, Ying Hui Lee, Shaina Perdizet, Kirstin Yokom, Dan Warner, Ellen Roberts, Jeffery Lohrisch, Caroline A. |
| description | Purpose
To assess the impact of fertility preservation (FP) requiring ovarian stimulation on breast cancer outcomes and pregnancy after breast cancer.
Methods
Women aged ≤ 40 years diagnosed with stage I–III breast cancer between 2007 and 2018 and referred for FP consultation prior to systemic therapy were identified from a British Columbia fertility center database. The primary endpoint was invasive breast cancer-free survival (iBCFS) and secondary endpoints were overall survival (OS) and achievement of pregnancy. Survival and pregnancy endpoints were compared using Cox and logistic regression analyses, respectively, for patients who did and did not undergo FP.
Results
The study included 153 patients, with 71 (46%) in the FP group and 82 (54%) in the non-FP group. Patients who underwent FP were more likely to be ECOG 0 (99% vs. 88%,
p
= 0.011) and receive chemotherapy (93% vs. 67%,
p
|
| doi_str_mv | 10.1007/s10549-022-06650-z |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2696861922</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A713795014</galeid><sourcerecordid>A713795014</sourcerecordid><originalsourceid>FETCH-LOGICAL-c450t-ab501eb51747c9f33949c36150fc19eee122de76cb3200e7fb7bbda962f0455e3</originalsourceid><addsrcrecordid>eNp9klFrFDEQxxdR8Kx-AZ8CgviydZLsJs1jKVYLBUH0OWSzk73UveRMsh5X_PDmeoVaEcnDkPD7DTPh3zSvKZxSAPk-U-g71QJjLQjRQ3v7pFnRXvJWMiqfNiugQrbiDMTz5kXONwCgJKhV8-uLz99JdCShXVLCYJGYMJJtwimYYPckLsXGDWbiA9nHJUxkV6-B7HxZkyGhyYXYSmIiu3UkY7zzawmxkCWMmKZIHKbiZ1_2h8YZ009TfAwvm2fOzBlf3deT5tvlh68Xn9rrzx-vLs6vW9v1UFoz9EBx6KnspFWOc9UpywXtwVmqEJEyNqIUduAMAKUb5DCMRgnmoOt75CfNu2PfbYo_FsxFb3y2OM8mYFyyZkKJM0EVYxV98xd6E5cU6nSaSaCccWDqgZrMjNoHF0sy9tBUn0vKpaoDd5U6_QdVz4gbb2NA5-v7I-HtH8IazVzWOc7L4a_yY5AdQZtizgmd3ia_MWmvKehDIPQxELoGQt8FQt9WiR-lXOEwYXpY7T_Wb3gmuHs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2701323029</pqid></control><display><type>article</type><title>Risk of recurrence and pregnancy outcomes in young women with breast cancer who do and do not undergo fertility preservation</title><source>SpringerLink Journals - AutoHoldings</source><creator>Wang, Ying ; Tesch, Megan E. ; Lim, Chloe ; Xu, Ying Hui ; Lee, Shaina ; Perdizet, Kirstin ; Yokom, Dan ; Warner, Ellen ; Roberts, Jeffery ; Lohrisch, Caroline A.</creator><creatorcontrib>Wang, Ying ; Tesch, Megan E. ; Lim, Chloe ; Xu, Ying Hui ; Lee, Shaina ; Perdizet, Kirstin ; Yokom, Dan ; Warner, Ellen ; Roberts, Jeffery ; Lohrisch, Caroline A.</creatorcontrib><description>Purpose
To assess the impact of fertility preservation (FP) requiring ovarian stimulation on breast cancer outcomes and pregnancy after breast cancer.
Methods
Women aged ≤ 40 years diagnosed with stage I–III breast cancer between 2007 and 2018 and referred for FP consultation prior to systemic therapy were identified from a British Columbia fertility center database. The primary endpoint was invasive breast cancer-free survival (iBCFS) and secondary endpoints were overall survival (OS) and achievement of pregnancy. Survival and pregnancy endpoints were compared using Cox and logistic regression analyses, respectively, for patients who did and did not undergo FP.
Results
The study included 153 patients, with 71 (46%) in the FP group and 82 (54%) in the non-FP group. Patients who underwent FP were more likely to be ECOG 0 (99% vs. 88%,
p
= 0.011) and receive chemotherapy (93% vs. 67%,
p
< 0.001), but had similar ER positivity status to non-FP patients (70% vs. 79%,
p
= 0.21). Over a median follow-up of 4.1 years, there were no differences in iBCFS (HR 1.006, 95% CI 0.416–2.438,
p
= 0.988) or OS (HR 0.789, 95% CI 0.210–2.956,
p
= 0.725) between FP and non-FP groups. Patients who underwent FP had higher odds of conceiving at least once (OR 3.024, 95% CI 1.312–6.970,
p
= 0.008).
