Increasing rates of venous thromboembolism among hospitalised patients with inflammatory bowel disease: a nationwide analysis
Summary Background Venous thromboembolism (VTE) is a significant cause of morbidity and mortality among patients with inflammatory bowel disease (IBD). However, data on national trends remain limited. Aims To assess national trends in VTE‐associated hospitalisations among patients with IBD as well a...
Gespeichert in:
| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2022-10, Vol.56 (7), p.1157-1167 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1167 |
|---|---|
| container_issue | 7 |
| container_start_page | 1157 |
| container_title | Alimentary pharmacology & therapeutics |
| container_volume | 56 |
| creator | Faye, Adam S. Lee, Kate E. Dodson, John Chodosh, Joshua Hudesman, David Remzi, Feza Wright, Jason D. Friedman, Alexander M. Shaukat, Aasma Wen, Timothy |
| description | Summary
Background
Venous thromboembolism (VTE) is a significant cause of morbidity and mortality among patients with inflammatory bowel disease (IBD). However, data on national trends remain limited.
Aims
To assess national trends in VTE‐associated hospitalisations among patients with IBD as well as risk factors for, and mortality associated with, these events
Methods
Using the U.S. Nationwide Inpatient Sample from 2000–2018, temporal trends in VTE were assessed using the National Cancer Institute's Joinpoint Regression Program with estimates presented as the average annual percent change (AAPC) with 95% confidence intervals (CIs).
Results
Between 2000 and 2018, there were 4,859,728 hospitalisations among patients with IBD, with 128,236 (2.6%) having a VTE, and 6352 associated deaths. The rate of VTE among hospitalised patients with IBD increased from 192 to 295 cases per 10,000 hospitalisations (AAPC 2.4%, 95%CI 1.4%, 3.4%, p |
| doi_str_mv | 10.1111/apt.17162 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2694962441</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2711077265</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3532-13ddcf430a339c65264fc1eee4237051964a4ff1af9bd4c3b5c99cd20d0ae05b3</originalsourceid><addsrcrecordid>eNp10U9rFDEYBvAgFrtWD34BCXjRw7T5N5mOt1LUFgr1UM_DO8kbN2UmGZNslz30u5u6bQ9CAyEQfjzkzUPIB86OeV0nsJRj3nEtXpEVl7ptBJP6NVkxoftGnHJ5SN7mfMsY0x0Tb8ihbE-7Xki-IveXwSSE7MNvmqBgptHROwxxk2lZpziPEeuefJ4pzLGqdcyLL1Bv0NIFisdQMt36sqY-uAnmGUpMOzrGLU7UVgYZv1KgodoYtt4ihQDTLvv8jhw4mDK-fzyPyK_v327OL5qr6x-X52dXjZGtFA2X1hqnJAMpe6NboZUzHBGVkB1rea8VKOc4uH60ysixNX1vrGCWAbJ2lEfk8z53SfHPBnMZZp8NThMErJMO9Z9Ur4VSvNJP_9HbuEn1vVV1nLOuE7qt6stemRRzTuiGJfkZ0m7gbHjoZKidDP86qfbjY-JmnNE-y6cSKjjZg62fcPdy0nD282Yf-Renw5ht</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2711077265</pqid></control><display><type>article</type><title>Increasing rates of venous thromboembolism among hospitalised patients with inflammatory bowel disease: a nationwide analysis</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Faye, Adam S. ; Lee, Kate E. ; Dodson, John ; Chodosh, Joshua ; Hudesman, David ; Remzi, Feza ; Wright, Jason D. ; Friedman, Alexander M. ; Shaukat, Aasma ; Wen, Timothy</creator><creatorcontrib>Faye, Adam S. ; Lee, Kate E. ; Dodson, John ; Chodosh, Joshua ; Hudesman, David ; Remzi, Feza ; Wright, Jason D. ; Friedman, Alexander M. ; Shaukat, Aasma ; Wen, Timothy</creatorcontrib><description>Summary
Background
Venous thromboembolism (VTE) is a significant cause of morbidity and mortality among patients with inflammatory bowel disease (IBD). However, data on national trends remain limited.
Aims
To assess national trends in VTE‐associated hospitalisations among patients with IBD as well as risk factors for, and mortality associated with, these events
Methods
Using the U.S. Nationwide Inpatient Sample from 2000–2018, temporal trends in VTE were assessed using the National Cancer Institute's Joinpoint Regression Program with estimates presented as the average annual percent change (AAPC) with 95% confidence intervals (CIs).
