Objective Physical Activity Accumulation and Brain Volume in Older Adults: An MRI and Whole-Brain Volume Study
Abstract A decrease in brain volume (ie, brain atrophy) is a marker of cognitive health in older adults. Insufficient weekly accumulation of moderate and vigorous physical activity (MVPA) has been associated with lower brain volume. As this association has been established for a small number of brai...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2023-06, Vol.78 (6), p.902-910 |
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| creator | Melo Neves, Lucas Ritti-Dias, Raphael Juday, Valeria Marquesini, Raquel Mendes Gerage, Aline Cândido Laurentino, Gilberto Hoffmann Nunes, Renato Stubbs, Brendon Ugrinowitsch, Carlos |
| description | Abstract
A decrease in brain volume (ie, brain atrophy) is a marker of cognitive health in older adults. Insufficient weekly accumulation of moderate and vigorous physical activity (MVPA) has been associated with lower brain volume. As this association has been established for a small number of brain areas and structures and atrophy rates seem to be nonuniform between them, more comprehensive analyses are warranted. We compared the volume of 71 brain areas and structures in 45 older adults who met and did not meet objectively measured MVPA recommendations. In addition, we used multiple regression models to determine whether cardiorespiratory fitness (VO2PEAK), MVPA, and health-related risk factors could affect the atrophy of brain areas and structures. An accelerometer (GT9-X ActiGraph) was worn for 7 days. Participants were then classified into 2 groups: |
| doi_str_mv | 10.1093/gerona/glac150 |
| format | Article |
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A decrease in brain volume (ie, brain atrophy) is a marker of cognitive health in older adults. Insufficient weekly accumulation of moderate and vigorous physical activity (MVPA) has been associated with lower brain volume. As this association has been established for a small number of brain areas and structures and atrophy rates seem to be nonuniform between them, more comprehensive analyses are warranted. We compared the volume of 71 brain areas and structures in 45 older adults who met and did not meet objectively measured MVPA recommendations. In addition, we used multiple regression models to determine whether cardiorespiratory fitness (VO2PEAK), MVPA, and health-related risk factors could affect the atrophy of brain areas and structures. An accelerometer (GT9-X ActiGraph) was worn for 7 days. Participants were then classified into 2 groups: <150 minutes MVPA (<150′MVPA; n = 20) and ≥150 minutes MVPA (≥150′MVPA; n = 25) per week. Older adults who accumulated ≥150′MVPA per week had significantly higher absolute and relative (% of intracranial volume) volumes of 39 and 9 brain areas and structures, respectively, than those who accumulated <150′MVPA per week. Higher VO2PEAK seems to be a key predictor of the atrophy of brain areas and structures. In conclusion, meeting weekly physical activity recommendations seems to have a widespread effect on preserving the volume of more than 30 brain areas and structures in older adults. VO2PEAK seems to be the most frequent and important predictor of brain volume preservation.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/glac150</identifier><identifier>PMID: 35857361</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Accelerometry ; Aged ; Atrophy ; Brain ; Brain - diagnostic imaging ; Brain - pathology ; Cardiorespiratory fitness ; Cognitive ability ; Exercise ; Humans ; Magnetic Resonance Imaging ; Neurology ; Older people ; Physical activity ; Regression analysis ; Risk factors</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2023-06, Vol.78 (6), p.902-910</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2022</rights><rights>The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>Copyright Oxford University Press Jun 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-b8b641041aa2159131a52c795f9479fd2c9867d25cc5c8fcc537b322ab13492b3</citedby><cites>FETCH-LOGICAL-c357t-b8b641041aa2159131a52c795f9479fd2c9867d25cc5c8fcc537b322ab13492b3</cites><orcidid>0000-0001-7883-6746 ; 0000-0003-4225-7376 ; 0000-0002-0555-5422 ; 0000-0002-1120-4389 ; 0000-0003-2426-9736 ; 0000-0002-2483-964X ; 0000-0001-8547-419X ; 0000-0001-7364-1050 ; 0000-0001-7387-3791</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35857361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Melo Neves, Lucas</creatorcontrib><creatorcontrib>Ritti-Dias, Raphael</creatorcontrib><creatorcontrib>Juday, Valeria</creatorcontrib><creatorcontrib>Marquesini, Raquel</creatorcontrib><creatorcontrib>Mendes Gerage, Aline</creatorcontrib><creatorcontrib>Cândido Laurentino, Gilberto</creatorcontrib><creatorcontrib>Hoffmann Nunes, Renato</creatorcontrib><creatorcontrib>Stubbs, Brendon</creatorcontrib><creatorcontrib>Ugrinowitsch, Carlos</creatorcontrib><title>Objective Physical Activity Accumulation and Brain Volume in Older Adults: An MRI and Whole-Brain Volume Study</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Abstract
A decrease in brain volume (ie, brain atrophy) is a marker of cognitive health in older adults. Insufficient weekly accumulation of moderate and vigorous physical activity (MVPA) has been associated with lower brain volume. As this association has been established for a small number of brain areas and structures and atrophy rates seem to be nonuniform between them, more comprehensive analyses are warranted. We compared the volume of 71 brain areas and structures in 45 older adults who met and did not meet objectively measured MVPA recommendations. In addition, we used multiple regression models to determine whether cardiorespiratory fitness (VO2PEAK), MVPA, and health-related risk factors could affect the atrophy of brain areas and structures. An accelerometer (GT9-X ActiGraph) was worn for 7 days. Participants were then classified into 2 groups: <150 minutes MVPA (<150′MVPA; n = 20) and ≥150 minutes MVPA (≥150′MVPA; n = 25) per week. Older adults who accumulated ≥150′MVPA per week had significantly higher absolute and relative (% of intracranial volume) volumes of 39 and 9 brain areas and structures, respectively, than those who accumulated <150′MVPA per week. Higher VO2PEAK seems to be a key predictor of the atrophy of brain areas and structures. In conclusion, meeting weekly physical activity recommendations seems to have a widespread effect on preserving the volume of more than 30 brain areas and structures in older adults. VO2PEAK seems to be the most frequent and important predictor of brain volume preservation.</description><subject>Accelerometry</subject><subject>Aged</subject><subject>Atrophy</subject><subject>Brain</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - pathology</subject><subject>Cardiorespiratory fitness</subject><subject>Cognitive ability</subject><subject>Exercise</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Neurology</subject><subject>Older people</subject><subject>Physical activity</subject><subject>Regression analysis</subject><subject>Risk factors</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLxDAUhYMojq-tSwm40UVn8miaxt0oPgaUEd-7kqapdkibMWmE-fd27CjoxixuzoXvHi73ALCP0RAjQUev2tlGjl6NVJihNbCFOUsjRtnLeqcRFxFDKBmAbe9naPkY2QQDylLGaYK3QDPNZ1q11YeGt28LXylp4HjZV-2iEyrUwci2sg2UTQFPnawa-GRNqDXs1NQU2sFxEUzrT-C4gTd3ky_w-c0aHf3C79tQLHbBRimN13urfwc8Xpw_nF1F19PLydn4OlKU8TbK0zyJMYqxlAQzgSmWjCguWCliLsqCKJEmvCBMKabSsquU55QQmWMaC5LTHXDU-86dfQ_at1ldeaWNkY22wWckEQRxihLcoYd_0JkNrum2y0hKKGY85Utq2FPKWe-dLrO5q2rpFhlG2TKJrE8iWyXRDRysbENe6-IH_z59Bxz3gA3z_8w-AfbCkyc</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Melo Neves, Lucas</creator><creator>Ritti-Dias, Raphael</creator><creator>Juday, Valeria</creator><creator>Marquesini, Raquel</creator><creator>Mendes Gerage, Aline</creator><creator>Cândido Laurentino, Gilberto</creator><creator>Hoffmann Nunes, Renato</creator><creator>Stubbs, Brendon</creator><creator>Ugrinowitsch, Carlos</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7883-6746</orcidid><orcidid>https://orcid.org/0000-0003-4225-7376</orcidid><orcidid>https://orcid.org/0000-0002-0555-5422</orcidid><orcidid>https://orcid.org/0000-0002-1120-4389</orcidid><orcidid>https://orcid.org/0000-0003-2426-9736</orcidid><orcidid>https://orcid.org/0000-0002-2483-964X</orcidid><orcidid>https://orcid.org/0000-0001-8547-419X</orcidid><orcidid>https://orcid.org/0000-0001-7364-1050</orcidid><orcidid>https://orcid.org/0000-0001-7387-3791</orcidid></search><sort><creationdate>20230601</creationdate><title>Objective Physical Activity