Decline in human T‐cell lymphotropic virus seroprevalence in blood donors from Minas Gerais, Brazil over a 12‐year period (2006–2017)
To investigate a 12‐year historical series (2006–2017) of human T‐cell lymphotropic virus (HTLV)‐positive blood donations from Fundação Hemominas, Minas Gerais, Brazil, an observational retrospective study was performed to evaluate data of blood donor candidates who were screened for HTLV‐1/2 by enz...
Gespeichert in:
| Veröffentlicht in: | Journal of medical virology 2022-11, Vol.94 (11), p.5535-5542 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 5542 |
|---|---|
| container_issue | 11 |
| container_start_page | 5535 |
| container_title | Journal of medical virology |
| container_volume | 94 |
| creator | Silva Malta, Maria Clara Fernandes Silva, Sônia Mara Nunes Oliveira, Milena Batista Ribeiro, Maisa Aparecida Martins, Marina Lobato |
| description | To investigate a 12‐year historical series (2006–2017) of human T‐cell lymphotropic virus (HTLV)‐positive blood donations from Fundação Hemominas, Minas Gerais, Brazil, an observational retrospective study was performed to evaluate data of blood donor candidates who were screened for HTLV‐1/2 by enzyme‐linked immunosorbent assay or chemiluminescence assays and confirmed by Western blot. We analyzed 3 309 716 blood donations covering 2006–2017 that were extracted from the institutional database. In a total of 3 308 738 donations that have complete algorithm tests, the global frequency of HTLV‐positive donations was 0.012%. The seroprevalence in first‐time blood donors was 28.82/100 000 donors; 0.95/100 000 donations were HTLV‐positive in repeat blood donors. The frequency of HTLV‐seropositive females was significantly higher than males (odds ratio = 1.85, p |
| doi_str_mv | 10.1002/jmv.28010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2692074181</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2692074181</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2830-ce127b643174c38c782d4c5b7494251251107856b9ba46674dc62791af0c149e3</originalsourceid><addsrcrecordid>eNp1kdFqFTEQhoMo9li98AUk4E0LbjuTzSbZy1q1Ki3eVG9DNptDc8hu1qR75HjVB_BC8AV8Fh-lT2LaU70QhIFh4JuPGX5CniIcIAA7XA3rA6YA4R5ZILSiakHifbIA5KISApsd8ijnFQColrGHZKduVNM0rF6Qb6-cDX501I_0Yh7MSM-vr75bFwINm2G6iJcpTt7StU9zptmVKbm1CW60tztdiLGnfRxjynSZ4kDP_GgyPXHJ-PyCvkzmqw80rl2i5tdPZMW-cSbRySVfNvcYgLi--sEA5f5j8mBpQnZP7vou-fjm9fnx2-r0w8m746PTyjJVQ2UdMtkJXqPktlZWKtZz23SSt5w1WApBqkZ0bWe4EJL3VjDZolmCRd66epfsbb1Tip9nly_14PPNz2Z0cc6aiZaB5KiwoM__QVdxTmO5TjOJNUNUkhdqf0vZFHNObqmn5AeTNhpB30SkS0T6NqLCPrszzt3g-r_kn0wKcLgFvvjgNv836fdnn7bK37Mnm3M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2713211874</pqid></control><display><type>article</type><title>Decline in human T‐cell lymphotropic virus seroprevalence in blood donors from Minas Gerais, Brazil over a 12‐year period (2006–2017)</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Silva Malta, Maria Clara Fernandes ; Silva, Sônia Mara Nunes ; Oliveira, Milena Batista ; Ribeiro, Maisa Aparecida ; Martins, Marina Lobato</creator><creatorcontrib>Silva Malta, Maria Clara Fernandes ; Silva, Sônia Mara Nunes ; Oliveira, Milena Batista ; Ribeiro, Maisa Aparecida ; Martins, Marina Lobato</creatorcontrib><description>To investigate a 12‐year historical series (2006–2017) of human T‐cell lymphotropic virus (HTLV)‐positive blood donations from Fundação Hemominas, Minas Gerais, Brazil, an observational retrospective study was performed to evaluate data of blood donor candidates who were screened for HTLV‐1/2 by enzyme‐linked immunosorbent assay or chemiluminescence assays and confirmed by Western blot. We analyzed 3 309 716 blood donations covering 2006–2017 that were extracted from the institutional database. In a total of 3 308 738 donations that have complete algorithm tests, the global frequency of HTLV‐positive donations was 0.012%. The seroprevalence in first‐time