The role of lipid profile in the relationship between particulate matters and hyperuricemia: A prospective population study
Recent studies in specific population subgroups (e.g., pregnant women) have suggested PM exposure increases the risk of hyperuricemia. However, no studies have examined this in the general population. Furthermore, the underlying mechanism through which PM impacts hyperuricemia risk is poorly underst...
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| Veröffentlicht in: | Environmental research 2022-11, Vol.214, p.113865-113865, Article 113865 |
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| creator | Zeng, Chunmei Guo, Bing Wan, Yang Guo, Yuming Chen, Gongbo Duoji, Zhuoma Qian, Wen Danzhen, Wangjiu Meng, Qiong Chen, Liling Wu, Kunpeng Wang, Xing Feng, Shiyu Jiang, Min Xiong, Hai Zhao, Xing |
| description | Recent studies in specific population subgroups (e.g., pregnant women) have suggested PM exposure increases the risk of hyperuricemia. However, no studies have examined this in the general population. Furthermore, the underlying mechanism through which PM impacts hyperuricemia risk is poorly understood.
To assess the association between long-term exposure to PM and risk of hyperuricemia and whether this association is mediated by lipid profile.
We included 5939 participants in Southwest China from the China Multi-Ethnic Cohort (baseline 2018–2019, follow-up 2020–2021). Long-term PM pollutants (PM1, PM2.5, PM10) exposure for each individual was represented by the three-year average PM levels before the baseline survey. Hyperuricemia at follow-up was defined as the serum uric acid above 7.0 mg/dL in men and 6.0 mg/dL in women. Serum lipids were measured at baseline including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). The association of PM with hyperuricemia was accessed through logistic regression. The potential mediation effects of serum lipids were evaluated through causal mediation analyses.
A total of 837 participants were newly diagnosed with hyperuricemia. The odds ratios of hyperuricemia associated with an interquartile range (IQR) increase in PM1, PM2.5, and PM10 (IQR: 21.10, 25.78, 30.43 μg m−3) were 1.72 (95% CI: 1.23, 2.39), 2.68 (95% CI: 1.59, 4.49), and 1.81 (95% CI: 1.20, 2.72), respectively. The association between PM2.5, PM1, and PM10 on hyperuricemia was mediated by HDL-C (10%) and LDL-C (3%).
Higher particulate matter exposure was associated with higher hyperuricemia incidence. The decline in HDL-C and rise in LDL-C partially mediated this association. These findings were conducive to scientific research about the underlying mechanism of PM on hyperuricemia.
•Assessed the relation of PM exposure to hyperuricemia among the general population.•PM exposure increased the risk of hyperuricemia and alter the serum lipid profile.•High/Low-density lipoprotein cholesterol mediated the association of PM on HUA. |
| doi_str_mv | 10.1016/j.envres.2022.113865 |
| format | Article |
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To assess the association between long-term exposure to PM and risk of hyperuricemia and whether this association is mediated by lipid profile.
We included 5939 participants in Southwest China from the China Multi-Ethnic Cohort (baseline 2018–2019, follow-up 2020–2021). Long-term PM pollutants (PM1, PM2.5, PM10) exposure for each individual was represented by the three-year average PM levels before the baseline survey. Hyperuricemia at follow-up was defined as the serum uric acid above 7.0 mg/dL in men and 6.0 mg/dL in women. Serum lipids were measured at baseline including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). The association of PM with hyperuricemia was accessed through logistic regression. The potential mediation effects of serum lipids were evaluated through causal mediation analyses.
A total of 837 participants were newly diagnosed with hyperuricemia. The odds ratios of hyperuricemia associated with an interquartile range (IQR) increase in PM1, PM2.5, and PM10 (IQR: 21.10, 25.78, 30.43 μg m−3) were 1.72 (95% CI: 1.23, 2.39), 2.68 (95% CI: 1.59, 4.49), and 1.81 (95% CI: 1.20, 2.72), respectively. The association between PM2.5, PM1, and PM10 on hyperuricemia was mediated by HDL-C (10%) and LDL-C (3%).