Results
Between 2000 and 2018, there were 4,859,728 hospitalisations among patients with IBD, with 128,236 (2.6%) having a VTE, and 6352 associated deaths. The rate of VTE among hospitalised patients with IBD increased from 192 to 295 cases per 10,000 hospitalisations (AAPC 2.4%, 95%CI 1.4%, 3.4%, p < 0.001), and remained significant when stratified by ulcerative colitis (UC) and Crohn's disease as well as by deep vein thrombosis and pulmonary embolism. On multivariable analysis, increasing age, male sex, UC (aOR: 1.30, 95%CI 1.26, 1.33), identifying as non‐Hispanic Black, and chronic corticosteroid use (aOR: 1.22, 95%CI 1.16, 1.29) were associated with an increased risk of a VTE‐associated hospitalisation.
Conclusion
Rates of VTE‐associated hospitalisations are increasing among patients with IBD. Continued efforts need to be placed on education and risk reduction.
Increasing Rates of Venous Thromboembolism Among Hospitalized Patients with Inflammatory Bowel Disease.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/apt.17162</identifier><identifier>PMID: 35879231</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Chronic Disease ; Colitis, Ulcerative - complications ; Colitis, Ulcerative - epidemiology ; Crohn Disease - complications ; Crohn Disease - epidemiology ; Crohn's disease ; deep vein thrombosis ; Embolism ; Hospitalization ; Humans ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Inflammatory Bowel Diseases - complications ; Inflammatory Bowel Diseases - epidemiology ; Intestine ; Male ; Morbidity ; Mortality ; prophylaxis ; Pulmonary Embolism ; Pulmonary embolisms ; Risk Factors ; socioeconomic ; Thromboembolism ; Thrombosis ; Trends ; Ulcerative colitis ; Venous Thromboembolism - epidemiology ; Venous Thromboembolism - etiology</subject><ispartof>Alimentary pharmacology & therapeutics, 2022-10, Vol.56 (7), p.1157-1167</ispartof><rights>2022 John Wiley & Sons Ltd.</rights><rights>Copyright © 2022 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-13ddcf430a339c65264fc1eee4237051964a4ff1af9bd4c3b5c99cd20d0ae05b3</citedby><cites>FETCH-LOGICAL-c3532-13ddcf430a339c65264fc1eee4237051964a4ff1af9bd4c3b5c99cd20d0ae05b3</cites><orcidid>0000-0002-0171-7121</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapt.17162$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapt.17162$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35879231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Faye, Adam S.</creatorcontrib><creatorcontrib>Lee, Kate E.</creatorcontrib><creatorcontrib>Dodson, John</creatorcontrib><creatorcontrib>Chodosh, Joshua</creatorcontrib><creatorcontrib>Hudesman, David</creatorcontrib><creatorcontrib>Remzi, Feza</creatorcontrib><creatorcontrib>Wright, Jason D.</creatorcontrib><creatorcontrib>Friedman, Alexander M.</creatorcontrib><creatorcontrib>Shaukat, Aasma</creatorcontrib><creatorcontrib>Wen, Timothy</creatorcontrib><title>Increasing rates of venous thromboembolism among hospitalised patients with inflammatory bowel disease: a nationwide analysis</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background
Venous thromboembolism (VTE) is a significant cause of morbidity and mortality among patients with inflammatory bowel disease (IBD). However, data on national trends remain limited.
Aims
To assess national trends in VTE‐associated hospitalisations among patients with IBD as well as risk factors for, and mortality associated with, these events
Methods
Using the U.S. Nationwide Inpatient Sample from 2000–2018, temporal trends in VTE were assessed using the National Cancer Institute's Joinpoint Regression Program with estimates presented as the average annual percent change (AAPC) with 95% confidence intervals (CIs).
Results
Between 2000 and 2018, there were 4,859,728 hospitalisations among patients with IBD, with 128,236 (2.6%) having a VTE, and 6352 associated deaths. The rate of VTE among hospitalised patients with IBD increased from 192 to 295 cases per 10,000 hospitalisations (AAPC 2.4%, 95%CI 1.4%, 3.4%, p < 0.001), and remained significant when stratified by ulcerative colitis (UC) and Crohn's disease as well as by deep vein thrombosis and pulmonary embolism. On multivariable analysis, increasing age, male sex, UC (aOR: 1.30, 95%CI 1.26, 1.33), identifying as non‐Hispanic Black, and chronic corticosteroid use (aOR: 1.22, 95%CI 1.16, 1.29) were associated with an increased risk of a VTE‐associated hospitalisation.
