Bacillus coagulans TBC169 probiotics for the recovery of intestinal function after gynecological laparoscopic surgery: a randomized, placebo-controlled trial
Background Evidence suggests that Bacillus coagulans TBC169 can improve intestinal motility. Aim To investigate the effectiveness and safety of Bacillus coagulans TBC169 probiotics in promoting the recovery of intestinal function after gynecological laparoscopic surgery. Method Patients who underwen...
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| Veröffentlicht in: | International journal of clinical pharmacy 2022-12, Vol.44 (6), p.1287-1295 |
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| container_title | International journal of clinical pharmacy |
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| creator | Li, Zhihong Guan, Zhaobo Bai, Niuniu Yan, Ya Niu, Zhanqin Xu, Juan Gao, Weiqi Chen, Weihong |
| description | Background
Evidence suggests that
Bacillus coagulans
TBC169 can improve intestinal motility.
Aim
To investigate the effectiveness and safety of
Bacillus coagulans
TBC169 probiotics in promoting the recovery of intestinal function after gynecological laparoscopic surgery.
Method
Patients who underwent laparoscopic surgeries due to gynecological diseases were randomly assigned to the high-dose, conventional-dose, and the placebo-control groups (1:1:1 ratio). The primary outcome was the time to the first passage of flatus time (FFT). Secondary outcomes were the time to the first defecation (FDT), the time to the first bowel sounds (TFBS), the duration of hospital stay (DHS), and the incidence of postoperative adverse events (AEs).
Results
Compared to the placebo-control group, shorter FFT values were observed in the conventional-dose (23.15 h
vs.
29.10 h,
P
|
| doi_str_mv | 10.1007/s11096-022-01451-2 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2695294436</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A728714365</galeid><sourcerecordid>A728714365</sourcerecordid><originalsourceid>FETCH-LOGICAL-c349t-6147a47905d478a6e7a9d28e526ec264fdf6a561e2417535bdf6e82799bbcdd13</originalsourceid><addsrcrecordid>eNp9ks9qFTEUxgdRsNS-gKuAGxdOTTKZZMZde9FWKLip65DJnIwpucmYZITbd_FdPfWKRRGTRf79vkPOx9c0Lxk9Z5Sqt4UxOsqWct5SJnrW8ifNCeeMtkox9vT3nnbPm7NS7igOITnrxUnz_dJYH8JWiE1m2YKJhdxe7pgcyZrT5FP1thCXMqlfgGSw6RvkA0mO-FihVB9NIG6LtvoUiXEVMlkOEbmQFm_xMZjV5FRsWr0lZcsL6t8RQ7KJc9r7e5jfkDUYC1NqbYo1pxBgJjV7E140z5wJBc5-rafN5w_vb3fX7c2nq4-7i5vWdmKsrWRCGaFG2s9CDUaCMuPMB-i5BMulcLOTppcMuGCq7_oJzzBwNY7TZOeZdafN62Nd7Pnrhm3pvS8WAtoBaSuay7HnoxCdRPTVX-hd2jK6gJRC84euo-yRWkwA7aNLNRv7UFRfKD4ohqV6pM7_QeGcYe_RC3Ae7_8Q8KPAoqMlg9Nr9nuTD5pR_ZAFfcyCxizon1nQHEXdUVQQjmj_44__o_oBoQ63hg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2745183301</pqid></control><display><type>article</type><title>Bacillus coagulans TBC169 probiotics for the recovery of intestinal function after gynecological laparoscopic surgery: a randomized, placebo-controlled trial</title><source>SpringerLink Journals - AutoHoldings</source><creator>Li, Zhihong ; Guan, Zhaobo ; Bai, Niuniu ; Yan, Ya ; Niu, Zhanqin ; Xu, Juan ; Gao, Weiqi ; Chen, Weihong</creator><creatorcontrib>Li, Zhihong ; Guan, Zhaobo ; Bai, Niuniu ; Yan, Ya ; Niu, Zhanqin ; Xu, Juan ; Gao, Weiqi ; Chen, Weihong</creatorcontrib><description><![CDATA[Background
Evidence suggests that
Bacillus coagulans
TBC169 can improve intestinal motility.
