In(OTf) 3 -catalyzed N -α phosphonylation of N , O -acetals with triethyl phosphite

A practical approach to α-aminophosphonates has been developed through an In(OTf) 3 -catalyzed N -α phosphonylation of N , O -acetals with triethyl phosphite 7. Indoline and isoindoline N , O -acetals 6a–6j and 9a–9j and chain N , O -acetals 11a–11p were subjected to a Lewis acid catalyzed N -α phos...

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Veröffentlicht in:	Organic & biomolecular chemistry 2022-08, Vol.20 (33), p.6571-6581
Hauptverfasser:	Sun, Jian-Ting, Li, Xin, Yang, Tian-Yu, Lv, Min, Chen, Ling-Yan, Wei, Bang-Guo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetals Lewis acid
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creator	Sun, Jian-Ting Li, Xin Yang, Tian-Yu Lv, Min Chen, Ling-Yan Wei, Bang-Guo
description	A practical approach to α-aminophosphonates has been developed through an In(OTf) 3 -catalyzed N -α phosphonylation of N , O -acetals with triethyl phosphite 7. Indoline and isoindoline N , O -acetals 6a–6j and 9a–9j and chain N , O -acetals 11a–11p were subjected to a Lewis acid catalyzed N -α phosphonylation process. As a result, the desired α-aminophosphonates 8a–8j, 10a–10j and 12a–12p were obtained in moderate to good yields.
doi_str_mv	10.1039/d2ob01196d
format	Article
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title	In(OTf) 3 -catalyzed N -α phosphonylation of N , O -acetals with triethyl phosphite
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