Local IL-10 replacement therapy was effective for steroid-insensitive asthma in mice

•Effects of intratracheal IL-10 dosing on steroid-insensitive asthma were assessed.•IL-10 dosing suppressed the development of airway hyperresponsiveness.•IL-10 dosing decreased infiltrations of eosinophils and neutrophils into the lung.•IL-10 dosing attenuated the proliferation of ICAM-1+ and VCAM-...

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Veröffentlicht in:	International immunopharmacology 2022-09, Vol.110, p.109037-109037, Article 109037
Hauptverfasser:	Matsuda, Masaya, Inaba, Miki, Hamaguchi, Junpei, Tomita, Hiro, Omori, Miyu, Shimora, Hayato, Sakae, Harumi, Kitatani, Kazuyuki, Nabe, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy Asthma Corticosteroids Eosinophil Interleukin-10 Neutrophil
Online-Zugang:	Volltext
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