Higher particulate matter exposure was associated with higher hyperuricemia incidence. The decline in HDL-C and rise in LDL-C partially mediated this association. These findings were conducive to scientific research about the underlying mechanism of PM on hyperuricemia.
•Assessed the relation of PM exposure to hyperuricemia among the general population.•PM exposure increased the risk of hyperuricemia and alter the serum lipid profile.•High/Low-density lipoprotein cholesterol mediated the association of PM on HUA.</description><identifier>ISSN: 0013-9351</identifier><identifier>EISSN: 1096-0953</identifier><identifier>DOI: 10.1016/j.envres.2022.113865</identifier><language>eng</language><publisher>Elsevier Inc</publisher><subject>Hyperuricemia ; Lipid profile ; Particulate matter ; Prospective study</subject><ispartof>Environmental research, 2022-11, Vol.214, p.113865-113865, Article 113865</ispartof><rights>2022 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-20104c47bbfdfbbcc97a1fd48e3d73f4abb5f8c1d34dcdbe85fe39ca61e166f93</citedby><cites>FETCH-LOGICAL-c339t-20104c47bbfdfbbcc97a1fd48e3d73f4abb5f8c1d34dcdbe85fe39ca61e166f93</cites><orcidid>0000-0001-5713-3603 ; 0000-0002-2498-9816</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.envres.2022.113865$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids></links><search><creatorcontrib>Zeng, Chunmei</creatorcontrib><creatorcontrib>Guo, Bing</creatorcontrib><creatorcontrib>Wan, Yang</creatorcontrib><creatorcontrib>Guo, Yuming</creatorcontrib><creatorcontrib>Chen, Gongbo</creatorcontrib><creatorcontrib>Duoji, Zhuoma</creatorcontrib><creatorcontrib>Qian, Wen</creatorcontrib><creatorcontrib>Danzhen, Wangjiu</creatorcontrib><creatorcontrib>Meng, Qiong</creatorcontrib><creatorcontrib>Chen, Liling</creatorcontrib><creatorcontrib>Wu, Kunpeng</creatorcontrib><creatorcontrib>Wang, Xing</creatorcontrib><creatorcontrib>Feng, Shiyu</creatorcontrib><creatorcontrib>Jiang, Min</creatorcontrib><creatorcontrib>Xiong, Hai</creatorcontrib><creatorcontrib>Zhao, Xing</creatorcontrib><creatorcontrib>on behalf of the China Muti-Ethnic Cohort (CMEC) collaborative group</creatorcontrib><title>The role of lipid profile in the relationship between particulate matters and hyperuricemia: A prospective population study</title><title>Environmental research</title><description>Recent studies in specific population subgroups (e.g., pregnant women) have suggested PM exposure increases the risk of hyperuricemia. However, no studies have examined this in the general population. Furthermore, the underlying mechanism through which PM impacts hyperuricemia risk is poorly understood.
To assess the association between long-term exposure to PM and risk of hyperuricemia and whether this association is mediated by lipid profile.
We included 5939 participants in Southwest China from the China Multi-Ethnic Cohort (baseline 2018–2019, follow-up 2020–2021). Long-term PM pollutants (PM1, PM2.5, PM10) exposure for each individual was represented by the three-year average PM levels before the baseline survey. Hyperuricemia at follow-up was defined as the serum uric acid above 7.0 mg/dL in men and 6.0 mg/dL in women. Serum lipids were measured at baseline including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). The association of PM with hyperuricemia was accessed through logistic regression. The potential mediation effects of serum lipids were evaluated through causal mediation analyses.
A total of 837 participants were newly diagnosed with hyperuricemia. The odds ratios of hyperuricemia associated with an interquartile range (IQR) increase in PM1, PM2.5, and PM10 (IQR: 21.10, 25.78, 30.43 μg m−3) were 1.72 (95% CI: 1.23, 2.39), 2.68 (95% CI: 1.59, 4.49), and 1.81 (95% CI: 1.20, 2.72), respectively. The association between PM2.5, PM1, and PM10 on hyperuricemia was mediated by HDL-C (10%) and LDL-C (3%).