Aim
To investigate the effectiveness and safety of
Bacillus coagulans
TBC169 probiotics in promoting the recovery of intestinal function after gynecological laparoscopic surgery.
Method
Patients who underwent laparoscopic surgeries due to gynecological diseases were randomly assigned to the high-dose, conventional-dose, and the placebo-control groups (1:1:1 ratio). The primary outcome was the time to the first passage of flatus time (FFT). Secondary outcomes were the time to the first defecation (FDT), the time to the first bowel sounds (TFBS), the duration of hospital stay (DHS), and the incidence of postoperative adverse events (AEs).
Results
Compared to the placebo-control group, shorter FFT values were observed in the conventional-dose (23.15 h
vs.
29.10 h,
P
< 0.05) and high-dose (19.15 h
vs.
29.10 h,
P
< 0.001) groups. Similar trends were observed regarding TFBS in the conventional-dose (18.50 h
vs.
21.10 h,
P
< 0.05) and high-dose (15.20 h
vs.
21.10 h,
P
< 0.001) groups. There were no significant differences in FFT and TFBS between the intervention groups. Compared to the placebo-control group, lower incidences of postoperative adverse events were observed in the conventional-dose (12.50%
vs.
40.00%,
P
< 0.05) and the high-dose (5.00%
vs.
40.00%,
P
< 0.001) groups. However, there were no significant differences between these intervention groups.
Conclusion
Bacillus coagulans
TBC169 probiotics can accelerate intestinal function recovery, and reduce postoperative adverse events in patients after gynecological laparoscopic surgery.
The study protocol was registered at the Chinese Clinical Trial Registry (ChiCTR2200059518).]]></description><identifier>ISSN: 2210-7703</identifier><identifier>EISSN: 2210-7711</identifier><identifier>DOI: 10.1007/s11096-022-01451-2</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adverse events ; Bacillus coagulans ; Clinical trials ; Defecation ; Gynecological diseases ; Gynecology ; Internal Medicine ; Intestinal motility ; Intestine ; Laparoscopic surgery ; Laparoscopy ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Patients ; Pharmacy ; Placebos ; Probiotics ; Research Article ; Surgery</subject><ispartof>International journal of clinical pharmacy, 2022-12, Vol.44 (6), p.1287-1295</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022. corrected publication 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>COPYRIGHT 2022 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-6147a47905d478a6e7a9d28e526ec264fdf6a561e2417535bdf6e82799bbcdd13</citedby><cites>FETCH-LOGICAL-c349t-6147a47905d478a6e7a9d28e526ec264fdf6a561e2417535bdf6e82799bbcdd13</cites><orcidid>0000-0002-2972-1069</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11096-022-01451-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11096-022-01451-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Li, Zhihong</creatorcontrib><creatorcontrib>Guan, Zhaobo</creatorcontrib><creatorcontrib>Bai, Niuniu</creatorcontrib><creatorcontrib>Yan, Ya</creatorcontrib><creatorcontrib>Niu, Zhanqin</creatorcontrib><creatorcontrib>Xu, Juan</creatorcontrib><creatorcontrib>Gao, Weiqi</creatorcontrib><creatorcontrib>Chen, Weihong</creatorcontrib><title>Bacillus coagulans TBC169 probiotics for the recovery of intestinal function after gynecological laparoscopic surgery: a randomized, placebo-controlled trial</title><title>International journal of clinical pharmacy</title><addtitle>Int J Clin Pharm</addtitle><description><![CDATA[Background
Evidence suggests that
Bacillus coagulans
TBC169 can improve intestinal motility.
Aim
To investigate the effectiveness and safety of
Bacillus coagulans
TBC169 probiotics in promoting the recovery of intestinal function after gynecological laparoscopic surgery.
Method
Patients who underwent laparoscopic surgeries due to gynecological diseases were randomly assigned to the high-dose, conventional-dose, and the placebo-control groups (1:1:1 ratio). The primary outcome was the time to the first passage of flatus time (FFT). Secondary outcomes were the time to the first defecation (FDT), the time to the first bowel sounds (TFBS), the duration of hospital stay (DHS), and the incidence of postoperative adverse events (AEs).
