Outcome of pallidal deep brain stimulation for treating isolated orofacial dystonia
Background Isolated orofacial dystonia is a rare segmental neurological disorder that affects the eye, mouth, face, and jaws. Current literature on pallidal surgery for orofacial dystonia is limited to case reports and small-scale studies. This study was to investigate clinical outcomes of deep brai...
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| Veröffentlicht in: | Acta neurochirurgica 2022-09, Vol.164 (9), p.2287-2298 |
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| creator | Huh, Ryoong Chung, Moonyoung Jang, Il |
| description | Background
Isolated orofacial dystonia is a rare segmental neurological disorder that affects the eye, mouth, face, and jaws. Current literature on pallidal surgery for orofacial dystonia is limited to case reports and small-scale studies. This study was to investigate clinical outcomes of deep brain stimulation (DBS) of the globus pallidus internus (GPi) in patients with isolated orofacial dystonia.
Methods
Thirty-six patients who underwent GPi DBS at Incheon St. Mary’s Hospital, The Catholic University of Korea, between 2014 and 2019 were included in this study. Burke-Fahn-Marsden Dystonia Rating Scale, Unified Dystonia Rating Scale, and Global Dystonia Severity Rating Scale were retrospectively retrieved for analysis before surgery, at 6-month follow-up as short-term outcome, and at follow-up over 1 year (12 months to 69 months) as long-term results.
Results
Mean total BFMDRS-M scores at the three time points (baseline, 6 months, and over 1 year follow-up) were 11.6 ± 4.9, 6.1 ± 5.2 (50.3 ± 29.9% improvement,
p
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| doi_str_mv | 10.1007/s00701-022-05320-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2696005699</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2708084220</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-e3d5148fb9d13046c367d4165c080488ba11ba950baba7e0124ccbf37b168423</originalsourceid><addsrcrecordid>eNp9kLlOAzEQhi0EIhB4AQpkiYZmYXzs4RJFXFKkFKS3bK83crS7DvZukbfHIeEQBY3HM_PNP6MfoSsCdwSgvI_pAZIBpRnkjEImjtAZCJ5SweH413-CzmNcAxBacnaKJiyvRFHR6gy9LcbB-M5i3-CNaltXqxbX1m6wDsr1OA6uG1s1ON_jxgc8BJuSfoVd9Klsa-yDb5Rxu7FtHHzv1AU6aVQb7eUhTtHy6XE5e8nmi-fX2cM8M6zMh8yyOie8arSoCQNeGFaUNSdFbqACXlVaEaKVyEErrUqbjufG6IaVmhQVp2yKbveym-DfRxsH2blobNuq3voxSlqIAiAvhEjozR907cfQp-MkLdO2JEchUXRPmeBjDLaRm-A6FbaSgNw5LveOy-S4_HRc7qSvD9Kj7mz9PfJlcQLYHoip1a9s-Nn9j-wHt6iLHA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2708084220</pqid></control><display><type>article</type><title>Outcome of pallidal deep brain stimulation for treating isolated orofacial dystonia</title><source>MEDLINE</source><source>SpringerNature Complete Journals</source><creator>Huh, Ryoong ; Chung, Moonyoung ; Jang, Il</creator><creatorcontrib>Huh, Ryoong ; Chung, Moonyoung ; Jang, Il</creatorcontrib><description><![CDATA[Background
Isolated orofacial dystonia is a rare segmental neurological disorder that affects the eye, mouth, face, and jaws. Current literature on pallidal surgery for orofacial dystonia is limited to case reports and small-scale studies. This study was to investigate clinical outcomes of deep brain stimulation (DBS) of the globus pallidus internus (GPi) in patients with isolated orofacial dystonia.
Methods
Thirty-six patients who underwent GPi DBS at Incheon St. Mary’s Hospital, The Catholic University of Korea, between 2014 and 2019 were included in this study. Burke-Fahn-Marsden Dystonia Rating Scale, Unified Dystonia Rating Scale, and Global Dystonia Severity Rating Scale were retrospectively retrieved for analysis before surgery, at 6-month follow-up as short-term outcome, and at follow-up over 1 year (12 months to 69 months) as long-term results.
Results
Mean total BFMDRS-M scores at the three time points (baseline, 6 months, and over 1 year follow-up) were 11.6 ± 4.9, 6.1 ± 5.2 (50.3 ± 29.9% improvement,
p
< 0.05), and 4.3 ± 4.2 (65.0 ± 24.2% improvement,
p
< 0.05), respectively. In terms of UDRS and GDS, improvement rates were 45.1% (
p
< 0.001) and 47.7% (p < 0.001) at 6 months, and 63.8% (
p
< 0.001) and 65.7% (
p
< 0.001) at over 1 year after surgery, respectively.
