Novel application of a Co‐Fermented postbiotics of TYCA06/AP‐32/CP‐9/collagen in the improvement of acne vulgaris—A randomized clinical study of efficacy evaluation
Background Acne vulgaris is a chronic inflammatory skin disease. If skin lesions are not treated well in time, they can leave a permanent impact on the appearance and a negative influence on personal confidence. The common therapy for acne symptom includes antibiotics, benzoyl peroxide, and azeleic...
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| Veröffentlicht in: | Journal of cosmetic dermatology 2022-11, Vol.21 (11), p.6249-6260 |
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| creator | Ho, Hsieh‐Hsun Chen, Ching‐Wei Yi, Tsai‐Hsuan Huang, Yu‐Fen Kuo, Yi‐Wei Lin, Jia‐Hung Chen, Jui‐Fen Tsai, Shin‐Yu Chan, Leong‐Perng Liang, Chia‐Hua |
| description | Background
Acne vulgaris is a chronic inflammatory skin disease. If skin lesions are not treated well in time, they can leave a permanent impact on the appearance and a negative influence on personal confidence. The common therapy for acne symptom includes antibiotics, benzoyl peroxide, and azeleic acid. However, those medications have side effects, and the long‐term use should be cautious. Therefore, it is necessary to develop a safe and effective material, which is more suitable for daily use.
Objective
Collagen was selected to co‐ferment with three probiotic strains TYCA06/AP‐32/CP‐9 (TAC) due to its excellent feature on wound healing. The fermented material was added into cosmetic gel and applied on subjects' acne lesions. The antimicrobial activity against Propionibacterium acnes and anti‐inflammation effect around lesion area were investigated in a 4‐week clinical study.
Material and Methods
An anti‐P. acnes assay, a keratinocytes HaCaT cell‐based wound healing assay, and a cytokine assay on thymic stromal lymphopoietin (TSLP) and interleukin (IL)‐33 were used to evaluate the function of the fermented material in vitro. The TAC/Collagen formula was further incorporated into a cosmetic gel, and the human clinical trial was carried out by applying this gel on 20 volunteers' face with acne vulgaris. The moisture score, sebum content, inflammation, porphyrins numbers, and brown spot number of whole face were observed and recorded.
Results
The postbiotics of the TAC/Collagen displayed a good growth inhibition against P. acnes and reduced TSLP and IL‐33 inflammation in vitro. This TAC/Collagen formula enhanced the wound healing in HaCaT cell culture. The result of the clinical trial showed the TAC/Collagen gel improved the moisture score and inflammation index of the skin in vivo. In addition, this TAC/Collagen gel also improved the wound healing of acne symptom in volunteers with acne vulgaris. Moreover, this TAC/Collagen gel reduced the number of the porphyrins and brown spots on facial skin.
