Decellularized organ biomatrices facilitate quantifiable in vitro 3D cancer metastasis models

Metastatic cancers are chemoresistant, involving complex interplay between disseminated cancer cell aggregates and the distant organ microenvironment (extracellular matrix and stromal cells). Conventional metastasis surrogates (scratch/wound healing, Transwell migration assays) lack 3D architecture...

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Veröffentlicht in:	Soft matter 2022-08, Vol.18 (31), p.5791-5806
Hauptverfasser:	VandenHeuvel, Sabrina N., Farris, Heather A., Noltensmeyer, Dillon A., Roy, Sanjana, Donehoo, Del A., Kopetz, Scott, Haricharan, Svasti, Walsh, Alex J., Raghavan, Shreya
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor agents Biomimetics Breast cancer Chemoresistance Colonization Colorectal carcinoma Extracellular matrix Hepatocytes Liver Liver cancer Lung cancer Lungs Matrix metalloproteinase Matrix metalloproteinases Mesenchyme Metalloproteinase Metastases Metastasis Metastatic seeding Microenvironments Oxaliplatin Scaffolds Spheroids Stromal cells Target recognition Therapeutic targets Three dimensional models Tumors Wound healing
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