Results
Compared to the placebo-control group, shorter FFT values were observed in the conventional-dose (23.15 h
vs.
29.10 h,
P
< 0.05) and high-dose (19.15 h
vs.
29.10 h,
P
< 0.001) groups. Similar trends were observed regarding TFBS in the conventional-dose (18.50 h
vs.
21.10 h,
P
< 0.05) and high-dose (15.20 h
vs.
21.10 h,
P
< 0.001) groups. There were no significant differences in FFT and TFBS between the intervention groups. Compared to the placebo-control group, lower incidences of postoperative adverse events were observed in the conventional-dose (12.50%
vs.
40.00%,
P
< 0.05) and the high-dose (5.00%
vs.
40.00%,
P
< 0.001) groups. However, there were no significant differences between these intervention groups.
Conclusion
Bacillus coagulans
TBC169 probiotics can accelerate intestinal function recovery, and reduce postoperative adverse events in patients after gynecological laparoscopic surgery.
The study protocol was registered at the Chinese Clinical Trial Registry (ChiCTR2200059518).]]></description><subject>Adverse events</subject><subject>Bacillus coagulans</subject><subject>Clinical trials</subject><subject>Defecation</subject><subject>Gynecological diseases</subject><subject>Gynecology</subject><subject>Internal Medicine</subject><subject>Intestinal motility</subject><subject>Intestine</subject><subject>Laparoscopic surgery</subject><subject>Laparoscopy</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Patients</subject><subject>Pharmacy</subject><subject>Placebos</subject><subject>Probiotics</subject><subject>Research Article</subject><subject>Surgery</subject><issn>2210-7703</issn><issn>2210-7711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9ks9qFTEUxgdRsNS-gKuAGxdOTTKZZMZde9FWKLip65DJnIwpucmYZITbd_FdPfWKRRGTRf79vkPOx9c0Lxk9Z5Sqt4UxOsqWct5SJnrW8ifNCeeMtkox9vT3nnbPm7NS7igOITnrxUnz_dJYH8JWiE1m2YKJhdxe7pgcyZrT5FP1thCXMqlfgGSw6RvkA0mO-FihVB9NIG6LtvoUiXEVMlkOEbmQFm_xMZjV5FRsWr0lZcsL6t8RQ7KJc9r7e5jfkDUYC1NqbYo1pxBgJjV7E140z5wJBc5-rafN5w_vb3fX7c2nq4-7i5vWdmKsrWRCGaFG2s9CDUaCMuPMB-i5BMulcLOTppcMuGCq7_oJzzBwNY7TZOeZdafN62Nd7Pnrhm3pvS8WAtoBaSuay7HnoxCdRPTVX-hd2jK6gJRC84euo-yRWkwA7aNLNRv7UFRfKD4ohqV6pM7_QeGcYe_RC3Ae7_8Q8KPAoqMlg9Nr9nuTD5pR_ZAFfcyCxizon1nQHEXdUVQQjmj_44__o_oBoQ63hg</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Li, Zhihong</creator><creator>Guan, Zhaobo</creator><creator>Bai, Niuniu</creator><creator>Yan, Ya</creator><creator>Niu, Zhanqin</creator><creator>Xu, Juan</creator><creator>Gao, Weiqi</creator><creator>Chen, Weihong</creator><general>Springer International Publishing</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2972-1069</orcidid></search><sort><creationdate>20221201</creationdate><title>Bacillus coagulans TBC169 probiotics for the recovery of intestinal function after gynecological laparoscopic surgery: a randomized, placebo-controlled trial</title><author>Li, Zhihong ; Guan, Zhaobo ; Bai, Niuniu ; Yan, Ya ; Niu, Zhanqin ; Xu, Juan ; Gao, Weiqi ; Chen, Weihong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-6147a47905d478a6e7a9d28e526ec264fdf6a561e2417535bdf6e82799bbcdd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adverse events</topic><topic>Bacillus coagulans</topic><topic>Clinical trials</topic><topic>Defecation</topic><topic>Gynecological diseases</topic><topic>Gynecology</topic><topic>Internal Medicine</topic><topic>Intestinal motility</topic><topic>Intestine</topic><topic>Laparoscopic surgery</topic><topic>Laparoscopy</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Patients</topic><topic>Pharmacy</topic><topic>Placebos</topic><topic>Probiotics</topic><topic>Research