Synthesis of 4‑Tetrazolyl-Substituted 3,4-Dihydroquinazoline Derivatives with Anticancer Activity via a One-Pot Sequential Ugi-Azide/Palladium-Catalyzed Azide-Isocyanide Cross-Coupling/Cyclization Reaction

A new one-pot preparation of 4-tetrazolyl-3,4-dihydroquinazolines has been reported. The Ugi-azide reactions of 2-azidobenzaldehydes, amines, trimethylsilyl azide, and isocyanides produced azide intermediates without separation, which were treated with isocyanides to give 4-tetrazolyl-3,4-dihydroqui...

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Veröffentlicht in:	Journal of organic chemistry 2022-08, Vol.87 (15), p.9488-9496
Hauptverfasser:	Xiong, Jun, He, Hui-Ting, Yang, He-Yu, Zeng, Zhi-Gang, Zhong, Cheng-Ran, Shi, Hang, Ouyang, Meng-Ling, Tao, Yuan-Yuan, Pang, Yong-Long, Zhang, Yang-Hong, Hu, Bo, Fu, Zi-Xiang, Miao, Xiao-Lei, Zhu, Hai-Li, Yao, Gang
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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