Ex Vivo Liver Machine Perfusion: Comprehensive Review of Common Animal Models
The most common preservation technique for liver grafts is static cold storage. Due to the organ shortage for liver transplantation (LT), extended criteria donor (ECD) allografts are increasingly used—despite the higher risk of inferior outcome after transplantation. Ex vivo liver machine perfusion...
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| Veröffentlicht in: | Tissue engineering. Part B, Reviews Reviews, 2023-02, Vol.29 (1), p.1-27 |
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| creator | Muth, Vanessa Gassner, Joseph M G V Moosburner, Simon Lurje, Georg Michelotto, Julian Strobl, Felix Knaub, Kristina Engelmann, Cornelius Tacke, Frank Selzner, Markus Pratschke, Johann Sauer, Igor M Raschzok, Nathanael |
| description | The most common preservation technique for liver grafts is static cold storage. Due to the organ shortage for liver transplantation (LT), extended criteria donor (ECD) allografts are increasingly used—despite the higher risk of inferior outcome after transplantation.
Ex vivo
liver machine perfusion (MP) has been developed to improve the outcome of transplantation, especially with ECD grafts, and is currently under evaluation in clinical trials. We performed a literature search on
PubMed
and
ISI Web of Science
to assemble an overview of rodent and porcine animal models of
ex vivo
liver MP for transplantation, which is essential for the present and future development of clinical liver MP. Hypothermic, subnormothermic, and normothermic MP systems have been successfully used for rat and pig LT. In comparison with hypothermic systems, normothermic perfusion often incorporates a dialysis unit. Moreover, it enables metabolic assessment of liver grafts. Allografts experiencing warm ischemic time have a superior survival rate after MP compared with cold storage alone, irrespective of the temperature used for perfusion. Furthermore,
ex vivo
MP improves the outcome of regular and ECD liver grafts in animal models. Small and large animal models of
ex vivo
liver MP are available to foster the further development of this new technology. |
| doi_str_mv | 10.1089/ten.teb.2022.0018 |
| format | Article |
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Ex vivo
liver machine perfusion (MP) has been developed to improve the outcome of transplantation, especially with ECD grafts, and is currently under evaluation in clinical trials. We performed a literature search on
PubMed
and
ISI Web of Science
to assemble an overview of rodent and porcine animal models of
ex vivo
liver MP for transplantation, which is essential for the present and future development of clinical liver MP. Hypothermic, subnormothermic, and normothermic MP systems have been successfully used for rat and pig LT. In comparison with hypothermic systems, normothermic perfusion often incorporates a dialysis unit. Moreover, it enables metabolic assessment of liver grafts. Allografts experiencing warm ischemic time have a superior survival rate after MP compared with cold storage alone, irrespective of the temperature used for perfusion. Furthermore,
ex vivo
MP improves the outcome of regular and ECD liver grafts in animal models. Small and large animal models of
ex vivo
liver MP are available to foster the further development of this new technology.</description><identifier>ISSN: 1937-3368</identifier><identifier>EISSN: 1937-3376</identifier><identifier>DOI: 10.1089/ten.teb.2022.0018</identifier><identifier>PMID: 35848526</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc., publishers</publisher><subject>Allografts ; Animal models ; Animals ; Clinical trials ; Cold storage ; Cryopreservation ; Dialysis ; Ischemia ; Liver ; Liver transplantation ; Liver Transplantation - methods ; Liver transplants ; Models, Animal ; Organ Preservation - methods ; Perfusion ; Perfusion - methods ; Quality control ; Rats ; Review Articles ; Swine ; Therapeutic applications</subject><ispartof>Tissue engineering. Part B, Reviews, 2023-02, Vol.29 (1), p.1-27</ispartof><rights>2023, Mary Ann Liebert, Inc., publishers</rights><rights>Copyright Mary Ann Liebert, Inc. Feb 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-eab5584d708ed938d196cd6bb25a5c137508a935912095e6ce7921a99b240093</citedby><cites>FETCH-LOGICAL-c377t-eab5584d708ed938d196cd6bb25a5c137508a935912095e6ce7921a99b240093</cites><orcidid>0000-0001-9674-0756 ; 0000-0002-6984-2738</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35848526$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muth, Vanessa</creatorcontrib><creatorcontrib>Gassner, Joseph M G V</creatorcontrib><creatorcontrib>Moosburner, Simon</creatorcontrib><creatorcontrib>Lurje, Georg</creatorcontrib><creatorcontrib>Michelotto, Julian</creatorcontrib><creatorcontrib>Strobl, Felix</creatorcontrib><creatorcontrib>Knaub, Kristina</creatorcontrib><creatorcontrib>Engelmann, Cornelius</creatorcontrib><creatorcontrib>Tacke, Frank</creatorcontrib><creatorcontrib>Selzner, Markus</creatorcontrib><creatorcontrib>Pratschke, Johann</creatorcontrib><creatorcontrib>Sauer, Igor M</creatorcontrib><creatorcontrib>Raschzok, Nathanael</creatorcontrib><title>Ex Vivo Liver Machine Perfusion: Comprehensive Review of Common Animal Models</title><title>Tissue engineering. Part B, Reviews</title><addtitle>Tissue Eng Part B Rev</addtitle><description>The most common preservation technique for liver grafts is static cold storage. Due to the organ shortage for liver transplantation (LT), extended criteria donor (ECD) allografts are increasingly used—despite the higher risk of inferior outcome after transplantation.
