Inactivation Mechanism of the Fatty Acid Amide Hydrolase Inhibitor BIA 10‐2474

BIA 10‐2474 is a time‐dependent inhibitor of fatty acid amide hydrolase (FAAH) that was under clinical development for the treatment of neurological conditions when the program was terminated after one subject died and four were hospitalized with neurological symptoms during a first‐in‐human clinica...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2022-10, Vol.23 (20), p.e202200166-n/a
Hauptverfasser:	Cerqueira, Nuno M. F. S. A., Neves, Marco, Rocha, Juliana, Soares‐da Silva, Patrício, Palma, P. Nuno
Format:	Artikel
Sprache:	eng
Schlagworte:	Deactivation Enzymes Fatty acids Fatty-acid amide hydrolase Free energy Hydrogen bonds Hydrolase Imidazole Inactivation Inhibitors Molecular modelling Nucleophiles Quantum mechanics
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