Conclusion
These postbiotics of TAC/Collagen have beneficial effects on skin health and are able to ameliorate the redness, inflammation, and acne symptom in acne vulgaris patients. |
| doi_str_mv | 10.1111/jocd.15228 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2688521457</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2688521457</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3298-d4b687fad2604646582a1d770e27edd11f0abaa954356bd695a82647fb2194643</originalsourceid><addsrcrecordid>eNp9kU9O3DAUh60KVP510wNUXqJKw9hO7DjLUehQEIIuYNFV5Ngv1MiJ0ziZarriCCw4Rk_FSXBmgGW9eZb9-XvP-iH0mZITGtf83mtzQjlj8gPap2mWzBgVfOd9n5A9dBDCPSE0yyn_iPYSLqmkSbqP_l35FTisus5ZrQbrW-xrrHDhnx8el9A30A5gcOfDUFk_WB2m-5ufxYKI-eJHhBI2L6aaz7V3Tt1Bi22Lh1-AbdP10T4pNlLdAl6N7k71Njw_PC1wr1rjG_s3NtDOtnEAh8MwmvWEQ13HA73GsFJu3Ix2hHZr5QJ8eq2H6Hb57ab4Pru8PjsvFpcznbBczkxaCZnVyjBBUpEKLpmiJssIsAyMobQmqlIq52nCRWVEzpVkIs3qitE8PkgO0fHWG-f_PUIYysYGDfF3LfgxlExIyRlNeRbRr1tU9z6EHuqy622j-nVJSTmlU07plJt0Ivzl1TtWDZh39C2OCNAt8Mc6WP9HVV5cF6db6Qtv2p7m</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2688521457</pqid></control><display><type>article</type><title>Novel application of a Co‐Fermented postbiotics of TYCA06/AP‐32/CP‐9/collagen in the improvement of acne vulgaris—A randomized clinical study of efficacy evaluation</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Ho, Hsieh‐Hsun ; Chen, Ching‐Wei ; Yi, Tsai‐Hsuan ; Huang, Yu‐Fen ; Kuo, Yi‐Wei ; Lin, Jia‐Hung ; Chen, Jui‐Fen ; Tsai, Shin‐Yu ; Chan, Leong‐Perng ; Liang, Chia‐Hua</creator><creatorcontrib>Ho, Hsieh‐Hsun ; Chen, Ching‐Wei ; Yi, Tsai‐Hsuan ; Huang, Yu‐Fen ; Kuo, Yi‐Wei ; Lin, Jia‐Hung ; Chen, Jui‐Fen ; Tsai, Shin‐Yu ; Chan, Leong‐Perng ; Liang, Chia‐Hua</creatorcontrib><description>Background
Acne vulgaris is a chronic inflammatory skin disease. If skin lesions are not treated well in time, they can leave a permanent impact on the appearance and a negative influence on personal confidence. The common therapy for acne symptom includes antibiotics, benzoyl peroxide, and azeleic acid. However, those medications have side effects, and the long‐term use should be cautious. Therefore, it is necessary to develop a safe and effective material, which is more suitable for daily use.
Objective
Collagen was selected to co‐ferment with three probiotic strains TYCA06/AP‐32/CP‐9 (TAC) due to its excellent feature on wound healing. The fermented material was added into cosmetic gel and applied on subjects' acne lesions. The antimicrobial activity against Propionibacterium acnes and anti‐inflammation effect around lesion area were investigated in a 4‐week clinical study.
Material and Methods
An anti‐P. acnes assay, a keratinocytes HaCaT cell‐based wound healing assay, and a cytokine assay on thymic stromal lymphopoietin (TSLP) and interleukin (IL)‐33 were used to evaluate the function of the fermented material in vitro. The TAC/Collagen formula was further incorporated into a cosmetic gel, and the human clinical trial was carried out by applying this gel on 20 volunteers' face with acne vulgaris. The moisture score, sebum content, inflammation, porphyrins numbers, and brown spot number of whole face were observed and recorded.
Results
The postbiotics of the TAC/Collagen displayed a good growth inhibition against P. acnes and reduced TSLP and IL‐33 inflammation in vitro. This TAC/Collagen formula enhanced the wound healing in HaCaT cell culture. The result of the clinical trial showed the TAC/Collagen gel improved the moisture score and inflammation index of the skin in vivo. In addition, this TAC/Collagen gel also improved the wound healing of acne symptom in volunteers with acne vulgaris. Moreover, this TAC/Collagen gel reduced the number of the porphyrins and brown spots on facial skin.