Ex vivo
liver machine perfusion (MP) has been developed to improve the outcome of transplantation, especially with ECD grafts, and is currently under evaluation in clinical trials. We performed a literature search on
PubMed
and
ISI Web of Science
to assemble an overview of rodent and porcine animal models of
ex vivo
liver MP for transplantation, which is essential for the present and future development of clinical liver MP. Hypothermic, subnormothermic, and normothermic MP systems have been successfully used for rat and pig LT. In comparison with hypothermic systems, normothermic perfusion often incorporates a dialysis unit. Moreover, it enables metabolic assessment of liver grafts. Allografts experiencing warm ischemic time have a superior survival rate after MP compared with cold storage alone, irrespective of the temperature used for perfusion. Furthermore,
ex vivo
MP improves the outcome of regular and ECD liver grafts in animal models. Small and large animal models of
ex vivo
liver MP are available to foster the further development of this new technology.</description><subject>Allografts</subject><subject>Animal models</subject><subject>Animals</subject><subject>Clinical trials</subject><subject>Cold storage</subject><subject>Cryopreservation</subject><subject>Dialysis</subject><subject>Ischemia</subject><subject>Liver</subject><subject>Liver transplantation</subject><subject>Liver Transplantation - methods</subject><subject>Liver transplants</subject><subject>Models, Animal</subject><subject>Organ Preservation - methods</subject><subject>Perfusion</subject><subject>Perfusion - methods</subject><subject>Quality control</subject><subject>Rats</subject><subject>Review Articles</subject><subject>Swine</subject><subject>Therapeutic applications</subject><issn>1937-3368</issn><issn>1937-3376</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtLAzEQx4Movj-AFwl48dKax24e3qTUB7QoUryG7O4UV3aTmuxW_fZmafXgyUOYMPzmz8wPoTNKxpQofdWBG3dQjBlhbEwIVTvokGouR5xLsfv7F-oAHcX4RoggQqp9dMBzlamciUM0n37il3rt8axeQ8BzW77WDvAThGUfa--u8cS3qwCv4GIi8DOsa_jAfjn0W-_wjatb2-C5r6CJJ2hvaZsIp9t6jBa308XkfjR7vHuY3MxGJZeyG4Et8rRBJYmCSnNVUS3KShQFy21eUi5zoqzmuaaM6BxECVIzarUuWEaI5sfochO7Cv69h9iZto4lNI114PtomNA0EzTdm9CLP-ib74NLyxkmZTZwKksU3VBl8DEGWJpVSGeFL0OJGVSbpDq9wgyqzaA6zZxvk_uihep34sdtAuQGGNrWuaaGAkL3j-hvqSuL7w</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Muth, Vanessa</creator><creator>Gassner, Joseph M G V</creator><creator>Moosburner, Simon</creator><creator>Lurje, Georg</creator><creator>Michelotto, Julian</creator><creator>Strobl, Felix</creator><creator>Knaub, Kristina</creator><creator>Engelmann, Cornelius</creator><creator>Tacke, Frank</creator><creator>Selzner, Markus</creator><creator>Pratschke, Johann</creator><creator>Sauer, Igor M</creator><creator>Raschzok, Nathanael</creator><general>Mary Ann Liebert, Inc., publishers</general><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9674-0756</orcidid><orcidid>https://orcid.org/0000-0002-6984-2738</orcidid></search><sort><creationdate>20230201</creationdate><title>Ex Vivo Liver Machine Perfusion: Comprehensive Review of Common Animal Models</title><author>Muth, Vanessa ; Gassner, Joseph M G V ; Moosburner, Simon ; Lurje, Georg ; Michelotto, Julian ; Strobl, Felix ; Knaub, Kristina ; Engelmann, Cornelius ; Tacke, Frank ; Selzner, Markus ; Pratschke, Johann ; Sauer, Igor M ; Raschzok, Nathanael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-eab5584d708ed938d196cd6bb25a5c137508a935912095e6ce7921a99b240093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Allografts</topic><topic>Animal models</topic><topic>Animals</topic><topic>Clinical trials</topic><topic>Cold storage</topic><topic>Cryopreservation</topic><topic>Dialysis</topic><topic>Ischemia</topic><topic>Liver</topic><topic>Liver transplantation</topic><topic>Liver Transplantation - methods</topic><topic>Liver