Polymer source affects in vitro-in vivo correlation of leuprolide acetate PLGA microspheres

[Display omitted] Poly(lactic-co-glycolic acid) PLGA (release controlling excipient) plays a dominant role on the performance of PLGA based long-acting parenterals. These types of drug products typically exhibit complex multi-phasic in vitro/in vivo release/absorption characteristics. In particular,...

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Veröffentlicht in:	International journal of pharmaceutics 2022-09, Vol.625, p.122032-122032, Article 122032
Hauptverfasser:	Wan, Bo, Bao, Quanying, Wang, Ruifeng, Burgess, Diane J.
Format:	Artikel
Sprache:	eng
Schlagworte:	In vitro release testing In vitro-in vivo correlation (IVIVC) Leuprolide acetate microspheres PLGA Polymer blockiness
Online-Zugang:	Volltext
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