Synthesis of Phosphorodiamidate Morpholino Oligonucleotides Using Trityl and Fmoc Chemistry in an Automated Oligo Synthesizer

Phosphorodiamidate morpholino oligonucleotides (PMOs) constitute 3 out of the 11 FDA-approved oligonucleotide-based drugs in the last 6 years. PMOs can effectively silence disease-causing genes and modify splicing. However, PMO synthesis has remained challenging for a variety of reasons: inefficient...

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Veröffentlicht in:	Journal of organic chemistry 2022-08, Vol.87 (15), p.9466-9478
Hauptverfasser:	Kundu, Jayanta, Ghosh, Atanu, Ghosh, Ujjwal, Das, Arnab, Nagar, Dhriti, Pattanayak, Sankha, Ghose, Aurnab, Sinha, Surajit
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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