Gestational weight gain and visceral adiposity in adult offspring: Is there a link with the fecal abundance of Acidaminococcus genus?
Intrauterine environment can influence the offspring’s body adiposity whose distribution affect the cardiometabolic risk. Underlying mechanisms may involve the gut microbiome. We investigated associations of gestational weight gain with the adult offspring’s gut microbiota, body adiposity and relate...
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| Veröffentlicht in: | European journal of clinical nutrition 2022-12, Vol.76 (12), p.1705-1712 |
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| creator | Freitas, R G B O N Vasques, A C J Fernandes, G R Ribeiro, F B Solar, I Barbosa, M G Almeida-Pititto, B Geloneze, B Ferreira, S R G |
| description | Intrauterine environment can influence the offspring’s body adiposity whose distribution affect the cardiometabolic risk. Underlying mechanisms may involve the gut microbiome. We investigated associations of gestational weight gain with the adult offspring’s gut microbiota, body adiposity and related parameters in participants of the Nutritionists’ Health Study.
Methods
This cross-sectional analysis included 114 women who had early life and clinical data, body composition, and biological samples collected. The structure of fecal microbiota was analyzed targeting the V4 region of the 16 S rRNA gene. Beta diversity was calculated by PCoA and PERMANOVA used to test the impact of categorical variables into the diversity. Bacterial clusters were identified based on the Jensen-Shannon divergence matrix and Calinski–Harabasz index. Correlations were tested by Spearman coefficient.
Results
Median age was 28 (IQR 24–31) years and BMI 24.5 (IQR 21.4–28.0) kg/m
2
. Fifty-eight participants were assigned to a profile driven by Prevotella and 56 to another driven by Blautia. Visceral adipose tissue was correlated to abundance of
Acidaminococcus
genus considering the entire sample (
r
= 0.37;
p
|
| doi_str_mv | 10.1038/s41430-022-01182-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2696859551</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2696859551</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-be52e4382dc66746668a7ea323576e4debaa23051a7eb18486fcd96637036a683</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhS1ERaeFF2CBLLFhE_C_EzaoqqBUqtRNu7Yc-2bGJWMPdkLVB-C9cZoCEgtWlu79zrHuOQi9puQ9Jbz9UAQVnDSEsYZQ2rJGP0MbKrRqpBLkOdqQToqGE6KP0Ukpd4TUpWYv0DGXHVGc8w36eQFlslNI0Y74HsJ2N-GtDRHb6PGPUBzkurA-HFIJ0wNeNn4eJ5yGoRxyiNuP-LLgaQcZsMVjiN_wfZh2ywQP4BZxP0dvo4OqwWcueLsPMbnk3FzwFuJcPr1ER4MdC7x6ek_R7ZfPN-dfm6vri8vzs6vGcS2npgfJQPCWeaeUFkqp1mqwnHGpFQgPvbWME0nrtKetaNXgfKcU14Qrq1p-it6tvoecvs_1crNfThxHGyHNxTDVqVZ2UtKKvv0HvUtzrilVSgtKpey4qhRbKZdTKRkGUzPZ2_xgKDFLSWYtydSSzGNJRlfRmyfrud-D_yP53UoF-AqsCUP--_d_bH8BME2c8g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2741155936</pqid></control><display><type>article</type><title>Gestational weight gain and visceral adiposity in adult offspring: Is there a link with the fecal abundance of Acidaminococcus genus?</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Freitas, R G B O N ; Vasques, A C J ; Fernandes, G R ; Ribeiro, F B ; Solar, I ; Barbosa, M G ; Almeida-Pititto, B ; Geloneze, B ; Ferreira, S R G</creator><creatorcontrib>Freitas, R G B O N ; Vasques, A C J ; Fernandes, G R ; Ribeiro, F B ; Solar, I ; Barbosa, M G ; Almeida-Pititto, B ; Geloneze, B ; Ferreira, S R G</creatorcontrib><description>Intrauterine environment can influence the offspring’s body adiposity whose distribution affect the cardiometabolic risk. Underlying mechanisms may involve the gut microbiome. We investigated associations of gestational weight gain with the adult offspring’s gut microbiota, body adiposity and related parameters in participants of the Nutritionists’ Health Study.
