The two‐hit hypothesis in practice: Monozygotic twins with simultaneous hyperdiploid acute lymphoblastic leukemia

Approximately 25% of B‐cell acute lymphoblastic leukemia (B‐ALL) cases are defined by hyperdiploidy, with RAS mutations occurring in 30% of hyperdiploid B‐ALL patients. It is believed that hyperdiploidy is an in utero event with RAS mutations occurring postnatally, but clinical evidence of this is b...

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Veröffentlicht in:	Pediatric blood & cancer 2022-10, Vol.69 (10), p.e29885-n/a
Hauptverfasser:	Davidow, Kimberly, Mumanachit, Sarah, Mangum, David Spencer
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia B‐ALL genetics Hematology hyperdiploid Mutation Oncology Patients Pediatrics Twins
Online-Zugang:	Volltext
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