DNA methyltransferase-1 in acute myeloid leukaemia: beyond the maintenance of DNA methylation

DNA methylation is considered an essential epigenetic event during leukaemogenesis and the emergence of drug resistance, which is primarily regulated by DNA methyltransferases. DNA methyltransferase-1 (DNMT1) is one of the members of DNA methyltransferases, in charge of maintaining established methy...

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Veröffentlicht in:	Annals of medicine (Helsinki) 2022-12, Vol.54 (1), p.2011-2023
Hauptverfasser:	Li, Mengyuan, Zhang, Donghua
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukaemia DNA DNA (Cytosine-5-)-Methyltransferase 1 - genetics DNA Methylation DNA methyltransferase-1 drug resistance epigenetics Hematology Humans Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Review targeted therapy
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