Methods
This cross-sectional analysis included 114 women who had early life and clinical data, body composition, and biological samples collected. The structure of fecal microbiota was analyzed targeting the V4 region of the 16 S rRNA gene. Beta diversity was calculated by PCoA and PERMANOVA used to test the impact of categorical variables into the diversity. Bacterial clusters were identified based on the Jensen-Shannon divergence matrix and Calinski–Harabasz index. Correlations were tested by Spearman coefficient.
Results
Median age was 28 (IQR 24–31) years and BMI 24.5 (IQR 21.4–28.0) kg/m
2
. Fifty-eight participants were assigned to a profile driven by Prevotella and 56 to another driven by Blautia. Visceral adipose tissue was correlated to abundance of
Acidaminococcus
genus considering the entire sample (
r
= 0.37;
p
< 0.001) and the profiles (Blautia:
r
= 0.35,
p
= 0.009, and Prevotella:
r
= 0.38,
p
= 0.006). In Blautia-driven profile, the same genus was also correlated to maternal gestational weight gain (
r
= 0.38,
p
= 0.006).
Conclusions
Association of
Acidaminococcus
with gestational weight gain could reinforce the relevance with mothers’ nutritional status for gut colonization at the beginning of life. Whether
Acidaminococcus
abundance could be a marker for central distribution of adiposity in young women requires further investigation.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/s41430-022-01182-7</identifier><identifier>PMID: 35906333</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>38/23 ; 692/163/2743 ; 692/163/2743/393 ; Abundance ; Acidaminococcus ; Adipose tissue ; Adiposity ; Adult ; Adult Children ; Biological properties ; Biological samples ; Blautia ; Body composition ; Body Mass Index ; Body weight gain ; Clinical Nutrition ; Correlation ; Cross-Sectional Studies ; Epidemiology ; Fecal microflora ; Female ; Genetic crosses ; Gestational Weight Gain ; Health risks ; Humans ; Internal Medicine ; Intestinal microflora ; Intrauterine exposure ; Mathematical analysis ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Microbiomes ; Microbiota ; Nutritional status ; Obesity ; Obesity, Abdominal ; Offspring ; Prevotella ; Public Health ; rRNA</subject><ispartof>European journal of clinical nutrition, 2022-12, Vol.76 (12), p.1705-1712</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer Nature Limited.</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-be52e4382dc66746668a7ea323576e4debaa23051a7eb18486fcd96637036a683</citedby><cites>FETCH-LOGICAL-c375t-be52e4382dc66746668a7ea323576e4debaa23051a7eb18486fcd96637036a683</cites><orcidid>0000-0002-0557-4578 ; 0000-0002-7015-7391</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41430-022-01182-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41430-022-01182-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35906333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Freitas, R G B O N</creatorcontrib><creatorcontrib>Vasques, A C J</creatorcontrib><creatorcontrib>Fernandes, G R</creatorcontrib><creatorcontrib>Ribeiro, F B</creatorcontrib><creatorcontrib>Solar, I</creatorcontrib><creatorcontrib>Barbosa, M G</creatorcontrib><creatorcontrib>Almeida-Pititto, B</creatorcontrib><creatorcontrib>Geloneze, B</creatorcontrib><creatorcontrib>Ferreira, S R G</creatorcontrib><title>Gestational weight gain and visceral adiposity in adult offspring: Is there a link with the fecal abundance of Acidaminococcus genus?</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Intrauterine environment can influence the offspring’s body adiposity whose distribution affect the cardiometabolic risk. Underlying mechanisms may involve the gut microbiome. We investigated associations of gestational weight gain with the adult offspring’s gut microbiota, body adiposity and related parameters in participants of the Nutritionists’ Health Study.
Methods
This cross-sectional analysis included 114 women who had early life and clinical data, body composition, and biological samples collected. The structure of fecal microbiota was analyzed targeting the V4 region of the 16 S rRNA gene. Beta diversity was calculated by PCoA and PERMANOVA used to test the impact of categorical variables into the diversity. Bacterial clusters were identified based on the Jensen-Shannon divergence matrix and Calinski–Harabasz index. Correlations were tested by Spearman coefficient.
Results
Median age was 28 (IQR 24–31) years and BMI 24.5 (IQR 21.4–28.0) kg/m
2
. Fifty-eight participants were assigned to a profile driven by Prevotella and 56 to another driven by Blautia. Visceral adipose tissue was correlated to abundance of
Acidaminococcus
genus considering the entire sample (
r
= 0.37;
p
< 0.001) and the profiles (Blautia:
r
= 0.35,
p
= 0.009, and Prevotella:
r
= 0.38,
p
= 0.006). In Blautia-driven profile, the same genus was also correlated to maternal gestational weight gain (
r
= 0.38,
p
= 0.006).