transplants</topic><topic>Models, Animal</topic><topic>Organ Preservation - methods</topic><topic>Perfusion</topic><topic>Perfusion - methods</topic><topic>Quality control</topic><topic>Rats</topic><topic>Review Articles</topic><topic>Swine</topic><topic>Therapeutic applications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muth, Vanessa</creatorcontrib><creatorcontrib>Gassner, Joseph M G V</creatorcontrib><creatorcontrib>Moosburner, Simon</creatorcontrib><creatorcontrib>Lurje, Georg</creatorcontrib><creatorcontrib>Michelotto, Julian</creatorcontrib><creatorcontrib>Strobl, Felix</creatorcontrib><creatorcontrib>Knaub, Kristina</creatorcontrib><creatorcontrib>Engelmann, Cornelius</creatorcontrib><creatorcontrib>Tacke, Frank</creatorcontrib><creatorcontrib>Selzner, Markus</creatorcontrib><creatorcontrib>Pratschke, Johann</creatorcontrib><creatorcontrib>Sauer, Igor M</creatorcontrib><creatorcontrib>Raschzok, Nathanael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Tissue engineering. Part B, Reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muth, Vanessa</au><au>Gassner, Joseph M G V</au><au>Moosburner, Simon</au><au>Lurje, Georg</au><au>Michelotto, Julian</au><au>Strobl, Felix</au><au>Knaub, Kristina</au><au>Engelmann, Cornelius</au><au>Tacke, Frank</au><au>Selzner, Markus</au><au>Pratschke, Johann</au><au>Sauer, Igor M</au><au>Raschzok, Nathanael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ex Vivo Liver Machine Perfusion: Comprehensive Review of Common Animal Models</atitle><jtitle>Tissue engineering. Part B, Reviews</jtitle><addtitle>Tissue Eng Part B Rev</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>29</volume><issue>1</issue><spage>1</spage><epage>27</epage><pages>1-27</pages><issn>1937-3368</issn><eissn>1937-3376</eissn><abstract>The most common preservation technique for liver grafts is static cold storage. Due to the organ shortage for liver transplantation (LT), extended criteria donor (ECD) allografts are increasingly used—despite the higher risk of inferior outcome after transplantation.
Ex vivo
liver machine perfusion (MP) has been developed to improve the outcome of transplantation, especially with ECD grafts, and is currently under evaluation in clinical trials. We performed a literature search on
PubMed
and
ISI Web of Science
to assemble an overview of rodent and porcine animal models of
ex vivo
liver MP for transplantation, which is essential for the present and future development of clinical liver MP. Hypothermic, subnormothermic, and normothermic MP systems have been successfully used for rat and pig LT. In comparison with hypothermic systems, normothermic perfusion often incorporates a dialysis unit. Moreover, it enables metabolic assessment of liver grafts. Allografts experiencing warm ischemic time have a superior survival rate after MP compared with cold storage alone, irrespective of the temperature used for perfusion. Furthermore,
ex vivo
MP improves the outcome of regular and ECD liver grafts in animal models. Small and large animal models of
ex vivo
liver MP are available to foster the further development of this new technology.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc., publishers</pub><pmid>35848526</pmid><doi>10.1089/ten.teb.2022.0018</doi><tpages>27</tpages><orcidid>https://orcid.org/0000-0001-9674-0756</orcidid><orcidid>https://orcid.org/0000-0002-6984-2738</orcidid></addata></record> |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Allografts Animal models Animals Clinical trials Cold storage Cryopreservation Dialysis Ischemia Liver Liver transplantation Liver Transplantation - methods Liver transplants Models, Animal Organ Preservation - methods Perfusion Perfusion - methods Quality control Rats Review Articles Swine Therapeutic applications |
| title | Ex Vivo Liver Machine Perfusion: Comprehensive Review of Common Animal Models |
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