Conclusions
Bilateral GPi DBS in isolated orofacial dystonia can be effective if conservative treatment option fails. Its benefit is not only observed in a short term, but also maintained in a long-term follow-up.]]></description><identifier>ISSN: 0942-0940</identifier><identifier>ISSN: 0001-6268</identifier><identifier>EISSN: 0942-0940</identifier><identifier>DOI: 10.1007/s00701-022-05320-9</identifier><identifier>PMID: 35896828</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Case reports ; Deep brain stimulation ; Deep Brain Stimulation - methods ; Dystonia ; Dystonia - therapy ; Functional Neurosurgery – Movement disorders ; Globus pallidus ; Globus Pallidus - physiology ; Humans ; Interventional Radiology ; Medicine ; Medicine & Public Health ; Minimally Invasive Surgery ; Neurology ; Neuroradiology ; Neurosurgery ; Original Article - Functional Neurosurgery - Movement disorders ; Patients ; Retrospective Studies ; Surgery ; Surgical Orthopedics ; Treatment Outcome</subject><ispartof>Acta neurochirurgica, 2022-09, Vol.164 (9), p.2287-2298</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-e3d5148fb9d13046c367d4165c080488ba11ba950baba7e0124ccbf37b168423</citedby><cites>FETCH-LOGICAL-c375t-e3d5148fb9d13046c367d4165c080488ba11ba950baba7e0124ccbf37b168423</cites><orcidid>0000-0002-3288-6139</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00701-022-05320-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00701-022-05320-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35896828$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huh, Ryoong</creatorcontrib><creatorcontrib>Chung, Moonyoung</creatorcontrib><creatorcontrib>Jang, Il</creatorcontrib><title>Outcome of pallidal deep brain stimulation for treating isolated orofacial dystonia</title><title>Acta neurochirurgica</title><addtitle>Acta Neurochir</addtitle><addtitle>Acta Neurochir (Wien)</addtitle><description><![CDATA[Background
Isolated orofacial dystonia is a rare segmental neurological disorder that affects the eye, mouth, face, and jaws. Current literature on pallidal surgery for orofacial dystonia is limited to case reports and small-scale studies. This study was to investigate clinical outcomes of deep brain stimulation (DBS) of the globus pallidus internus (GPi) in patients with isolated orofacial dystonia.
Methods
Thirty-six patients who underwent GPi DBS at Incheon St. Mary’s Hospital, The Catholic University of Korea, between 2014 and 2019 were included in this study. Burke-Fahn-Marsden Dystonia Rating Scale, Unified Dystonia Rating Scale, and Global Dystonia Severity Rating Scale were retrospectively retrieved for analysis before surgery, at 6-month follow-up as short-term outcome, and at follow-up over 1 year (12 months to 69 months) as long-term results.
Results
Mean total BFMDRS-M scores at the three time points (baseline, 6 months, and over 1 year follow-up) were 11.6 ± 4.9, 6.1 ± 5.2 (50.3 ± 29.9% improvement,
p
< 0.05), and 4.3 ± 4.2 (65.0 ± 24.2% improvement,
p
< 0.05), respectively. In terms of UDRS and GDS, improvement rates were 45.1% (
p
< 0.001) and 47.7% (p < 0.001) at 6 months, and 63.8% (
p
< 0.001) and 65.7% (
p
< 0.001) at over 1 year after surgery, respectively.