Article</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Zhihong</creatorcontrib><creatorcontrib>Guan, Zhaobo</creatorcontrib><creatorcontrib>Bai, Niuniu</creatorcontrib><creatorcontrib>Yan, Ya</creatorcontrib><creatorcontrib>Niu, Zhanqin</creatorcontrib><creatorcontrib>Xu, Juan</creatorcontrib><creatorcontrib>Gao, Weiqi</creatorcontrib><creatorcontrib>Chen, Weihong</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical pharmacy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Zhihong</au><au>Guan, Zhaobo</au><au>Bai, Niuniu</au><au>Yan, Ya</au><au>Niu, Zhanqin</au><au>Xu, Juan</au><au>Gao, Weiqi</au><au>Chen, Weihong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bacillus coagulans TBC169 probiotics for the recovery of intestinal function after gynecological laparoscopic surgery: a randomized, placebo-controlled trial</atitle><jtitle>International journal of clinical pharmacy</jtitle><stitle>Int J Clin Pharm</stitle><date>2022-12-01</date><risdate>2022</risdate><volume>44</volume><issue>6</issue><spage>1287</spage><epage>1295</epage><pages>1287-1295</pages><issn>2210-7703</issn><eissn>2210-7711</eissn><abstract><![CDATA[Background
Evidence suggests that
Bacillus coagulans
TBC169 can improve intestinal motility.
Aim
To investigate the effectiveness and safety of
Bacillus coagulans
TBC169 probiotics in promoting the recovery of intestinal function after gynecological laparoscopic surgery.
Method
Patients who underwent laparoscopic surgeries due to gynecological diseases were randomly assigned to the high-dose, conventional-dose, and the placebo-control groups (1:1:1 ratio). The primary outcome was the time to the first passage of flatus time (FFT). Secondary outcomes were the time to the first defecation (FDT), the time to the first bowel sounds (TFBS), the duration of hospital stay (DHS), and the incidence of postoperative adverse events (AEs).
Results
Compared to the placebo-control group, shorter FFT values were observed in the conventional-dose (23.15 h
vs.
29.10 h,
P
< 0.05) and high-dose (19.15 h
vs.
29.10 h,
P
< 0.001) groups. Similar trends were observed regarding TFBS in the conventional-dose (18.50 h
vs.
21.10 h,
P
< 0.05) and high-dose (15.20 h
vs.
21.10 h,
P
< 0.001) groups. There were no significant differences in FFT and TFBS between the intervention groups. Compared to the placebo-control group, lower incidences of postoperative adverse events were observed in the conventional-dose (12.50%
vs.
40.00%,
P
< 0.05) and the high-dose (5.00%
vs.
40.00%,
P
< 0.001) groups. However, there were no significant differences between these intervention groups.
Conclusion
Bacillus coagulans
TBC169 probiotics can accelerate intestinal function recovery, and reduce postoperative adverse events in patients after gynecological laparoscopic surgery.
The study protocol was registered at the Chinese Clinical Trial Registry (ChiCTR2200059518).]]></abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s11096-022-01451-2</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2972-1069</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2210-7703 |
| ispartof | International journal of clinical pharmacy, 2022-12, Vol.44 (6), p.1287-1295 |
| issn | 2210-7703 2210-7711 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2695294436 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Adverse events Bacillus coagulans Clinical trials Defecation Gynecological diseases Gynecology Internal Medicine Intestinal motility Intestine Laparoscopic surgery Laparoscopy Medical research Medicine Medicine & Public Health Medicine, Experimental Patients Pharmacy Placebos Probiotics Research Article Surgery |
| title | Bacillus coagulans TBC169 probiotics for the recovery of intestinal function after gynecological laparoscopic surgery: a randomized, placebo-controlled trial |
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