Identification and Structure Analysis of an Unusual Halohydrin Dehalogenase for Highly Chemo‐, Regio‐ and Enantioselective Bio‐Nitration of Epoxides

We report the discovery of an unusual halohydrin dehalogenase, HHDHamb, that can work under relatively low acidic conditions and extremely low temperatures for the bio‐nitration of epoxides using nitrite as a nitrating agent. The bio‐nitration strategy exhibits high chemo‐, regio‐, and enantioselect...

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Veröffentlicht in:	Angewandte Chemie International Edition 2022-09, Vol.61 (37), p.e202205790-n/a
Hauptverfasser:	Wang, Hui‐Hui, Wan, Nan‐Wei, Miao, Run‐Ping, He, Cheng‐Li, Chen, Yong‐Zheng, Liu, Zhi‐Qiang, Zheng, Yu‐Guo
Format:	Artikel
Sprache:	eng
Schlagworte:	Bio-Nitration Biocatalysis Crystal structure Enantiomers Epoxides Halohydrin dehalogenase Low temperature Nitration Structural analysis β-Nitroalcohols
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