Conclusions
Association of
Acidaminococcus
with gestational weight gain could reinforce the relevance with mothers’ nutritional status for gut colonization at the beginning of life. Whether
Acidaminococcus
abundance could be a marker for central distribution of adiposity in young women requires further investigation.</description><subject>38/23</subject><subject>692/163/2743</subject><subject>692/163/2743/393</subject><subject>Abundance</subject><subject>Acidaminococcus</subject><subject>Adipose tissue</subject><subject>Adiposity</subject><subject>Adult</subject><subject>Adult Children</subject><subject>Biological properties</subject><subject>Biological samples</subject><subject>Blautia</subject><subject>Body composition</subject><subject>Body Mass Index</subject><subject>Body weight gain</subject><subject>Clinical Nutrition</subject><subject>Correlation</subject><subject>Cross-Sectional Studies</subject><subject>Epidemiology</subject><subject>Fecal microflora</subject><subject>Female</subject><subject>Genetic crosses</subject><subject>Gestational Weight Gain</subject><subject>Health risks</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Intestinal microflora</subject><subject>Intrauterine exposure</subject><subject>Mathematical analysis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Nutritional status</subject><subject>Obesity</subject><subject>Obesity, Abdominal</subject><subject>Offspring</subject><subject>Prevotella</subject><subject>Public Health</subject><subject>rRNA</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kc1u1DAUhS1ERaeFF2CBLLFhE_C_EzaoqqBUqtRNu7Yc-2bGJWMPdkLVB-C9cZoCEgtWlu79zrHuOQi9puQ9Jbz9UAQVnDSEsYZQ2rJGP0MbKrRqpBLkOdqQToqGE6KP0Ukpd4TUpWYv0DGXHVGc8w36eQFlslNI0Y74HsJ2N-GtDRHb6PGPUBzkurA-HFIJ0wNeNn4eJ5yGoRxyiNuP-LLgaQcZsMVjiN_wfZh2ywQP4BZxP0dvo4OqwWcueLsPMbnk3FzwFuJcPr1ER4MdC7x6ek_R7ZfPN-dfm6vri8vzs6vGcS2npgfJQPCWeaeUFkqp1mqwnHGpFQgPvbWME0nrtKetaNXgfKcU14Qrq1p-it6tvoecvs_1crNfThxHGyHNxTDVqVZ2UtKKvv0HvUtzrilVSgtKpey4qhRbKZdTKRkGUzPZ2_xgKDFLSWYtydSSzGNJRlfRmyfrud-D_yP53UoF-AqsCUP--_d_bH8BME2c8g</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Freitas, R G B O N</creator><creator>Vasques, A C J</creator><creator>Fernandes, G R</creator><creator>Ribeiro, F B</creator><creator>Solar, I</creator><creator>Barbosa, M G</creator><creator>Almeida-Pititto, B</creator><creator>Geloneze, B</creator><creator>Ferreira, S R G</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0557-4578</orcidid><orcidid>https://orcid.org/0000-0002-7015-7391</orcidid></search><sort><creationdate>20221201</creationdate><title>Gestational weight gain and visceral adiposity in adult offspring: Is there a link with the fecal abundance of Acidaminococcus genus?</title><author>Freitas, R G B O N ; Vasques, A C J ; Fernandes, G R ; Ribeiro, F B ; Solar, I ; Barbosa, M G ; Almeida-Pititto, B ; Geloneze, B ; Ferreira, S R G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-be52e4382dc66746668a7ea323576e4debaa23051a7eb18486fcd96637036a683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>38/23</topic><topic>692/163/2743</topic><topic>692/163/2743/393</topic><topic>Abundance</topic><topic>Acidaminococcus</topic><topic>Adipose tissue</topic><topic>Adiposity</topic><topic>Adult</topic><topic>Adult Children</topic><topic>Biological properties</topic><topic>Biological samples</topic><topic>Blautia</topic><topic>Body composition</topic><topic>Body Mass Index</topic><topic>Body weight gain</topic><topic>Clinical Nutrition</topic><topic>Correlation</topic><topic>Cross-Sectional Studies</topic><topic>Epidemiology</topic><topic>Fecal microflora</topic><topic>Female</topic><topic>Genetic crosses</topic><topic>Gestational Weight Gain</topic><topic>Health risks</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Intestinal microflora</topic><topic>Intrauterine exposure</topic><topic>Mathematical analysis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>Nutritional status</topic><topic>Obesity</topic><topic>Obesity, Abdominal</topic><topic>Offspring</topic><topic>Prevotella</topic><topic>Public Health</topic><topic>rRNA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Freitas, R G B O