Conclusion
Rates of VTE‐associated hospitalisations are increasing among patients with IBD. Continued efforts need to be placed on education and risk reduction.
Increasing Rates of Venous Thromboembolism Among Hospitalized Patients with Inflammatory Bowel Disease.</description><subject>Chronic Disease</subject><subject>Colitis, Ulcerative - complications</subject><subject>Colitis, Ulcerative - epidemiology</subject><subject>Crohn Disease - complications</subject><subject>Crohn Disease - epidemiology</subject><subject>Crohn's disease</subject><subject>deep vein thrombosis</subject><subject>Embolism</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Inflammatory Bowel Diseases - complications</subject><subject>Inflammatory Bowel Diseases - epidemiology</subject><subject>Intestine</subject><subject>Male</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>prophylaxis</subject><subject>Pulmonary Embolism</subject><subject>Pulmonary embolisms</subject><subject>Risk Factors</subject><subject>socioeconomic</subject><subject>Thromboembolism</subject><subject>Thrombosis</subject><subject>Trends</subject><subject>Ulcerative colitis</subject><subject>Venous Thromboembolism - epidemiology</subject><subject>Venous Thromboembolism - etiology</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10U9rFDEYBvAgFrtWD34BCXjRw7T5N5mOt1LUFgr1UM_DO8kbN2UmGZNslz30u5u6bQ9CAyEQfjzkzUPIB86OeV0nsJRj3nEtXpEVl7ptBJP6NVkxoftGnHJ5SN7mfMsY0x0Tb8ihbE-7Xki-IveXwSSE7MNvmqBgptHROwxxk2lZpziPEeuefJ4pzLGqdcyLL1Bv0NIFisdQMt36sqY-uAnmGUpMOzrGLU7UVgYZv1KgodoYtt4ihQDTLvv8jhw4mDK-fzyPyK_v327OL5qr6x-X52dXjZGtFA2X1hqnJAMpe6NboZUzHBGVkB1rea8VKOc4uH60ysixNX1vrGCWAbJ2lEfk8z53SfHPBnMZZp8NThMErJMO9Z9Ur4VSvNJP_9HbuEn1vVV1nLOuE7qt6stemRRzTuiGJfkZ0m7gbHjoZKidDP86qfbjY-JmnNE-y6cSKjjZg62fcPdy0nD282Yf-Renw5ht</recordid><startdate>202210</startdate><enddate>202210</enddate><creator>Faye, Adam S.</creator><creator>Lee, Kate E.</creator><creator>Dodson, John</creator><creator>Chodosh, Joshua</creator><creator>Hudesman, David</creator><creator>Remzi, Feza</creator><creator>Wright, Jason D.</creator><creator>Friedman, Alexander M.</creator><creator>Shaukat, Aasma</creator><creator>Wen, Timothy</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0171-7121</orcidid></search><sort><creationdate>202210</creationdate><title>Increasing rates of venous thromboembolism among hospitalised patients with inflammatory bowel disease: a nationwide analysis</title><author>Faye, Adam S. ; Lee, Kate E. ; Dodson, John ; Chodosh, Joshua ; Hudesman, David ; Remzi, Feza ; Wright, Jason D. ; Friedman, Alexander M. ; Shaukat, Aasma ; Wen, Timothy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-13ddcf430a339c65264fc1eee4237051964a4ff1af9bd4c3b5c99cd20d0ae05b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Chronic Disease</topic><topic>Colitis, Ulcerative - complications</topic><topic>Colitis, Ulcerative - epidemiology</topic><topic>Crohn Disease - complications</topic><topic>Crohn Disease - epidemiology</topic><topic>Crohn's disease</topic><topic>deep vein thrombosis</topic><topic>Embolism</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory bowel diseases</topic><topic>Inflammatory Bowel Diseases - complications</topic><topic>Inflammatory Bowel Diseases - epidemiology</topic><topic>Intestine</topic><topic>Male</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>prophylaxis</topic><topic>Pulmonary Embolism</topic><topic>Pulmonary embolisms</topic><topic>Risk Factors</topic><topic>socioeconomic</topic><topic>Thromboembolism</topic><topic>Thrombosis</topic><topic>Trends</topic><topic>Ulcerative colitis</topic><topic>Venous Thromboembolism - epidemiology</topic><topic>Venous Thromboembolism - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Faye, Adam S.</creatorcontrib><creatorcontrib>Lee, Kate E.</creatorcontrib><creatorcontrib>Dodson, John</creatorcontrib><creatorcontrib>Chodosh, Joshua</creatorcontrib><creatorcontrib>Hudesman, David</creatorcontrib><creatorcontrib>Remzi, Feza</creatorcontrib><creatorcontrib>Wright, Jason D.</creatorcontrib><creatorcontrib>Friedman, Alexander M.