Structural insights revealed by the cocrystal structure of CCS1477 in complex with CBP bromodomain

Inhibition of the bromodomain of the CREB (cyclic-AMP response element-binding protein) binding protein (CBP) is a particularly promising new therapeutic approach for cancer. Benzimidazole derivatives CCS1477 and its analogues (8 and 9) are highly potent and selective CBP bromodomain inhibitors, wit...

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Veröffentlicht in:	Biochemical and biophysical research communications 2022-10, Vol.623, p.17-22
Hauptverfasser:	Xu, Hongrui, Luo, Guolong, Wu, Tianbang, Hu, Jiankang, Wang, Chao, Wu, Xishan, Zhang, Yan, Xu, Yong, Xiang, Qiuping
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzimidazole derivatives Bromodomain CBP CCS1477
Online-Zugang:	Volltext
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