Accumulation and Brain Volume in Older Adults: An MRI and Whole-Brain Volume Study</title><author>Melo Neves, Lucas ; Ritti-Dias, Raphael ; Juday, Valeria ; Marquesini, Raquel ; Mendes Gerage, Aline ; Cândido Laurentino, Gilberto ; Hoffmann Nunes, Renato ; Stubbs, Brendon ; Ugrinowitsch, Carlos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-b8b641041aa2159131a52c795f9479fd2c9867d25cc5c8fcc537b322ab13492b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Accelerometry</topic><topic>Aged</topic><topic>Atrophy</topic><topic>Brain</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - pathology</topic><topic>Cardiorespiratory fitness</topic><topic>Cognitive ability</topic><topic>Exercise</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Neurology</topic><topic>Older people</topic><topic>Physical activity</topic><topic>Regression analysis</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Melo Neves, Lucas</creatorcontrib><creatorcontrib>Ritti-Dias, Raphael</creatorcontrib><creatorcontrib>Juday, Valeria</creatorcontrib><creatorcontrib>Marquesini, Raquel</creatorcontrib><creatorcontrib>Mendes Gerage, Aline</creatorcontrib><creatorcontrib>Cândido Laurentino, Gilberto</creatorcontrib><creatorcontrib>Hoffmann Nunes, Renato</creatorcontrib><creatorcontrib>Stubbs, Brendon</creatorcontrib><creatorcontrib>Ugrinowitsch, Carlos</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The journals of gerontology. 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A decrease in brain volume (ie, brain atrophy) is a marker of cognitive health in older adults. Insufficient weekly accumulation of moderate and vigorous physical activity (MVPA) has been associated with lower brain volume. As this association has been established for a small number of brain areas and structures and atrophy rates seem to be nonuniform between them, more comprehensive analyses are warranted. We compared the volume of 71 brain areas and structures in 45 older adults who met and did not meet objectively measured MVPA recommendations. In addition, we used multiple regression models to determine whether cardiorespiratory fitness (VO2PEAK), MVPA, and health-related risk factors could affect the atrophy of brain areas and structures. An accelerometer (GT9-X ActiGraph) was worn for 7 days. Participants were then classified into 2 groups: <150 minutes MVPA (<150′MVPA; n = 20) and ≥150 minutes MVPA (≥150′MVPA; n = 25) per week. Older adults who accumulated ≥150′MVPA per week had significantly higher absolute and relative (% of intracranial volume) volumes of 39 and 9 brain areas and structures, respectively, than those who accumulated <150′MVPA per week. Higher VO2PEAK seems to be a key predictor of the atrophy of brain areas and structures. In conclusion, meeting weekly physical activity recommendations seems to have a widespread effect on preserving the volume of more than 30 brain areas and structures in older adults. VO2PEAK seems to be the most frequent and important predictor of brain volume preservation.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>35857361</pmid><doi>10.1093/gerona/glac150</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7883-6746</orcidid><orcidid>https://orcid.org/0000-0003-4225-7376</orcidid><orcidid>https://orcid.org/0000-0002-0555-5422</orcidid><orcidid>https://orcid.org/0000-0002-1120-4389</orcidid><orcidid>https://orcid.org/0000-0003-2426-9736</orcidid><orcidid>https://orcid.org/0000-0002-2483-964X</orcidid><orcidid>https://orcid.org/0000-0001-8547-419X</orcidid><orcidid>https://orcid.org/0000-0001-7364-1050</orcidid><orcidid>https://orcid.org/0000-0001-7387-3791</orcidid></addata></record> |
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| ispartof | The journals of gerontology. Series A, Biological sciences and medical sciences, 2023-06, Vol.78 (6), p.902-910 |
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| subjects | Accelerometry Aged Atrophy Brain Brain - diagnostic imaging Brain - pathology Cardiorespiratory fitness Cognitive ability Exercise Humans Magnetic Resonance Imaging Neurology Older people Physical activity Regression analysis Risk factors |
| title | Objective Physical Activity Accumulation and Brain Volume in Older Adults: An MRI and Whole-Brain Volume Study |
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