blood donors was 28.82/100 000 donors; 0.95/100 000 donations were HTLV‐positive in repeat blood donors. The frequency of HTLV‐seropositive females was significantly higher than males (odds ratio = 1.85, p < 0.001) in first‐time donors. The median age of HTLV‐positive first‐time and repeat donors was similar (36 and 32 years, respectively). First‐time donors ≥41 years had higher odds to be infected. There was a clear tendency of decline in the HTLV‐positive donations in the period analyzed, going from 19.26/100 000 donations to 8.50/100 000 donations. The increase in the proportion of repeat donors over the period analyzed (from 23% in 2006 to 67% in 2017) must be the principal factor that contributed to this drop. Our results showed a continuous decline in the frequency of HTLV‐positive donations from Minas Gerais, Brazil throughout 12 years and emphasize the importance of having a high rate of repeat donors in blood centers to reduce the residual risk of transfusion‐transmitted infections.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.28010</identifier><identifier>PMID: 35855523</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Algorithms ; Blood ; Blood & organ donations ; Blood Donors ; Blood transfusion ; Brazil - epidemiology ; Brazilian ; Chemiluminescence ; Female ; Health risks ; HTLV ; HTLV-I Infections - epidemiology ; HTLV-II Infections - epidemiology ; Human T-lymphotropic virus 1 ; Human T-lymphotropic virus 2 ; Humans ; Male ; Retrospective Studies ; Seroepidemiologic Studies ; Serology ; seroprevalence ; T-Lymphocytes ; Transfusion ; Virology ; Viruses</subject><ispartof>Journal of medical virology, 2022-11, Vol.94 (11), p.5535-5542</ispartof><rights>2022 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2830-ce127b643174c38c782d4c5b7494251251107856b9ba46674dc62791af0c149e3</citedby><cites>FETCH-LOGICAL-c2830-ce127b643174c38c782d4c5b7494251251107856b9ba46674dc62791af0c149e3</cites><orcidid>0000-0003-2506-8450</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.28010$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.28010$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35855523$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silva Malta, Maria Clara Fernandes</creatorcontrib><creatorcontrib>Silva, Sônia Mara Nunes</creatorcontrib><creatorcontrib>Oliveira, Milena Batista</creatorcontrib><creatorcontrib>Ribeiro, Maisa Aparecida</creatorcontrib><creatorcontrib>Martins, Marina Lobato</creatorcontrib><title>Decline in human T‐cell lymphotropic virus seroprevalence in blood donors from Minas Gerais, Brazil over a 12‐year period (2006–2017)</title><title>Journal of medical virology</title><addtitle>J Med Virol</addtitle><description>To investigate a 12‐year historical series (2006–2017) of human T‐cell lymphotropic virus (HTLV)‐positive blood donations from Fundação Hemominas, Minas Gerais, Brazil, an observational retrospective study was performed to evaluate data of blood donor candidates who were screened for HTLV‐1/2 by enzyme‐linked immunosorbent assay or chemiluminescence assays and confirmed by Western blot. We analyzed 3 309 716 blood donations covering 2006–2017 that were extracted from the institutional database. In a total of 3 308 738 donations that have complete algorithm tests, the global frequency of HTLV‐positive donations was 0.012%. The seroprevalence in first‐time blood donors was 28.82/100 000 donors; 0.95/100 000 donations were HTLV‐positive in repeat blood donors. The frequency of HTLV‐seropositive females was significantly higher than males (odds ratio = 1.85, p < 0.001) in first‐time donors. The median age of HTLV‐positive first‐time and repeat donors was similar (36 and 32 years, respectively). First‐time donors ≥41 years had higher odds to be infected. There was a clear tendency of decline in the HTLV‐positive donations in the period analyzed, going from 19.26/100 000 donations to 8.50/100 000 donations. The increase in the proportion of repeat donors over the period analyzed (from 23% in 2006 to 67% in 2017) must be the principal factor that contributed to this drop. Our results showed a continuous decline in the frequency of HTLV‐positive donations from Minas Gerais, Brazil throughout 12 years and emphasize the importance of having a high rate of repeat donors in blood centers to reduce the residual risk of transfusion‐transmitted infections.