Recent advances in cytoplasmic lipid droplet metabolism in intestinal enterocyte
Processing of dietary fats in the intestine is a highly regulated process that influences whole-body energy homeostasis and multiple physiological functions. Dysregulated lipid handling in the intestine leads to dyslipidemia and atherosclerotic cardiovascular disease. In intestinal enterocytes, lipi...
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| Veröffentlicht in: | Biochimica et biophysica acta. Molecular and cell biology of lipids 2022-10, Vol.1867 (10), p.159197-159197, Article 159197 |
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| container_end_page | 159197 |
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| container_issue | 10 |
| container_start_page | 159197 |
| container_title | Biochimica et biophysica acta. Molecular and cell biology of lipids |
| container_volume | 1867 |
| creator | Ghanem, Murooj Lewis, Gary F. Xiao, Changting |
| description | Processing of dietary fats in the intestine is a highly regulated process that influences whole-body energy homeostasis and multiple physiological functions. Dysregulated lipid handling in the intestine leads to dyslipidemia and atherosclerotic cardiovascular disease. In intestinal enterocytes, lipids are incorporated into lipoproteins and cytoplasmic lipid droplets (CLDs). Lipoprotein synthesis and CLD metabolism are inter-connected pathways with multiple points of regulation. This review aims to highlight recent advances in the regulatory mechanisms of lipid processing in the enterocyte, with particular focus on CLDs. In-depth understanding of the regulation of lipid metabolism in the enterocyte may help identify therapeutic targets for the treatment and prevention of metabolic disorders. |
| doi_str_mv | 10.1016/j.bbalip.2022.159197 |
| format | Article |
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| identifier | ISSN: 1388-1981 |
| ispartof | Biochimica et biophysica acta. Molecular and cell biology of lipids, 2022-10, Vol.1867 (10), p.159197-159197, Article 159197 |
| issn | 1388-1981 1879-2618 |
| language | eng |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Cytoplasmic lipid droplet Enterocyte Intestine Triacylglycerol |
| title | Recent advances in cytoplasmic lipid droplet metabolism in intestinal enterocyte |
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