Pathological classification of desmoplastic reaction is prognostic factor in cervical adenocarcinoma
Desmoplastic reaction (DR) and inflammation are significant pathological manifestations of tumorigenesis in several cancers. However, the correlation between these stromal reactions and cervical adenocarcinoma has been poorly documented. This investigation elucidated whether DR is a prognostic indic...
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| Veröffentlicht in: | Medical molecular morphology 2022-12, Vol.55 (4), p.275-282 |
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| creator | Akimoto, Taishi Takasawa, Akira Takasawa, Kumi Aoyama, Tomoyuki Matsuura, Motoki Tamate, Masato Iwasaki, Masahiro Habata, Shutaro Murakami, Taro Osanai, Makoto Saito, Tsuyoshi |
| description | Desmoplastic reaction (DR) and inflammation are significant pathological manifestations of tumorigenesis in several cancers. However, the correlation between these stromal reactions and cervical adenocarcinoma has been poorly documented. This investigation elucidated whether DR is a prognostic indicator in early cervical adenocarcinoma patients. Fifty-nine patients with early stage cervical adenocarcinoma (stages I/II) were included in the study. DR was divided into three groups, mature, intermediate, and immature, based on the presence of myxoid stroma and hyalinized keloid-like collagen. Inflammatory cell responses were classified as mild, moderate, and severe. Those stromal reactions were separately evaluated in the invasion front stroma and intratumoral stroma. In both the intratumor and invasion front stroma, intermediate/immature DR was correlated with tumor size,
T
stage,
N
stage, lymphovascular invasion, and parametrial infiltration (
p
|
| doi_str_mv | 10.1007/s00795-022-00329-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2694415749</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2729058836</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-6b437c1bb308285536d6169d504978006d52ce19786b7d3802d6b777fb060db13</originalsourceid><addsrcrecordid>eNp9kEtLxDAUhYMoOI7-AVcFN26qN48mzVIGXzCgC12HNEnHDG0zJh3Bf29mKgou3CSHc797uByEzjFcYQBxnfIjqxIIKQEokSU_QDNccygxk_LwR9dwjE5SWmdIcFLNkH3W41vowsob3RWm0yn5NuvRh6EIbWFd6sMm26M3RXTa7Ac-FZsYVkPY2212Qyz8UBgXP_ZB2rohGB2NH0KvT9FRq7vkzr7_OXq9u31ZPJTLp_vHxc2yNIyRseQNo8LgpqFQk7qqKLccc2krYFLUANxWxDicNW-EpTUQm4UQbQMcbIPpHF1Oufm4961Lo-p9Mq7r9ODCNinCJWO4Ekxm9OIPug7bOOTrFBFEQlXXlGeKTJSJIaXoWrWJvtfxU2FQu-LVVLzKxat98Wq3RKellOFh5eJv9D9bX2tzhhg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2729058836</pqid></control><display><type>article</type><title>Pathological classification of desmoplastic reaction is prognostic factor in cervical adenocarcinoma</title><source>Springer Online Journals Complete</source><creator>Akimoto, Taishi ; Takasawa, Akira ; Takasawa, Kumi ; Aoyama, Tomoyuki ; Matsuura, Motoki ; Tamate, Masato ; Iwasaki, Masahiro ; Habata, Shutaro ; Murakami, Taro ; Osanai, Makoto ; Saito, Tsuyoshi</creator><creatorcontrib>Akimoto, Taishi ; Takasawa, Akira ; Takasawa, Kumi ; Aoyama, Tomoyuki ; Matsuura, Motoki ; Tamate, Masato ; Iwasaki, Masahiro ; Habata, Shutaro ; Murakami, Taro ; Osanai, Makoto ; Saito, Tsuyoshi</creatorcontrib><description>Desmoplastic reaction (DR) and inflammation are significant pathological manifestations of tumorigenesis in several cancers. However, the correlation between these stromal reactions and cervical adenocarcinoma has been poorly documented. This investigation elucidated whether DR is a prognostic indicator in early cervical adenocarcinoma patients. Fifty-nine patients with early stage cervical adenocarcinoma (stages I/II) were included in the study. DR was divided into three groups, mature, intermediate, and immature, based on the presence of myxoid stroma and hyalinized keloid-like collagen. Inflammatory cell responses were classified as mild, moderate, and severe. Those stromal reactions were separately evaluated in the invasion front stroma and intratumoral stroma. In both the intratumor and invasion front stroma, intermediate/immature DR was correlated with tumor size,
T
stage,
N
stage, lymphovascular invasion, and parametrial infiltration (
p
< 0.001 to
p
< 0.05). In addition, in the intratumoral stroma, intermediate/immature DR led to short relapse-free survival and overall survival (
p
< 0.001). In the invasion front stroma, inflammatory cell responses were associated with DR immaturity and FIGO stage (
p
