Effect of feeding with standard or higher-density formulas on anthropometric measures in children with congenital heart defects after corrective surgery: a randomized clinical trial
Objectives The aim of the present study was to assess the efficacy of feeding a higher-density formula (HDF) in infant with congenital heart disease (CHD). Methods In a parallel randomized trial, infants (6 to 12 months) who underwent CHD corrective surgery received either a standard-density formula...
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| Veröffentlicht in: | European journal of clinical nutrition 2022-12, Vol.76 (12), p.1713-1718 |
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| creator | Aryafar, Maryam Mahdavi, Mohammad Shahzadi, Hossein Nasrollahzadeh, Javad |
| description | Objectives
The aim of the present study was to assess the efficacy of feeding a higher-density formula (HDF) in infant with congenital heart disease (CHD).
Methods
In a parallel randomized trial, infants (6 to 12 months) who underwent CHD corrective surgery received either a standard-density formula (SDF, 67 kcal /100 ml) or an HDF (90 kcal/100 ml) after discharge from the intensive care unit for 8 weeks. In addition to the formula, infants could receive breast milk or complementary food. Anthropometry, biochemistry, and formula intake were collected.
Result
Sixty-four infants completed the study (
n
= 32 in each group). All infants gained weight. The mean ± standard deviation (SD) of weight z score at baseline and week-8 were −2.38 ± 10.04 to −1.38 + 0.97 in the SDF group and −2.69 ± 1.19 to −0.89 ± 0.90 in the HDF group (between-group
p
= 0.0001). Both groups gained length, but showed a decline in length z-score which was significant in the SDF group but not significant in the HDF group. Mid-upper arm circumference and its z score improved in both groups, with more improvement in the HDF group. Serum albumin level was higher in the HDF than the SDF group at week-8, but no significant between-group differences were observed in hemoglobin, serum ferritin, or iron. Symptoms of gastrointestinal intolerance were not reported, but parents of 4 infants in the HDF group complained of their infants’ constipation.
Conclusion
Feeding infants using a concentrated formula could increase infants’ weight gain and growth, and improve the nutritional status after CHD surgery. |
| doi_str_mv | 10.1038/s41430-022-01186-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2696859574</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2696859574</sourcerecordid><originalsourceid>FETCH-LOGICAL-c305t-6f7ab5cf66f1899ea0991ffb48d86cae4288d3d575c43b7d7bd8fce4b5622cba3</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhSMEopfCC7BAltiwCdjxX8IOVaUgVWID68ixxzeuEvsydkCX9-L9cHsLSCxYWdZ855zRnKZ5zuhrRnn_JgsmOG1p17WUsV61_EGzY0KrVipBHzY7OkjRckr1WfMk5xtK61B3j5szLgeqOGe75uel92ALSZ54ABfinnwPZSa5mOgMOpKQzGE_A7YOYg7lSHzCdVtMJikSE8uM6ZBWKBgsWcHkDSGTEImdw-IQ4snPpriHGIpZyAwGC3Fwm5uJ8QWwjhHrN3wDUg32gMe3xBCsO6Q1_ABH7BJisFVdc8zytHnkzZLh2f173nx5f_n54kN7_enq48W769ZyKkurvDaTtF4pz_phAEOHgXk_id71yhoQXd877qSWVvBJOz253lsQk1RdZyfDz5tXJ98Dpq8b5DKuIVtYFhMhbXns1KB6OUgtKvryH_QmbRjrdmOnBWNSat1XqjtRFlPOCH48YFgNHkdGx9tSx1OpYy11vCt15FX04t56m1ZwfyS_W6wAPwG5juqd8W_2f2x_AZKQsg0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2741155778</pqid></control><display><type>article</type><title>Effect of feeding with standard or higher-density formulas on anthropometric measures in children with congenital heart defects after corrective surgery: a randomized clinical trial</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Aryafar, Maryam ; Mahdavi, Mohammad ; Shahzadi, Hossein ; Nasrollahzadeh, Javad</creator><creatorcontrib>Aryafar, Maryam ; Mahdavi, Mohammad ; Shahzadi, Hossein ; Nasrollahzadeh, Javad</creatorcontrib><description>Objectives
The aim of the present study was to assess the efficacy of feeding a higher-density formula (HDF) in infant with congenital heart disease (CHD).