</description><subject>Algorithms</subject><subject>Blood</subject><subject>Blood & organ donations</subject><subject>Blood Donors</subject><subject>Blood transfusion</subject><subject>Brazil - epidemiology</subject><subject>Brazilian</subject><subject>Chemiluminescence</subject><subject>Female</subject><subject>Health risks</subject><subject>HTLV</subject><subject>HTLV-I Infections - epidemiology</subject><subject>HTLV-II Infections - epidemiology</subject><subject>Human T-lymphotropic virus 1</subject><subject>Human T-lymphotropic virus 2</subject><subject>Humans</subject><subject>Male</subject><subject>Retrospective Studies</subject><subject>Seroepidemiologic Studies</subject><subject>Serology</subject><subject>seroprevalence</subject><subject>T-Lymphocytes</subject><subject>Transfusion</subject><subject>Virology</subject><subject>Viruses</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kdFqFTEQhoMo9li98AUk4E0LbjuTzSbZy1q1Ki3eVG9DNptDc8hu1qR75HjVB_BC8AV8Fh-lT2LaU70QhIFh4JuPGX5CniIcIAA7XA3rA6YA4R5ZILSiakHifbIA5KISApsd8ijnFQColrGHZKduVNM0rF6Qb6-cDX501I_0Yh7MSM-vr75bFwINm2G6iJcpTt7StU9zptmVKbm1CW60tztdiLGnfRxjynSZ4kDP_GgyPXHJ-PyCvkzmqw80rl2i5tdPZMW-cSbRySVfNvcYgLi--sEA5f5j8mBpQnZP7vou-fjm9fnx2-r0w8m746PTyjJVQ2UdMtkJXqPktlZWKtZz23SSt5w1WApBqkZ0bWe4EJL3VjDZolmCRd66epfsbb1Tip9nly_14PPNz2Z0cc6aiZaB5KiwoM__QVdxTmO5TjOJNUNUkhdqf0vZFHNObqmn5AeTNhpB30SkS0T6NqLCPrszzt3g-r_kn0wKcLgFvvjgNv836fdnn7bK37Mnm3M</recordid><startdate>202211</startdate><enddate>202211</enddate><creator>Silva Malta, Maria Clara Fernandes</creator><creator>Silva, Sônia Mara Nunes</creator><creator>Oliveira, Milena Batista</creator><creator>Ribeiro, Maisa Aparecida</creator><creator>Martins, Marina Lobato</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2506-8450</orcidid></search><sort><creationdate>202211</creationdate><title>Decline in human T‐cell lymphotropic virus seroprevalence in blood donors from Minas Gerais, Brazil over a 12‐year period (2006–2017)</title><author>Silva Malta, Maria Clara Fernandes ; Silva, Sônia Mara Nunes ; Oliveira, Milena Batista ; Ribeiro, Maisa Aparecida ; Martins, Marina Lobato</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2830-ce127b643174c38c782d4c5b7494251251107856b9ba46674dc62791af0c149e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Algorithms</topic><topic>Blood</topic><topic>Blood & organ donations</topic><topic>Blood Donors</topic><topic>Blood transfusion</topic><topic>Brazil - epidemiology</topic><topic>Brazilian</topic><topic>Chemiluminescence</topic><topic>Female</topic><topic>Health risks</topic><topic>HTLV</topic><topic>HTLV-I Infections - epidemiology</topic><topic>HTLV-II Infections - epidemiology</topic><topic>Human T-lymphotropic virus 1</topic><topic>Human T-lymphotropic virus 2</topic><topic>Humans</topic><topic>Male</topic><topic>Retrospective Studies</topic><topic>Seroepidemiologic Studies</topic><topic>Serology</topic><topic>seroprevalence</topic><topic>T-Lymphocytes</topic><topic>Transfusion</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silva Malta, Maria Clara Fernandes</creatorcontrib><creatorcontrib>Silva, Sônia Mara Nunes</creatorcontrib><creatorcontrib>Oliveira, Milena Batista</creatorcontrib><creatorcontrib>Ribeiro, Maisa Aparecida</creatorcontrib><creatorcontrib>Martins, Marina Lobato</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silva Malta, Maria Clara Fernandes</au><au>Silva, Sônia Mara Nunes</au><au>Oliveira, Milena