</creatorcontrib><creatorcontrib>Shaukat, Aasma</creatorcontrib><creatorcontrib>Wen, Timothy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Faye, Adam S.</au><au>Lee, Kate E.</au><au>Dodson, John</au><au>Chodosh, Joshua</au><au>Hudesman, David</au><au>Remzi, Feza</au><au>Wright, Jason D.</au><au>Friedman, Alexander M.</au><au>Shaukat, Aasma</au><au>Wen, Timothy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increasing rates of venous thromboembolism among hospitalised patients with inflammatory bowel disease: a nationwide analysis</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2022-10</date><risdate>2022</risdate><volume>56</volume><issue>7</issue><spage>1157</spage><epage>1167</epage><pages>1157-1167</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Background
Venous thromboembolism (VTE) is a significant cause of morbidity and mortality among patients with inflammatory bowel disease (IBD). However, data on national trends remain limited.
Aims
To assess national trends in VTE‐associated hospitalisations among patients with IBD as well as risk factors for, and mortality associated with, these events
Methods
Using the U.S. Nationwide Inpatient Sample from 2000–2018, temporal trends in VTE were assessed using the National Cancer Institute's Joinpoint Regression Program with estimates presented as the average annual percent change (AAPC) with 95% confidence intervals (CIs).
Results
Between 2000 and 2018, there were 4,859,728 hospitalisations among patients with IBD, with 128,236 (2.6%) having a VTE, and 6352 associated deaths. The rate of VTE among hospitalised patients with IBD increased from 192 to 295 cases per 10,000 hospitalisations (AAPC 2.4%, 95%CI 1.4%, 3.4%, p < 0.001), and remained significant when stratified by ulcerative colitis (UC) and Crohn's disease as well as by deep vein thrombosis and pulmonary embolism. On multivariable analysis, increasing age, male sex, UC (aOR: 1.30, 95%CI 1.26, 1.33), identifying as non‐Hispanic Black, and chronic corticosteroid use (aOR: 1.22, 95%CI 1.16, 1.29) were associated with an increased risk of a VTE‐associated hospitalisation.
Conclusion
Rates of VTE‐associated hospitalisations are increasing among patients with IBD. Continued efforts need to be placed on education and risk reduction.
Increasing Rates of Venous Thromboembolism Among Hospitalized Patients with Inflammatory Bowel Disease.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35879231</pmid><doi>10.1111/apt.17162</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-0171-7121</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-2813 |
| ispartof | Alimentary pharmacology & therapeutics, 2022-10, Vol.56 (7), p.1157-1167 |
| issn | 0269-2813 1365-2036 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2694962441 |
| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Chronic Disease Colitis, Ulcerative - complications Colitis, Ulcerative - epidemiology Crohn Disease - complications Crohn Disease - epidemiology Crohn's disease deep vein thrombosis Embolism Hospitalization Humans Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - complications Inflammatory Bowel Diseases - epidemiology Intestine Male Morbidity Mortality prophylaxis Pulmonary Embolism Pulmonary embolisms Risk Factors socioeconomic Thromboembolism Thrombosis Trends Ulcerative colitis Venous Thromboembolism - epidemiology Venous Thromboembolism - etiology |
| title | Increasing rates of venous thromboembolism among hospitalised patients with inflammatory bowel disease: a nationwide analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T10%3A47%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increasing%20rates%20of%20venous%20thromboembolism%20among%20hospitalised%20patients%20with%20inflammatory%20bowel%20disease:%20a%20nationwide%20analysis&rft.jtitle=Alimentary%20pharmacology%20&%20therapeutics&rft.au=Faye,%20Adam%20S.&rft.date=2022-10&rft.volume=56&rft.issue=7&rft.spage=1157&rft.epage=1167&rft.pages=1157-1167&rft.issn=0269-2813&rft.eissn=1365-2036&rft_id=info:doi/10.1111/apt.17162&rft_dat=%3Cproquest_cross%3E2711077265%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2711077265&rft_id=info:pmid/35879231&rfr_iscdi=true |