Conclusion
At a median follow-up of 4.1 years, FP did not impact iBCFS or OS, supporting its safety in young women with breast cancer. In addition, patients who underwent FP were more likely to become pregnant after breast cancer, highlighting the value of pre-oncologic treatment FP in survivorship family planning.</description><identifier>ISSN: 0167-6806</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1007/s10549-022-06650-z</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Breast cancer ; Cancer ; Cancer research ; Cancer therapies ; Chemotherapy ; Comparative analysis ; Diseases ; Epidemiology ; Fertility ; Invasiveness ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Oncology ; Ovarian cancer ; Patients ; Pregnancy ; Pregnant women ; Preservation ; Relapse ; Survival ; Womens health ; Young women</subject><ispartof>Breast cancer research and treatment, 2022-09, Vol.195 (2), p.201-208</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-ab501eb51747c9f33949c36150fc19eee122de76cb3200e7fb7bbda962f0455e3</citedby><cites>FETCH-LOGICAL-c450t-ab501eb51747c9f33949c36150fc19eee122de76cb3200e7fb7bbda962f0455e3</cites><orcidid>0000-0003-0478-5987</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10549-022-06650-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10549-022-06650-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Tesch, Megan E.</creatorcontrib><creatorcontrib>Lim, Chloe</creatorcontrib><creatorcontrib>Xu, Ying Hui</creatorcontrib><creatorcontrib>Lee, Shaina</creatorcontrib><creatorcontrib>Perdizet, Kirstin</creatorcontrib><creatorcontrib>Yokom, Dan</creatorcontrib><creatorcontrib>Warner, Ellen</creatorcontrib><creatorcontrib>Roberts, Jeffery</creatorcontrib><creatorcontrib>Lohrisch, Caroline A.</creatorcontrib><title>Risk of recurrence and pregnancy outcomes in young women with breast cancer who do and do not undergo fertility preservation</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><description>Purpose
To assess the impact of fertility preservation (FP) requiring ovarian stimulation on breast cancer outcomes and pregnancy after breast cancer.
Methods
Women aged ≤ 40 years diagnosed with stage I–III breast cancer between 2007 and 2018 and referred for FP consultation prior to systemic therapy were identified from a British Columbia fertility center database. The primary endpoint was invasive breast cancer-free survival (iBCFS) and secondary endpoints were overall survival (OS) and achievement of pregnancy. Survival and pregnancy endpoints were compared using Cox and logistic regression analyses, respectively, for patients who did and did not undergo FP.
Results
The study included 153 patients, with 71 (46%) in the FP group and 82 (54%) in the non-FP group. Patients who underwent FP were more likely to be ECOG 0 (99% vs. 88%,
p
= 0.011) and receive chemotherapy (93% vs. 67%,
p
< 0.001), but had similar ER positivity status to non-FP patients (70% vs. 79%,
p
= 0.21). Over a median follow-up of 4.1 years, there were no differences in iBCFS (HR 1.006, 95% CI 0.416–2.438,
p
= 0.988) or OS (HR 0.789, 95% CI 0.210–2.956,
p
= 0.725) between FP and non-FP groups. Patients who underwent FP had higher odds of conceiving at least once (OR 3.024, 95% CI 1.312–6.970,
p
= 0.008).
Conclusion
At a median follow-up of 4.1 years, FP did not impact iBCFS or OS, supporting its safety in young women with breast cancer. In addition, patients who underwent FP were more likely to become pregnant after breast cancer, highlighting the value of pre-oncologic treatment FP in survivorship family planning.</description><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Comparative analysis</subject><subject>Diseases</subject><subject>Epidemiology</subject><subject>Fertility</subject><subject>Invasiveness</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Oncology</subject><subject>Ovarian cancer</subject><subject>Patients</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Preservation</subject><subject>Relapse</subject><subject>Survival</subject><subject>Womens health</subject><subject>Young women</subject><issn>0167-6806</issn><issn>1573-7217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9klFrFDEQxxdR8Kx-AZ8CgviydZLsJs1jKVYLBUH0OWSzk73UveRMsh5X_PDmeoVaEcnDkPD7DTPh3zSvKZxSAPk-U-g71QJjLQjRQ3v7pFnRXvJWMiqfNiugQrbiDMTz5kXONwCgJKhV8-uLz99JdCShXVLCYJGYMJJtwimYYPckLsXGDWbiA9nHJUxkV6-B7HxZkyGhyYXYSmIiu3UkY7zzawmxkCWMmKZIHKbiZ1_2h8YZ009TfAwvm2fOzBlf3deT5tvlh68Xn9rrzx-vLs6vW9v1UFoz9EBx6KnspFWOc9UpywXtwVmqEJEyNqIUduAMAKUb5DCMRgnmoOt75CfNu2PfbYo_FsxFb3y2OM8mYFyyZkKJM0EVYxV98xd6E5cU6nSaSaCccWDqgZrMjNoHF0sy9tBUn0vKpaoDd5U6_QdVz4gbb2NA5-v7I-HtH8IazVzWOc7L4a_yY5AdQZtizgmd3ia_MWmvKehDIPQxELoGQt8FQt9WiR-lXOEwYXpY7T_Wb3gmuHs</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Wang, Ying</creator><creator>Tesch, Megan E.</creator><creator>Lim, Chloe</creator><creator>Xu, Ying Hui</creator><creator>Lee, Shaina</creator><creator>Perdizet, Kirstin</creator><creator>Yokom, Dan</creator><creator>Warner, Ellen</creator><creator>Roberts, Jeffery</creator><creator>Lohrisch, Caroline A.