Estimation of time to progression and post progression survival using joint modeling of summary level OS and PFS data with an ordinary differential equation model

Summary measures such as progression-free survival (PFS) and overall survival (OS) are commonly reported in literature for oncology trials, while time to progression (TTP) and post progression survival (PPS) are not usually reported. A time-variant transition hazard model was developed using an ordi...

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Veröffentlicht in:	Journal of pharmacokinetics and pharmacodynamics 2022-08, Vol.49 (4), p.455-469
Hauptverfasser:	Nagase, Mario, Doshi, Sameer, Dutta, Sandeep, Lin, Chih-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Immune checkpoint inhibitors Lung cancer Meta-analysis Non-small cell lung carcinoma Oncology Ordinary differential equations Original Paper Pharmacology/Toxicology Pharmacy Small cell lung carcinoma Veterinary Medicine/Veterinary Science
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