Direct TLR2 Signaling Through mTOR and TBK1 Induces C/EBPβ and IRF7-Dependent Macrophage Differentiation in Hematopoietic Stem and Progenitor Cells

During an infection, hematopoiesis is altered to increase the output of mature myeloid cells to fight off the pathogen. Despite convincing evidence that hematopoietic stem and progenitor cells (HSPCs) can sense pathogens directly, more mechanistic studies are needed to reveal whether pattern recogni...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2022-10, Vol.40 (10), p.949-962
Hauptverfasser:	Bono, Cristina, Guerrero, Paula, Erades, Ana, Jordán-Pla, Antonio, Yáñez, Alberto, Gil, María Luisa
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!