Gut microbiota induces DNA methylation via SCFAs predisposing obesity-prone individuals to diabetes

Obesity-prone (OP) individuals have a significant predisposition to obesity and diabetes. Previously, we have found that OP individuals, despite being normal in weight and BMI, have already exhibited diabetes-related DNA methylation signatures. However, the underlying mechanisms remain obscure. Here...

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Veröffentlicht in:	Pharmacological research 2022-08, Vol.182, p.106355-106355, Article 106355
Hauptverfasser:	Guo, Wenqian, Zhang, Zengliang, Li, Lingru, Liang, Xue, Wu, Yuqi, Wang, Xiaolu, Ma, Han, Cheng, Jinjun, Zhang, Anqi, Tang, Ping, Wang, Chong-Zhi, Wan, Jin-Yi, Yao, Haiqiang, Yuan, Chun-Su
Format:	Artikel
Sprache:	eng
Schlagworte:	DAB1 DNA methylation Gut microbiota Obesity-prone Propionate SCFAs
Online-Zugang:	Volltext
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