Conclusion
These postbiotics of TAC/Collagen have beneficial effects on skin health and are able to ameliorate the redness, inflammation, and acne symptom in acne vulgaris patients.</description><identifier>ISSN: 1473-2130</identifier><identifier>EISSN: 1473-2165</identifier><identifier>DOI: 10.1111/jocd.15228</identifier><identifier>PMID: 35818134</identifier><language>eng</language><publisher>England</publisher><subject>acne vulgaris ; Acne Vulgaris - diagnosis ; Anti-Bacterial Agents ; Benzoyl Peroxide ; Collagen - pharmacology ; Cosmetics - pharmacology ; Cytokines ; Dermatologic Agents - therapeutic use ; Humans ; postbiotics ; Propionibacterium acnes ; skin</subject><ispartof>Journal of cosmetic dermatology, 2022-11, Vol.21 (11), p.6249-6260</ispartof><rights>2022 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3298-d4b687fad2604646582a1d770e27edd11f0abaa954356bd695a82647fb2194643</citedby><cites>FETCH-LOGICAL-c3298-d4b687fad2604646582a1d770e27edd11f0abaa954356bd695a82647fb2194643</cites><orcidid>0000-0001-8589-4805</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjocd.15228$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjocd.15228$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35818134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ho, Hsieh‐Hsun</creatorcontrib><creatorcontrib>Chen, Ching‐Wei</creatorcontrib><creatorcontrib>Yi, Tsai‐Hsuan</creatorcontrib><creatorcontrib>Huang, Yu‐Fen</creatorcontrib><creatorcontrib>Kuo, Yi‐Wei</creatorcontrib><creatorcontrib>Lin, Jia‐Hung</creatorcontrib><creatorcontrib>Chen, Jui‐Fen</creatorcontrib><creatorcontrib>Tsai, Shin‐Yu</creatorcontrib><creatorcontrib>Chan, Leong‐Perng</creatorcontrib><creatorcontrib>Liang, Chia‐Hua</creatorcontrib><title>Novel application of a Co‐Fermented postbiotics of TYCA06/AP‐32/CP‐9/collagen in the improvement of acne vulgaris—A randomized clinical study of efficacy evaluation</title><title>Journal of cosmetic dermatology</title><addtitle>J Cosmet Dermatol</addtitle><description>Background
Acne vulgaris is a chronic inflammatory skin disease. If skin lesions are not treated well in time, they can leave a permanent impact on the appearance and a negative influence on personal confidence. The common therapy for acne symptom includes antibiotics, benzoyl peroxide, and azeleic acid. However, those medications have side effects, and the long‐term use should be cautious. Therefore, it is necessary to develop a safe and effective material, which is more suitable for daily use.
Objective
Collagen was selected to co‐ferment with three probiotic strains TYCA06/AP‐32/CP‐9 (TAC) due to its excellent feature on wound healing. The fermented material was added into cosmetic gel and applied on subjects' acne lesions. The antimicrobial activity against Propionibacterium acnes and anti‐inflammation effect around lesion area were investigated in a 4‐week clinical study.
Material and Methods
An anti‐P. acnes assay, a keratinocytes HaCaT cell‐based wound healing assay, and a cytokine assay on thymic stromal lymphopoietin (TSLP) and interleukin (IL)‐33 were used to evaluate the function of the fermented material in vitro. The TAC/Collagen formula was further incorporated into a cosmetic gel, and the human clinical trial was carried out by applying this gel on 20 volunteers' face with acne vulgaris. The moisture score, sebum content, inflammation, porphyrins numbers, and brown spot number of whole face were observed and recorded.
Results
The postbiotics of the TAC/Collagen displayed a good growth inhibition against P. acnes and reduced TSLP and IL‐33 inflammation in vitro. This TAC/Collagen formula enhanced the wound healing in HaCaT cell culture. The result of the clinical trial showed the TAC/Collagen gel improved the moisture score and inflammation index of the skin in vivo. In addition, this TAC/Collagen gel also improved the wound healing of acne symptom in volunteers with acne vulgaris. Moreover, this TAC/Collagen gel reduced the number of the porphyrins and brown spots on facial skin.