Methods
In a parallel randomized trial, infants (6 to 12 months) who underwent CHD corrective surgery received either a standard-density formula (SDF, 67 kcal /100 ml) or an HDF (90 kcal/100 ml) after discharge from the intensive care unit for 8 weeks. In addition to the formula, infants could receive breast milk or complementary food. Anthropometry, biochemistry, and formula intake were collected.
Result
Sixty-four infants completed the study (
n
= 32 in each group). All infants gained weight. The mean ± standard deviation (SD) of weight z score at baseline and week-8 were −2.38 ± 10.04 to −1.38 + 0.97 in the SDF group and −2.69 ± 1.19 to −0.89 ± 0.90 in the HDF group (between-group
p
= 0.0001). Both groups gained length, but showed a decline in length z-score which was significant in the SDF group but not significant in the HDF group. Mid-upper arm circumference and its z score improved in both groups, with more improvement in the HDF group. Serum albumin level was higher in the HDF than the SDF group at week-8, but no significant between-group differences were observed in hemoglobin, serum ferritin, or iron. Symptoms of gastrointestinal intolerance were not reported, but parents of 4 infants in the HDF group complained of their infants’ constipation.
Conclusion
Feeding infants using a concentrated formula could increase infants’ weight gain and growth, and improve the nutritional status after CHD surgery.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/s41430-022-01186-3</identifier><identifier>PMID: 35906331</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/75 ; 692/700/2814 ; Anthropometry ; Arm circumference ; Body measurements ; Body weight gain ; Breast Feeding ; Breast milk ; Cardiovascular diseases ; Child ; Clinical Nutrition ; Constipation ; Density ; Epidemiology ; Female ; Ferritin ; Heart Defects, Congenital - surgery ; Heart diseases ; Hemoglobin ; Humans ; Infant ; Infant Formula ; Infant Nutritional Physiological Phenomena ; Infants ; Internal Medicine ; Intolerance ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Milk, Human ; Nutritional Status ; Public Health ; Serum albumin ; Signs and symptoms ; Surgery ; Weight Gain</subject><ispartof>European journal of clinical nutrition, 2022-12, Vol.76 (12), p.1713-1718</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Nature Limited.</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-6f7ab5cf66f1899ea0991ffb48d86cae4288d3d575c43b7d7bd8fce4b5622cba3</citedby><cites>FETCH-LOGICAL-c305t-6f7ab5cf66f1899ea0991ffb48d86cae4288d3d575c43b7d7bd8fce4b5622cba3</cites><orcidid>0000-0002-9133-1870</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35906331$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aryafar, Maryam</creatorcontrib><creatorcontrib>Mahdavi, Mohammad</creatorcontrib><creatorcontrib>Shahzadi, Hossein</creatorcontrib><creatorcontrib>Nasrollahzadeh, Javad</creatorcontrib><title>Effect of feeding with standard or higher-density formulas on anthropometric measures in children with congenital heart defects after corrective surgery: a randomized clinical trial</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Objectives
The aim of the present study was to assess the efficacy of feeding a higher-density formula (HDF) in infant with congenital heart disease (CHD).
Methods
In a parallel randomized trial, infants (6 to 12 months) who underwent CHD corrective surgery received either a standard-density formula (SDF, 67 kcal /100 ml) or an HDF (90 kcal/100 ml) after discharge from the intensive care unit for 8 weeks. In addition to the formula, infants could receive breast milk or complementary food. Anthropometry, biochemistry, and formula intake were collected.