Batista</au><au>Ribeiro, Maisa Aparecida</au><au>Martins, Marina Lobato</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decline in human T‐cell lymphotropic virus seroprevalence in blood donors from Minas Gerais, Brazil over a 12‐year period (2006–2017)</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J Med Virol</addtitle><date>2022-11</date><risdate>2022</risdate><volume>94</volume><issue>11</issue><spage>5535</spage><epage>5542</epage><pages>5535-5542</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>To investigate a 12‐year historical series (2006–2017) of human T‐cell lymphotropic virus (HTLV)‐positive blood donations from Fundação Hemominas, Minas Gerais, Brazil, an observational retrospective study was performed to evaluate data of blood donor candidates who were screened for HTLV‐1/2 by enzyme‐linked immunosorbent assay or chemiluminescence assays and confirmed by Western blot. We analyzed 3 309 716 blood donations covering 2006–2017 that were extracted from the institutional database. In a total of 3 308 738 donations that have complete algorithm tests, the global frequency of HTLV‐positive donations was 0.012%. The seroprevalence in first‐time blood donors was 28.82/100 000 donors; 0.95/100 000 donations were HTLV‐positive in repeat blood donors. The frequency of HTLV‐seropositive females was significantly higher than males (odds ratio = 1.85, p < 0.001) in first‐time donors. The median age of HTLV‐positive first‐time and repeat donors was similar (36 and 32 years, respectively). First‐time donors ≥41 years had higher odds to be infected. There was a clear tendency of decline in the HTLV‐positive donations in the period analyzed, going from 19.26/100 000 donations to 8.50/100 000 donations. The increase in the proportion of repeat donors over the period analyzed (from 23% in 2006 to 67% in 2017) must be the principal factor that contributed to this drop. Our results showed a continuous decline in the frequency of HTLV‐positive donations from Minas Gerais, Brazil throughout 12 years and emphasize the importance of having a high rate of repeat donors in blood centers to reduce the residual risk of transfusion‐transmitted infections.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35855523</pmid><doi>10.1002/jmv.28010</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2506-8450</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0146-6615 |
| ispartof | Journal of medical virology, 2022-11, Vol.94 (11), p.5535-5542 |
| issn | 0146-6615 1096-9071 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2692074181 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Algorithms Blood Blood & organ donations Blood Donors Blood transfusion Brazil - epidemiology Brazilian Chemiluminescence Female Health risks HTLV HTLV-I Infections - epidemiology HTLV-II Infections - epidemiology Human T-lymphotropic virus 1 Human T-lymphotropic virus 2 Humans Male Retrospective Studies Seroepidemiologic Studies Serology seroprevalence T-Lymphocytes Transfusion Virology Viruses |
| title | Decline in human T‐cell lymphotropic virus seroprevalence in blood donors from Minas Gerais, Brazil over a 12‐year period (2006–2017) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T03%3A19%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Decline%20in%20human%20T%E2%80%90cell%20lymphotropic%20virus%20seroprevalence%20in%20blood%20donors%20from%20Minas%20Gerais,%20Brazil%20over%20a%C2%A012%E2%80%90year%20period%20(2006%E2%80%932017)&rft.jtitle=Journal%20of%20medical%20virology&rft.au=Silva%20Malta,%20Maria%20Clara%C2%A0Fernandes&rft.date=2022-11&rft.volume=94&rft.issue=11&rft.spage=5535&rft.epage=5542&rft.pages=5535-5542&rft.issn=0146-6615&rft.eissn=1096-9071&rft_id=info:doi/10.1002/jmv.28010&rft_dat=%3Cproquest_cross%3E2692074181%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2713211874&rft_id=info:pmid/35855523&rfr_iscdi=true |