Antileukemic effects of topoisomerase I inhibitors mediated by de-SUMOylase SENP1

SUMO-specific proteases (SENPs) play pivotal roles in maintaining the balance of SUMOylation/de-SUMOylation and in SUMO recycling. Deregulation of SENPs leads to cellular dysfunction and corresponding diseases. As a key member of the SENP family, SENP1 is highly correlated with various cancers. Howe...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2022-12, Vol.1868 (12), p.166492-166492, Article 166492
Hauptverfasser:	Niu, Qun, Hou, Wanxin, Yan, Yinjie, Sun, Shuzhang, Lin, Yanyan, Fang, Houshun, Ma, Chunshuang, Dong, Changsheng, Cheng, Yixuan, Xu, Yan, Ding, Ming, Wang, Shuxuan, Cui, Zhiyan, Chen, Yao, Li, Hegen, Li, Hui, Xiao, Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	7-ethylcamptothecin Acute lymphoblastic leukemia SENP1 TOP1 Topotecan
Online-Zugang:	Volltext
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