LOXL3‐promoted hepatocellular carcinoma progression via promotion of Snail1/USP4‐mediated epithelial‐mesenchymal transition

Lysyl‐oxidase‐like 3 (LOXL3) was reported to be essential in epithelial‐mesenchymal transition (EMT) of cancers. However, the role of LOXL3 in hepatocellular carcinoma (HCC) remained unclear. In this study, we explored clinical significance, biological functions, and regulatory mechanisms of LOXL3 i...

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Veröffentlicht in:	Environmental toxicology 2022-10, Vol.37 (10), p.2540-2551
Hauptverfasser:	Li, Rong, Shang, Runze, Li, Shunle, Ren, Yifan, Shen, Lin, Yang, Longbao, Chen, Shuo, Chen, Xi, Li, Junhui, Xu, Meng
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cancer Catenin Cell lines EMT HCC Hepatocellular carcinoma In vivo methods and tests Liver cancer Mesenchyme Metastases Neoplasms Peptidase Peptidases Protein expression Proteins Regulatory mechanisms (biology) Reporter gene Signal transduction Signaling Silence Snail protein Snail1 Stabilizing Tumors Ubiquitin USP4 Wnt protein Wnt/β‐catenin signaling pathway
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