Higher particulate matter exposure was associated with higher hyperuricemia incidence. The decline in HDL-C and rise in LDL-C partially mediated this association. These findings were conducive to scientific research about the underlying mechanism of PM on hyperuricemia.
•Assessed the relation of PM exposure to hyperuricemia among the general population.•PM exposure increased the risk of hyperuricemia and alter the serum lipid profile.•High/Low-density lipoprotein cholesterol mediated the association of PM on HUA.</description><subject>Hyperuricemia</subject><subject>Lipid profile</subject><subject>Particulate matter</subject><subject>Prospective study</subject><issn>0013-9351</issn><issn>1096-0953</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9UMlqwzAQFaWFpssf9KBjL3Yly3biHgohdINAL-lZaBkRBS-qJKeE_nxl3HNPw8xbePMQuqMkp4TWD4cc-qOHkBekKHJK2aquztCCkqbOSFOxc7QghLKsYRW9RFchHNJKK0YW6Ge3B-yHFvBgcGud1dj5wdh0sD2OEwitiHbow946LCF-A_TYCR-tGhMCuBMxgg9Y9BrvTw786K2CzopHvJ7MggMV7RGwG9w4e-EQR326QRdGtAFu_-Y1-nx53m3esu3H6_tmvc0UY03MCkJJqcqllEYbKZVqloIaXa6A6SUzpZCyMitFNSu10hJWlQHWKFFToHVtGnaN7mffFOZrhBB5Z4OCthU9DGPgRd1QUpWkYIlazlSVcgcPhjtvO-FPnBI-dc0PfO6aT13zueske5plkN44WvA8KAu9Am19ep7rwf5v8AuO044v</recordid><startdate>202211</startdate><enddate>202211</enddate><creator>Zeng, Chunmei</creator><creator>Guo, Bing</creator><creator>Wan, Yang</creator><creator>Guo, Yuming</creator><creator>Chen, Gongbo</creator><creator>Duoji, Zhuoma</creator><creator>Qian, Wen</creator><creator>Danzhen, Wangjiu</creator><creator>Meng, Qiong</creator><creator>Chen, Liling</creator><creator>Wu, Kunpeng</creator><creator>Wang, Xing</creator><creator>Feng, Shiyu</creator><creator>Jiang, Min</creator><creator>Xiong, Hai</creator><creator>Zhao, Xing</creator><general>Elsevier Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5713-3603</orcidid><orcidid>https://orcid.org/0000-0002-2498-9816</orcidid></search><sort><creationdate>202211</creationdate><title>The role of lipid profile in the relationship between particulate matters and hyperuricemia: A prospective population study</title><author>Zeng, Chunmei ; Guo, Bing ; Wan, Yang ; Guo, Yuming ; Chen, Gongbo ; Duoji, Zhuoma ; Qian, Wen ; Danzhen, Wangjiu ; Meng, Qiong ; Chen, Liling ; Wu, Kunpeng ; Wang, Xing ; Feng, Shiyu ; Jiang, Min ; Xiong, Hai ; Zhao, Xing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-20104c47bbfdfbbcc97a1fd48e3d73f4abb5f8c1d34dcdbe85fe39ca61e166f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Hyperuricemia</topic><topic>Lipid profile</topic><topic>Particulate matter</topic><topic>Prospective study</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zeng, Chunmei</creatorcontrib><creatorcontrib>Guo, Bing</creatorcontrib><creatorcontrib>Wan, Yang</creatorcontrib><creatorcontrib>Guo, Yuming</creatorcontrib><creatorcontrib>Chen, Gongbo</creatorcontrib><creatorcontrib>Duoji, Zhuoma</creatorcontrib><creatorcontrib>Qian, Wen</creatorcontrib><creatorcontrib>Danzhen, Wangjiu</creatorcontrib><creatorcontrib>Meng, Qiong</creatorcontrib><creatorcontrib>Chen, Liling</creatorcontrib><creatorcontrib>Wu, Kunpeng</creatorcontrib><creatorcontrib>Wang, Xing</creatorcontrib><creatorcontrib>Feng, Shiyu</creatorcontrib><creatorcontrib>Jiang, Min</creatorcontrib><creatorcontrib>Xiong, Hai</creatorcontrib><creatorcontrib>Zhao, Xing</creatorcontrib><creatorcontrib>on behalf of the China Muti-Ethnic Cohort (CMEC) collaborative