< 0.01). These results suggest that the classification of DR maturity is a potential prognostic biomarker in early stage cervical adenocarcinoma patients. DR can be evaluated by routine H&E staining without immunohistochemistry, making it convenient and economical in clinical practice.</description><identifier>ISSN: 1860-1480</identifier><identifier>EISSN: 1860-1499</identifier><identifier>DOI: 10.1007/s00795-022-00329-6</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Adenocarcinoma ; Anatomy ; Cancer ; Cervical cancer ; Collagen ; Immunohistochemistry ; Inflammation ; Medicine ; Medicine & Public Health ; Metastases ; Molecular Medicine ; Original Paper ; Pathology ; Patients ; Stroma ; Tumorigenesis</subject><ispartof>Medical molecular morphology, 2022-12, Vol.55 (4), p.275-282</ispartof><rights>The Author(s) under exclusive licence to The Japanese Society for Clinical Molecular Morphology 2022</rights><rights>The Author(s) under exclusive licence to The Japanese Society for Clinical Molecular Morphology 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-6b437c1bb308285536d6169d504978006d52ce19786b7d3802d6b777fb060db13</citedby><cites>FETCH-LOGICAL-c442t-6b437c1bb308285536d6169d504978006d52ce19786b7d3802d6b777fb060db13</cites><orcidid>0000-0003-0529-8910</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00795-022-00329-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00795-022-00329-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids></links><search><creatorcontrib>Akimoto, Taishi</creatorcontrib><creatorcontrib>Takasawa, Akira</creatorcontrib><creatorcontrib>Takasawa, Kumi</creatorcontrib><creatorcontrib>Aoyama, Tomoyuki</creatorcontrib><creatorcontrib>Matsuura, Motoki</creatorcontrib><creatorcontrib>Tamate, Masato</creatorcontrib><creatorcontrib>Iwasaki, Masahiro</creatorcontrib><creatorcontrib>Habata, Shutaro</creatorcontrib><creatorcontrib>Murakami, Taro</creatorcontrib><creatorcontrib>Osanai, Makoto</creatorcontrib><creatorcontrib>Saito, Tsuyoshi</creatorcontrib><title>Pathological classification of desmoplastic reaction is prognostic factor in cervical adenocarcinoma</title><title>Medical molecular morphology</title><addtitle>Med Mol Morphol</addtitle><description>Desmoplastic reaction (DR) and inflammation are significant pathological manifestations of tumorigenesis in several cancers. However, the correlation between these stromal reactions and cervical adenocarcinoma has been poorly documented. This investigation elucidated whether DR is a prognostic indicator in early cervical adenocarcinoma patients. Fifty-nine patients with early stage cervical adenocarcinoma (stages I/II) were included in the study. DR was divided into three groups, mature, intermediate, and immature, based on the presence of myxoid stroma and hyalinized keloid-like collagen. Inflammatory cell responses were classified as mild, moderate, and severe. Those stromal reactions were separately evaluated in the invasion front stroma and intratumoral stroma. In both the intratumor and invasion front stroma, intermediate/immature DR was correlated with tumor size,
T
stage,
N
stage, lymphovascular invasion, and parametrial infiltration (
p
< 0.001 to
p
< 0.05). In addition, in the intratumoral stroma, intermediate/immature DR led to short relapse-free survival and overall survival (
p
< 0.001). In the invasion front stroma, inflammatory cell responses were associated with DR immaturity and FIGO stage (
p
< 0.01). These results suggest that the classification of DR maturity is a potential prognostic biomarker in early stage cervical adenocarcinoma patients. DR can be evaluated by routine H&E staining without immunohistochemistry, making it convenient and economical in clinical practice.</description><subject>Adenocarcinoma</subject><subject>Anatomy</subject><subject>Cancer</subject><subject>Cervical cancer</subject><subject>Collagen</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Molecular Medicine</subject><subject>Original Paper</subject><subject>Pathology</subject><subject>Patients</subject><subject>Stroma</subject><subject>Tumorigenesis</subject><issn>1860-1480</issn><issn>1860-1499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLxDAUhYMoOI7-AVcFN26qN48mzVIGXzCgC12HNEnHDG0zJh3Bf29mKgou3CSHc797uByEzjFcYQBxnfIjqxIIKQEokSU_QDNccygxk_LwR9dwjE5SWmdIcFLNkH3W41vowsob3RWm0yn5NuvRh6EIbWFd6sMm26M3RXTa7Ac-FZsYVkPY2212Qyz8UBgXP_ZB2rohGB2NH0KvT9FRq7vkzr7_OXq9u31ZPJTLp_vHxc2yNIyRseQNo8LgpqFQk7qqKLccc2krYFLUANxWxDicNW-EpTUQm4UQbQMcbIPpHF1Oufm4961Lo-p9Mq7r9ODCNinCJWO4Ekxm9OIPug7bOOTrFBFEQlXXlGeKTJSJIaXoWrWJvtfxU2FQu-LVVLzKxat98Wq3RKellOFh5eJv9D9bX2tzhhg</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Akimoto, Taishi</creator><creator>Takasawa, Akira</creator><creator>Takasawa, Kumi</creator><creator>Aoyama, Tomoyuki</creator><creator>Matsuura, Motoki</creator><creator>Tamate, Masato</creator><creator>Iwasaki, Masahiro</creator><creator>Habata, Shutaro</creator><creator>Murakami, Taro</creator><creator>Osanai, Makoto</creator><creator>Saito, Tsuyoshi</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0529-8910</orcidid></search><sort><creationdate>20221201</creationdate><title>Pathological