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0478-5987</orcidid></search><sort><creationdate>20220901</creationdate><title>Risk of recurrence and pregnancy outcomes in young women with breast cancer who do and do not undergo fertility preservation</title><author>Wang, Ying ; Tesch, Megan E. ; Lim, Chloe ; Xu, Ying Hui ; Lee, Shaina ; Perdizet, Kirstin ; Yokom, Dan ; Warner, Ellen ; Roberts, Jeffery ; Lohrisch, Caroline A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-ab501eb51747c9f33949c36150fc19eee122de76cb3200e7fb7bbda962f0455e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cancer research</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Comparative analysis</topic><topic>Diseases</topic><topic>Epidemiology</topic><topic>Fertility</topic><topic>Invasiveness</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Oncology</topic><topic>Ovarian cancer</topic><topic>Patients</topic><topic>Pregnancy</topic><topic>Pregnant women</topic><topic>Preservation</topic><topic>Relapse</topic><topic>Survival</topic><topic>Womens health</topic><topic>Young women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Tesch, Megan E.</creatorcontrib><creatorcontrib>Lim, Chloe</creatorcontrib><creatorcontrib>Xu, Ying Hui</creatorcontrib><creatorcontrib>Lee, Shaina</creatorcontrib><creatorcontrib>Perdizet, Kirstin</creatorcontrib><creatorcontrib>Yokom, Dan</creatorcontrib><creatorcontrib>Warner, Ellen</creatorcontrib><creatorcontrib>Roberts, Jeffery</creatorcontrib><creatorcontrib>Lohrisch, Caroline A.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Breast cancer research and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Ying</au><au>Tesch, Megan E.</au><au>Lim, Chloe</au><au>Xu, Ying Hui</au><au>Lee, Shaina</au><au>Perdizet, Kirstin</au><au>Yokom, Dan</au><au>Warner, Ellen</au><au>Roberts, Jeffery</au><au>Lohrisch, Caroline A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of recurrence and pregnancy outcomes in young women with breast cancer who do and do not undergo fertility preservation</atitle><jtitle>Breast cancer research and treatment</jtitle><stitle>Breast Cancer Res Treat</stitle><date>2022-09-01</date><risdate>2022</risdate><volume>195</volume><issue>2</issue><spage>201</spage><epage>208</epage><pages>201-208</pages><issn>0167-6806</issn><eissn>1573-7217</eissn><abstract>Purpose
To assess the impact of fertility preservation (FP) requiring ovarian stimulation on breast cancer outcomes and pregnancy after breast cancer.
Methods
Women aged ≤ 40 years diagnosed with stage I–III breast cancer between 2007 and 2018 and referred for FP consultation prior to systemic therapy were identified from a British Columbia fertility center database. The primary endpoint was invasive breast cancer-free survival (iBCFS) and secondary endpoints were overall survival (OS) and achievement of pregnancy. Survival and pregnancy endpoints were compared using Cox and logistic regression analyses, respectively, for patients who did and did not undergo FP.
Results
The study included 153 patients, with 71 (46%) in the FP group and 82 (54%) in the non-FP group. Patients who underwent FP were more likely to be ECOG 0 (99% vs. 88%,
p
= 0.011) and receive chemotherapy (93% vs. 67%,
p
< 0.001), but had similar ER positivity status to non-FP patients (70% vs. 79%,
p
= 0.21). Over a median follow-up of 4.1 years, there were no differences in iBCFS (HR 1.006, 95% CI 0.416–2.438,
p
= 0.988) or OS (HR 0.789, 95% CI 0.210–2.956,
p
= 0.725) between FP and non-FP groups. Patients who underwent FP had higher odds of conceiving at least once (OR 3.024, 95% CI 1.312–6.970,
p
= 0.008).
Conclusion
At a median follow-up of 4.1 years, FP did not impact iBCFS or OS, supporting its safety in young women with breast cancer. In addition, patients who underwent FP were more likely to become pregnant after breast cancer, highlighting the value of pre-oncologic treatment FP in survivorship family planning.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10549-022-06650-z</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0478-5987</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Breast cancer research and treatment, 2022-09, Vol.195 (2), p.201-208 |
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| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Breast cancer Cancer Cancer research Cancer therapies Chemotherapy Comparative analysis Diseases Epidemiology Fertility Invasiveness Medical research Medicine Medicine & Public Health Medicine, Experimental Oncology Ovarian cancer Patients Pregnancy Pregnant women Preservation Relapse Survival Womens health Young women |
| title | Risk of recurrence and pregnancy outcomes in young women with breast cancer who do and do not undergo fertility preservation |
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