N</creatorcontrib><creatorcontrib>Vasques, A C J</creatorcontrib><creatorcontrib>Fernandes, G R</creatorcontrib><creatorcontrib>Ribeiro, F B</creatorcontrib><creatorcontrib>Solar, I</creatorcontrib><creatorcontrib>Barbosa, M G</creatorcontrib><creatorcontrib>Almeida-Pititto, B</creatorcontrib><creatorcontrib>Geloneze, B</creatorcontrib><creatorcontrib>Ferreira, S R G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public 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Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Freitas, R G B O N</au><au>Vasques, A C J</au><au>Fernandes, G R</au><au>Ribeiro, F B</au><au>Solar, I</au><au>Barbosa, M G</au><au>Almeida-Pititto, B</au><au>Geloneze, B</au><au>Ferreira, S R G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gestational weight gain and visceral adiposity in adult offspring: Is there a link with the fecal abundance of Acidaminococcus genus?</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>76</volume><issue>12</issue><spage>1705</spage><epage>1712</epage><pages>1705-1712</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Intrauterine environment can influence the offspring’s body adiposity whose distribution affect the cardiometabolic risk. Underlying mechanisms may involve the gut microbiome. We investigated associations of gestational weight gain with the adult offspring’s gut microbiota, body adiposity and related parameters in participants of the Nutritionists’ Health Study.
Methods
This cross-sectional analysis included 114 women who had early life and clinical data, body composition, and biological samples collected. The structure of fecal microbiota was analyzed targeting the V4 region of the 16 S rRNA gene. Beta diversity was calculated by PCoA and PERMANOVA used to test the impact of categorical variables into the diversity. Bacterial clusters were identified based on the Jensen-Shannon divergence matrix and Calinski–Harabasz index. Correlations were tested by Spearman coefficient.
Results
Median age was 28 (IQR 24–31) years and BMI 24.5 (IQR 21.4–28.0) kg/m
2
. Fifty-eight participants were assigned to a profile driven by Prevotella and 56 to another driven by Blautia. Visceral adipose tissue was correlated to abundance of
Acidaminococcus
genus considering the entire sample (
r
= 0.37;
p
< 0.001) and the profiles (Blautia:
r
= 0.35,
p
= 0.009, and Prevotella:
r
= 0.38,
p
= 0.006). In Blautia-driven profile, the same genus was also correlated to maternal gestational weight gain (
r
= 0.38,
p
= 0.006).
Conclusions
Association of
Acidaminococcus
with gestational weight gain could reinforce the relevance with mothers’ nutritional status for gut colonization at the beginning of life. Whether
Acidaminococcus
abundance could be a marker for central distribution of adiposity in young women requires further investigation.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>35906333</pmid><doi>10.1038/s41430-022-01182-7</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0557-4578</orcidid><orcidid>https://orcid.org/0000-0002-7015-7391</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-3007 |
| ispartof | European journal of clinical nutrition, 2022-12, Vol.76 (12), p.1705-1712 |
| issn | 0954-3007 1476-5640 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2696859551 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | 38/23 692/163/2743 692/163/2743/393 Abundance Acidaminococcus Adipose tissue Adiposity Adult Adult Children Biological properties Biological samples Blautia Body composition Body Mass Index Body weight gain Clinical Nutrition Correlation Cross-Sectional Studies Epidemiology Fecal microflora Female Genetic crosses Gestational Weight Gain Health risks Humans Internal Medicine Intestinal microflora Intrauterine exposure Mathematical analysis Medicine Medicine & Public Health Metabolic Diseases Microbiomes Microbiota Nutritional status Obesity Obesity, Abdominal Offspring Prevotella Public Health rRNA |
| title | Gestational weight gain and visceral adiposity in adult offspring: Is there a link with the fecal abundance of Acidaminococcus genus? |
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