classification of desmoplastic reaction is prognostic factor in cervical adenocarcinoma</title><author>Akimoto, Taishi ; Takasawa, Akira ; Takasawa, Kumi ; Aoyama, Tomoyuki ; Matsuura, Motoki ; Tamate, Masato ; Iwasaki, Masahiro ; Habata, Shutaro ; Murakami, Taro ; Osanai, Makoto ; Saito, Tsuyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-6b437c1bb308285536d6169d504978006d52ce19786b7d3802d6b777fb060db13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adenocarcinoma</topic><topic>Anatomy</topic><topic>Cancer</topic><topic>Cervical cancer</topic><topic>Collagen</topic><topic>Immunohistochemistry</topic><topic>Inflammation</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Molecular Medicine</topic><topic>Original Paper</topic><topic>Pathology</topic><topic>Patients</topic><topic>Stroma</topic><topic>Tumorigenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akimoto, Taishi</creatorcontrib><creatorcontrib>Takasawa, Akira</creatorcontrib><creatorcontrib>Takasawa, Kumi</creatorcontrib><creatorcontrib>Aoyama, Tomoyuki</creatorcontrib><creatorcontrib>Matsuura, Motoki</creatorcontrib><creatorcontrib>Tamate, Masato</creatorcontrib><creatorcontrib>Iwasaki, Masahiro</creatorcontrib><creatorcontrib>Habata, Shutaro</creatorcontrib><creatorcontrib>Murakami, Taro</creatorcontrib><creatorcontrib>Osanai, Makoto</creatorcontrib><creatorcontrib>Saito, Tsuyoshi</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Medical molecular morphology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akimoto, Taishi</au><au>Takasawa, Akira</au><au>Takasawa, Kumi</au><au>Aoyama, Tomoyuki</au><au>Matsuura, Motoki</au><au>Tamate, Masato</au><au>Iwasaki, Masahiro</au><au>Habata, Shutaro</au><au>Murakami, Taro</au><au>Osanai, Makoto</au><au>Saito, Tsuyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathological classification of desmoplastic reaction is prognostic factor in cervical adenocarcinoma</atitle><jtitle>Medical molecular morphology</jtitle><stitle>Med Mol Morphol</stitle><date>2022-12-01</date><risdate>2022</risdate><volume>55</volume><issue>4</issue><spage>275</spage><epage>282</epage><pages>275-282</pages><issn>1860-1480</issn><eissn>1860-1499</eissn><abstract>Desmoplastic reaction (DR) and inflammation are significant pathological manifestations of tumorigenesis in several cancers. However, the correlation between these stromal reactions and cervical adenocarcinoma has been poorly documented. This investigation elucidated whether DR is a prognostic indicator in early cervical adenocarcinoma patients. Fifty-nine patients with early stage cervical adenocarcinoma (stages I/II) were included in the study. DR was divided into three groups, mature, intermediate, and immature, based on the presence of myxoid stroma and hyalinized keloid-like collagen. Inflammatory cell responses were classified as mild, moderate, and severe. Those stromal reactions were separately evaluated in the invasion front stroma and intratumoral stroma. In both the intratumor and invasion front stroma, intermediate/immature DR was correlated with tumor size,
T
stage,
N
stage, lymphovascular invasion, and parametrial infiltration (
p
< 0.001 to
p
< 0.05). In addition, in the intratumoral stroma, intermediate/immature DR led to short relapse-free survival and overall survival (
p
< 0.001). In the invasion front stroma, inflammatory cell responses were associated with DR immaturity and FIGO stage (
p
< 0.01). These results suggest that the classification of DR maturity is a potential prognostic biomarker in early stage cervical adenocarcinoma patients. DR can be evaluated by routine H&E staining without immunohistochemistry, making it convenient and economical in clinical practice.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><doi>10.1007/s00795-022-00329-6</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0529-8910</orcidid></addata></record> |
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| subjects | Adenocarcinoma Anatomy Cancer Cervical cancer Collagen Immunohistochemistry Inflammation Medicine Medicine & Public Health Metastases Molecular Medicine Original Paper Pathology Patients Stroma Tumorigenesis |
| title | Pathological classification of desmoplastic reaction is prognostic factor in cervical adenocarcinoma |
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