Leveraging epigenetics to enhance the efficacy of cancer-testis antigen: a potential candidate for immunotherapy

Ovarian cancer is the most lethal gynecological malignancy in women. The phenotype is characterized by delayed diagnosis, recurrence and drug resistance. Inherent immunogenicity potential, oncogenic function and expression of cancer-testis/germline antigen (CTA) in ovarian cancer render them a poten...

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Veröffentlicht in:	Epigenomics 2022-07, Vol.14 (14), p.865-886
Hauptverfasser:	Gupta, Rashmi, Jit, Bimal Prasad, Kumar, Santosh, Mittan, Sandeep, Tanwer, Pranay, Ray, M D, Mathur, Sandeep, Perumal, Vanamail, Kumar, Lalit, Rath, G K, Sharma, Ashok
Format:	Artikel
Sprache:	eng
Schlagworte:	cancer-testis antigen CAR-T cell dendritic cell DNA methylation epigenetic immunotherapy ovary cancer T cell TIL
Online-Zugang:	Volltext
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