group</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeng, Chunmei</au><au>Guo, Bing</au><au>Wan, Yang</au><au>Guo, Yuming</au><au>Chen, Gongbo</au><au>Duoji, Zhuoma</au><au>Qian, Wen</au><au>Danzhen, Wangjiu</au><au>Meng, Qiong</au><au>Chen, Liling</au><au>Wu, Kunpeng</au><au>Wang, Xing</au><au>Feng, Shiyu</au><au>Jiang, Min</au><au>Xiong, Hai</au><au>Zhao, Xing</au><aucorp>on behalf of the China Muti-Ethnic Cohort (CMEC) collaborative group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of lipid profile in the relationship between particulate matters and hyperuricemia: A prospective population study</atitle><jtitle>Environmental research</jtitle><date>2022-11</date><risdate>2022</risdate><volume>214</volume><spage>113865</spage><epage>113865</epage><pages>113865-113865</pages><artnum>113865</artnum><issn>0013-9351</issn><eissn>1096-0953</eissn><abstract>Recent studies in specific population subgroups (e.g., pregnant women) have suggested PM exposure increases the risk of hyperuricemia. However, no studies have examined this in the general population. Furthermore, the underlying mechanism through which PM impacts hyperuricemia risk is poorly understood.
To assess the association between long-term exposure to PM and risk of hyperuricemia and whether this association is mediated by lipid profile.
We included 5939 participants in Southwest China from the China Multi-Ethnic Cohort (baseline 2018–2019, follow-up 2020–2021). Long-term PM pollutants (PM1, PM2.5, PM10) exposure for each individual was represented by the three-year average PM levels before the baseline survey. Hyperuricemia at follow-up was defined as the serum uric acid above 7.0 mg/dL in men and 6.0 mg/dL in women. Serum lipids were measured at baseline including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). The association of PM with hyperuricemia was accessed through logistic regression. The potential mediation effects of serum lipids were evaluated through causal mediation analyses.
A total of 837 participants were newly diagnosed with hyperuricemia. The odds ratios of hyperuricemia associated with an interquartile range (IQR) increase in PM1, PM2.5, and PM10 (IQR: 21.10, 25.78, 30.43 μg m−3) were 1.72 (95% CI: 1.23, 2.39), 2.68 (95% CI: 1.59, 4.49), and 1.81 (95% CI: 1.20, 2.72), respectively. The association between PM2.5, PM1, and PM10 on hyperuricemia was mediated by HDL-C (10%) and LDL-C (3%).
Higher particulate matter exposure was associated with higher hyperuricemia incidence. The decline in HDL-C and rise in LDL-C partially mediated this association. These findings were conducive to scientific research about the underlying mechanism of PM on hyperuricemia.
•Assessed the relation of PM exposure to hyperuricemia among the general population.•PM exposure increased the risk of hyperuricemia and alter the serum lipid profile.•High/Low-density lipoprotein cholesterol mediated the association of PM on HUA.</abstract><pub>Elsevier Inc</pub><doi>10.1016/j.envres.2022.113865</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-5713-3603</orcidid><orcidid>https://orcid.org/0000-0002-2498-9816</orcidid></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | Hyperuricemia Lipid profile Particulate matter Prospective study |
| title | The role of lipid profile in the relationship between particulate matters and hyperuricemia: A prospective population study |
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