Conclusion
These postbiotics of TAC/Collagen have beneficial effects on skin health and are able to ameliorate the redness, inflammation, and acne symptom in acne vulgaris patients.</description><subject>acne vulgaris</subject><subject>Acne Vulgaris - diagnosis</subject><subject>Anti-Bacterial Agents</subject><subject>Benzoyl Peroxide</subject><subject>Collagen - pharmacology</subject><subject>Cosmetics - pharmacology</subject><subject>Cytokines</subject><subject>Dermatologic Agents - therapeutic use</subject><subject>Humans</subject><subject>postbiotics</subject><subject>Propionibacterium acnes</subject><subject>skin</subject><issn>1473-2130</issn><issn>1473-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9O3DAUh60KVP510wNUXqJKw9hO7DjLUehQEIIuYNFV5Ngv1MiJ0ziZarriCCw4Rk_FSXBmgGW9eZb9-XvP-iH0mZITGtf83mtzQjlj8gPap2mWzBgVfOd9n5A9dBDCPSE0yyn_iPYSLqmkSbqP_l35FTisus5ZrQbrW-xrrHDhnx8el9A30A5gcOfDUFk_WB2m-5ufxYKI-eJHhBI2L6aaz7V3Tt1Bi22Lh1-AbdP10T4pNlLdAl6N7k71Njw_PC1wr1rjG_s3NtDOtnEAh8MwmvWEQ13HA73GsFJu3Ix2hHZr5QJ8eq2H6Hb57ab4Pru8PjsvFpcznbBczkxaCZnVyjBBUpEKLpmiJssIsAyMobQmqlIq52nCRWVEzpVkIs3qitE8PkgO0fHWG-f_PUIYysYGDfF3LfgxlExIyRlNeRbRr1tU9z6EHuqy622j-nVJSTmlU07plJt0Ivzl1TtWDZh39C2OCNAt8Mc6WP9HVV5cF6db6Qtv2p7m</recordid><startdate>202211</startdate><enddate>202211</enddate><creator>Ho, Hsieh‐Hsun</creator><creator>Chen, Ching‐Wei</creator><creator>Yi, Tsai‐Hsuan</creator><creator>Huang, Yu‐Fen</creator><creator>Kuo, Yi‐Wei</creator><creator>Lin, Jia‐Hung</creator><creator>Chen, Jui‐Fen</creator><creator>Tsai, Shin‐Yu</creator><creator>Chan, Leong‐Perng</creator><creator>Liang, Chia‐Hua</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8589-4805</orcidid></search><sort><creationdate>202211</creationdate><title>Novel application of a Co‐Fermented postbiotics of TYCA06/AP‐32/CP‐9/collagen in the improvement of acne vulgaris—A randomized clinical study of efficacy evaluation</title><author>Ho, Hsieh‐Hsun ; Chen, Ching‐Wei ; Yi, Tsai‐Hsuan ; Huang, Yu‐Fen ; Kuo, Yi‐Wei ; Lin, Jia‐Hung ; Chen, Jui‐Fen ; Tsai, Shin‐Yu ; Chan, Leong‐Perng ; Liang, Chia‐Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3298-d4b687fad2604646582a1d770e27edd11f0abaa954356bd695a82647fb2194643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>acne vulgaris</topic><topic>Acne Vulgaris - diagnosis</topic><topic>Anti-Bacterial Agents</topic><topic>Benzoyl Peroxide</topic><topic>Collagen - pharmacology</topic><topic>Cosmetics - pharmacology</topic><topic>Cytokines</topic><topic>Dermatologic Agents - therapeutic use</topic><topic>Humans</topic><topic>postbiotics</topic><topic>Propionibacterium acnes</topic><topic>skin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ho, Hsieh‐Hsun</creatorcontrib><creatorcontrib>Chen, Ching‐Wei</creatorcontrib><creatorcontrib>Yi, Tsai‐Hsuan</creatorcontrib><creatorcontrib>Huang, Yu‐Fen</creatorcontrib><creatorcontrib>Kuo, Yi‐Wei</creatorcontrib><creatorcontrib>Lin, Jia‐Hung</creatorcontrib><creatorcontrib>Chen, Jui‐Fen</creatorcontrib><creatorcontrib>Tsai, Shin‐Yu</creatorcontrib><creatorcontrib>Chan, Leong‐Perng</creatorcontrib><creatorcontrib>Liang, Chia‐Hua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cosmetic dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ho, Hsieh‐Hsun</au><au>Chen, Ching‐Wei</au><au>Yi, Tsai‐Hsuan</au><au>Huang, Yu‐Fen</au><au>Kuo, Yi‐Wei</au><au>Lin, Jia‐Hung</au><au>Chen, Jui‐Fen</au><au>Tsai, Shin‐Yu</au><au>Chan, Leong‐Perng</au><au>Liang, Chia‐Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel