A dose regimen-finding study to evaluate the safety, tolerability, pharmacokinetics, and activity of oratecan in subjects with advanced malignancies

Purpose Irinotecan is a commonly used chemotherapeutic in solid tumor malignancies. Oratecan is an investigational product comprised of encequidar methanesulfonate, a novel minimally absorbed P-glycoprotein pump inhibitor, and irinotecan. This study sought to determine the maximum tolerated dose (MT...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2022-08, Vol.90 (2), p.175-187
Hauptverfasser:	Boland, Patrick M., Fountzilas, Christos, Fakih, Marwan, Opyrchal, Mateusz, Diamond, Jennifer R., Corr, Bradley, Ma, Wen Wee, Redman, Michelle, Chan, Wing-Kai, Wang, Hui, Kramer, Doug, Kwan, Rudolf, Cutler, David, Zhi, Jay, Jimeno, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antitumor activity Cancer Cancer Research Chemotherapy Dosage Exposure Glycoproteins Intravenous administration Irinotecan Liver Medicine Medicine & Public Health Metabolites Metastasis Neutropenia Oncology Oral administration Original Article P-Glycoprotein Pharmacokinetics Pharmacology Pharmacology/Toxicology Solid tumors Toxicity Tumors
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