Result
Sixty-four infants completed the study (
n
= 32 in each group). All infants gained weight. The mean ± standard deviation (SD) of weight z score at baseline and week-8 were −2.38 ± 10.04 to −1.38 + 0.97 in the SDF group and −2.69 ± 1.19 to −0.89 ± 0.90 in the HDF group (between-group
p
= 0.0001). Both groups gained length, but showed a decline in length z-score which was significant in the SDF group but not significant in the HDF group. Mid-upper arm circumference and its z score improved in both groups, with more improvement in the HDF group. Serum albumin level was higher in the HDF than the SDF group at week-8, but no significant between-group differences were observed in hemoglobin, serum ferritin, or iron. Symptoms of gastrointestinal intolerance were not reported, but parents of 4 infants in the HDF group complained of their infants’ constipation.
Conclusion
Feeding infants using a concentrated formula could increase infants’ weight gain and growth, and improve the nutritional status after CHD surgery.</description><subject>692/699/75</subject><subject>692/700/2814</subject><subject>Anthropometry</subject><subject>Arm circumference</subject><subject>Body measurements</subject><subject>Body weight gain</subject><subject>Breast Feeding</subject><subject>Breast milk</subject><subject>Cardiovascular diseases</subject><subject>Child</subject><subject>Clinical Nutrition</subject><subject>Constipation</subject><subject>Density</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Ferritin</subject><subject>Heart Defects, Congenital - surgery</subject><subject>Heart diseases</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant Formula</subject><subject>Infant Nutritional Physiological Phenomena</subject><subject>Infants</subject><subject>Internal Medicine</subject><subject>Intolerance</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Milk, Human</subject><subject>Nutritional Status</subject><subject>Public Health</subject><subject>Serum albumin</subject><subject>Signs and symptoms</subject><subject>Surgery</subject><subject>Weight Gain</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kc1u1TAQhSMEopfCC7BAltiwCdjxX8IOVaUgVWID68ixxzeuEvsydkCX9-L9cHsLSCxYWdZ855zRnKZ5zuhrRnn_JgsmOG1p17WUsV61_EGzY0KrVipBHzY7OkjRckr1WfMk5xtK61B3j5szLgeqOGe75uel92ALSZ54ABfinnwPZSa5mOgMOpKQzGE_A7YOYg7lSHzCdVtMJikSE8uM6ZBWKBgsWcHkDSGTEImdw-IQ4snPpriHGIpZyAwGC3Fwm5uJ8QWwjhHrN3wDUg32gMe3xBCsO6Q1_ABH7BJisFVdc8zytHnkzZLh2f173nx5f_n54kN7_enq48W769ZyKkurvDaTtF4pz_phAEOHgXk_id71yhoQXd877qSWVvBJOz253lsQk1RdZyfDz5tXJ98Dpq8b5DKuIVtYFhMhbXns1KB6OUgtKvryH_QmbRjrdmOnBWNSat1XqjtRFlPOCH48YFgNHkdGx9tSx1OpYy11vCt15FX04t56m1ZwfyS_W6wAPwG5juqd8W_2f2x_AZKQsg0</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Aryafar, Maryam</creator><creator>Mahdavi, Mohammad</creator><creator>Shahzadi, Hossein</creator><creator>Nasrollahzadeh, Javad</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9133-1870</orcidid></search><sort><creationdate>20221201</creationdate><title>Effect of feeding with standard or higher-density formulas on anthropometric measures in children with congenital heart defects after corrective surgery: a randomized clinical trial</title><author>Aryafar, Maryam ; Mahdavi, Mohammad ; Shahzadi, Hossein ; Nasrollahzadeh, Javad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-6f7ab5cf66f1899ea0991ffb48d86cae4288d3d575c43b7d7bd8fce4b5622cba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>692/699/75</topic><topic>692/700/2814</topic><topic>Anthropometry</topic><topic>Arm circumference</topic><topic>Body measurements</topic><topic>Body weight gain</topic><topic>Breast Feeding</topic><topic>Breast milk</topic><topic>Cardiovascular diseases</topic><topic>Child</topic><topic>Clinical Nutrition</topic><topic>Constipation</topic><topic>Density</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Ferritin</topic><topic>Heart Defects, Congenital - surgery</topic><topic>Heart diseases</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant Formula</topic><topic>Infant Nutritional Physiological Phenomena</topic><topic>Infants</topic><topic>Internal Medicine</topic><topic>Intolerance</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Milk, Human</topic><topic>Nutritional Status</topic><topic>Public Health</topic><topic>Serum albumin</topic><topic>Signs and symptoms</topic><topic>Surgery</topic><topic>Weight Gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aryafar, Maryam</creatorcontrib><creatorcontrib>Mahdavi, Mohammad</creatorcontrib><creatorcontrib>Shahzadi, Hossein</creatorcontrib><creatorcontrib>Nasrollahzadeh, Javad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aryafar, Maryam</au><au>Mahdavi, Mohammad</au><au>Shahzadi, Hossein</au><au>Nasrollahzadeh, Javad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of feeding with standard or higher-density formulas on anthropometric measures in children with congenital heart defects after corrective surgery: a randomized clinical trial</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>76</volume><issue>12</issue><spage>1713</spage><epage>1718</epage><pages>1713-1718</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Objectives
The aim of the present study was to assess the efficacy of feeding a higher-density formula (HDF) in infant with congenital heart disease (CHD).
Methods
In a parallel randomized trial, infants (6 to 12 months) who underwent CHD corrective surgery received either a standard-density formula (SDF, 67 kcal /100 ml) or an HDF (90 kcal/100 ml) after discharge from the intensive care unit for 8 weeks. In addition to the formula, infants could receive breast milk or complementary food. Anthropometry, biochemistry, and formula intake were collected.
Result
Sixty-four infants completed the study (
n
= 32 in each group). All infants gained weight. The mean ± standard deviation (SD) of weight z score at baseline and week-8 were −2.38 ± 10.04 to −1.38 + 0.97 in the SDF group and −2.69 ± 1.19 to −0.89 ± 0.90 in the HDF group (between-group
p
= 0.0001). Both groups gained length, but showed a decline in length z-score which was significant in the SDF group but not significant in the HDF group. Mid-upper arm circumference and its z score improved in both groups, with more improvement in the HDF group. Serum albumin level was higher in the HDF than the SDF group at week-8, but no significant between-group differences were observed in hemoglobin, serum ferritin, or iron. Symptoms of gastrointestinal intolerance were not reported, but parents of 4 infants in the HDF group complained of their infants’ constipation.
Conclusion
Feeding infants using a concentrated formula could increase infants’ weight gain and growth, and improve the nutritional status after CHD surgery.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>35906331</pmid><doi>10.1038/s41430-022-01186-3</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-9133-1870</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-3007 |
| ispartof | European journal of clinical nutrition, 2022-12, Vol.76 (12), p.1713-1718 |
| issn | 0954-3007 1476-5640 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | 692/699/75 692/700/2814 Anthropometry Arm circumference Body measurements Body weight gain Breast Feeding Breast milk Cardiovascular diseases Child Clinical Nutrition Constipation Density Epidemiology Female Ferritin Heart Defects, Congenital - surgery Heart diseases Hemoglobin Humans Infant Infant Formula Infant Nutritional Physiological Phenomena Infants Internal Medicine Intolerance Medicine Medicine & Public Health Metabolic Diseases Milk, Human Nutritional Status Public Health Serum albumin Signs and symptoms Surgery Weight Gain |
| title | Effect of feeding with standard or higher-density formulas on anthropometric measures in children with congenital heart defects after corrective surgery: a randomized clinical trial |
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