application of a Co‐Fermented postbiotics of TYCA06/AP‐32/CP‐9/collagen in the improvement of acne vulgaris—A randomized clinical study of efficacy evaluation</atitle><jtitle>Journal of cosmetic dermatology</jtitle><addtitle>J Cosmet Dermatol</addtitle><date>2022-11</date><risdate>2022</risdate><volume>21</volume><issue>11</issue><spage>6249</spage><epage>6260</epage><pages>6249-6260</pages><issn>1473-2130</issn><eissn>1473-2165</eissn><abstract>Background
Acne vulgaris is a chronic inflammatory skin disease. If skin lesions are not treated well in time, they can leave a permanent impact on the appearance and a negative influence on personal confidence. The common therapy for acne symptom includes antibiotics, benzoyl peroxide, and azeleic acid. However, those medications have side effects, and the long‐term use should be cautious. Therefore, it is necessary to develop a safe and effective material, which is more suitable for daily use.
Objective
Collagen was selected to co‐ferment with three probiotic strains TYCA06/AP‐32/CP‐9 (TAC) due to its excellent feature on wound healing. The fermented material was added into cosmetic gel and applied on subjects' acne lesions. The antimicrobial activity against Propionibacterium acnes and anti‐inflammation effect around lesion area were investigated in a 4‐week clinical study.
Material and Methods
An anti‐P. acnes assay, a keratinocytes HaCaT cell‐based wound healing assay, and a cytokine assay on thymic stromal lymphopoietin (TSLP) and interleukin (IL)‐33 were used to evaluate the function of the fermented material in vitro. The TAC/Collagen formula was further incorporated into a cosmetic gel, and the human clinical trial was carried out by applying this gel on 20 volunteers' face with acne vulgaris. The moisture score, sebum content, inflammation, porphyrins numbers, and brown spot number of whole face were observed and recorded.
Results
The postbiotics of the TAC/Collagen displayed a good growth inhibition against P. acnes and reduced TSLP and IL‐33 inflammation in vitro. This TAC/Collagen formula enhanced the wound healing in HaCaT cell culture. The result of the clinical trial showed the TAC/Collagen gel improved the moisture score and inflammation index of the skin in vivo. In addition, this TAC/Collagen gel also improved the wound healing of acne symptom in volunteers with acne vulgaris. Moreover, this TAC/Collagen gel reduced the number of the porphyrins and brown spots on facial skin.
Conclusion
These postbiotics of TAC/Collagen have beneficial effects on skin health and are able to ameliorate the redness, inflammation, and acne symptom in acne vulgaris patients.</abstract><cop>England</cop><pmid>35818134</pmid><doi>10.1111/jocd.15228</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-8589-4805</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | acne vulgaris Acne Vulgaris - diagnosis Anti-Bacterial Agents Benzoyl Peroxide Collagen - pharmacology Cosmetics - pharmacology Cytokines Dermatologic Agents - therapeutic use Humans postbiotics Propionibacterium acnes skin |
| title | Novel application of a Co‐Fermented postbiotics of TYCA06/AP‐32/CP‐9/collagen in the improvement of acne vulgaris—A randomized clinical study of efficacy evaluation |
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