Conclusions
Bilateral GPi DBS in isolated orofacial dystonia can be effective if conservative treatment option fails. Its benefit is not only observed in a short term, but also maintained in a long-term follow-up.]]></description><subject>Case reports</subject><subject>Deep brain stimulation</subject><subject>Deep Brain Stimulation - methods</subject><subject>Dystonia</subject><subject>Dystonia - therapy</subject><subject>Functional Neurosurgery – Movement disorders</subject><subject>Globus pallidus</subject><subject>Globus Pallidus - physiology</subject><subject>Humans</subject><subject>Interventional Radiology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Minimally Invasive Surgery</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosurgery</subject><subject>Original Article - Functional Neurosurgery - Movement disorders</subject><subject>Patients</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgical Orthopedics</subject><subject>Treatment Outcome</subject><issn>0942-0940</issn><issn>0001-6268</issn><issn>0942-0940</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kLlOAzEQhi0EIhB4AQpkiYZmYXzs4RJFXFKkFKS3bK83crS7DvZukbfHIeEQBY3HM_PNP6MfoSsCdwSgvI_pAZIBpRnkjEImjtAZCJ5SweH413-CzmNcAxBacnaKJiyvRFHR6gy9LcbB-M5i3-CNaltXqxbX1m6wDsr1OA6uG1s1ON_jxgc8BJuSfoVd9Klsa-yDb5Rxu7FtHHzv1AU6aVQb7eUhTtHy6XE5e8nmi-fX2cM8M6zMh8yyOie8arSoCQNeGFaUNSdFbqACXlVaEaKVyEErrUqbjufG6IaVmhQVp2yKbveym-DfRxsH2blobNuq3voxSlqIAiAvhEjozR907cfQp-MkLdO2JEchUXRPmeBjDLaRm-A6FbaSgNw5LveOy-S4_HRc7qSvD9Kj7mz9PfJlcQLYHoip1a9s-Nn9j-wHt6iLHA</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Huh, Ryoong</creator><creator>Chung, Moonyoung</creator><creator>Jang, Il</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3288-6139</orcidid></search><sort><creationdate>20220901</creationdate><title>Outcome of pallidal deep brain stimulation for treating isolated orofacial dystonia</title><author>Huh, Ryoong ; Chung, Moonyoung ; Jang, Il</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-e3d5148fb9d13046c367d4165c080488ba11ba950baba7e0124ccbf37b168423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Case reports</topic><topic>Deep brain stimulation</topic><topic>Deep Brain Stimulation - methods</topic><topic>Dystonia</topic><topic>Dystonia - therapy</topic><topic>Functional Neurosurgery – Movement disorders</topic><topic>Globus pallidus</topic><topic>Globus Pallidus - physiology</topic><topic>Humans</topic><topic>Interventional Radiology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Minimally Invasive Surgery</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosurgery</topic><topic>Original Article - Functional Neurosurgery - Movement disorders</topic><topic>Patients</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgical Orthopedics</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huh, Ryoong</creatorcontrib><creatorcontrib>Chung, Moonyoung</creatorcontrib><creatorcontrib>Jang, Il</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neurochirurgica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huh, Ryoong</au><au>Chung, Moonyoung</au><au>Jang, Il</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcome of pallidal deep brain stimulation for treating isolated orofacial dystonia</atitle><jtitle>Acta neurochirurgica</jtitle><stitle>Acta Neurochir</stitle><addtitle>Acta Neurochir (Wien)</addtitle><date>2022-09-01</date><risdate>2022</risdate><volume>164</volume><issue>9</issue><spage>2287</spage><epage>2298</epage><pages>2287-2298</pages><issn>0942-0940</issn><issn>0001-6268</issn><eissn>0942-0940</eissn><abstract><![CDATA[Background
Isolated orofacial dystonia is a rare segmental neurological disorder that affects the eye, mouth, face, and jaws. Current literature on pallidal surgery for orofacial dystonia is limited to case reports and small-scale studies. This study was to investigate clinical outcomes of deep brain stimulation (DBS) of the globus pallidus internus (GPi) in patients with isolated orofacial dystonia.
Methods
Thirty-six patients who underwent GPi DBS at Incheon St. Mary’s Hospital, The Catholic University of Korea, between 2014 and 2019 were included in this study. Burke-Fahn-Marsden Dystonia Rating Scale, Unified Dystonia Rating Scale, and Global Dystonia Severity Rating Scale were retrospectively retrieved for analysis before surgery, at 6-month follow-up as short-term outcome, and at follow-up over 1 year (12 months to 69 months) as long-term results.
Results
Mean total BFMDRS-M scores at the three time points (baseline, 6 months, and over 1 year follow-up) were 11.6 ± 4.9, 6.1 ± 5.2 (50.3 ± 29.9% improvement,
p
< 0.05), and 4.3 ± 4.2 (65.0 ± 24.2% improvement,
p
< 0.05), respectively. In terms of UDRS and GDS, improvement rates were 45.1% (
p
< 0.001) and 47.7% (p < 0.001) at 6 months, and 63.8% (
p
< 0.001) and 65.7% (
p
< 0.001) at over 1 year after surgery, respectively.
Conclusions
Bilateral GPi DBS in isolated orofacial dystonia can be effective if conservative treatment option fails. Its benefit is not only observed in a short term, but also maintained in a long-term follow-up.]]></abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>35896828</pmid><doi>10.1007/s00701-022-05320-9</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-3288-6139</orcidid></addata></record> |
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| subjects | Case reports Deep brain stimulation Deep Brain Stimulation - methods Dystonia Dystonia - therapy Functional Neurosurgery – Movement disorders Globus pallidus Globus Pallidus - physiology Humans Interventional Radiology Medicine Medicine & Public Health Minimally Invasive Surgery Neurology Neuroradiology Neurosurgery Original Article - Functional Neurosurgery - Movement disorders Patients Retrospective Studies Surgery Surgical Orthopedics Treatment Outcome |
| title | Outcome of pallidal deep brain stimulation for treating isolated orofacial dystonia |
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