Ethyl chloride spray, a local anesthetic in arterial blood gas sampling: A randomized, controlled, double-blinded study
Arterial blood gas sampling provides useful information on respiratory parameters and acid-base balance. However, this procedure is painful and uncomfortable for the patient. Therefore, this study aimed to examine the analgesic efficacy of ethyl chloride spray compared to a placebo during radial art...
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Veröffentlicht in: | The American journal of emergency medicine 2022-09, Vol.59, p.63-66 |
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description | Arterial blood gas sampling provides useful information on respiratory parameters and acid-base balance. However, this procedure is painful and uncomfortable for the patient. Therefore, this study aimed to examine the analgesic efficacy of ethyl chloride spray compared to a placebo during radial artery blood gas sampling.
This randomized, double-blind, placebo-controlled study was conducted at the emergency department of a tertiary hospital. A total of 202 patients were randomly divided into two groups: ethyl chloride spray (n = 101) and placebo (n = 101). The analgesic efficacy of ethyl chloride spray was compared with the placebo using the Visual Analog Scale (VAS).
The VAS score was determined to be 4 [interquartile range (IQR): 1.0] for the ethyl chloride spray group and 5 (IQR: 1.0) for the placebo group. The analgesic efficacy of ethyl chloride spray in reducing pain was statistically significantly higher compared to the placebo (p = 0.000).
Ethyl chloride spray has analgesic efficacy in arterial blood gas sampling. Therefore, the use of this spray provides an analgesic effect on patients during arterial blood gas sampling performed in the emergency department. |
doi_str_mv | 10.1016/j.ajem.2022.06.038 |
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This randomized, double-blind, placebo-controlled study was conducted at the emergency department of a tertiary hospital. A total of 202 patients were randomly divided into two groups: ethyl chloride spray (n = 101) and placebo (n = 101). The analgesic efficacy of ethyl chloride spray was compared with the placebo using the Visual Analog Scale (VAS).
The VAS score was determined to be 4 [interquartile range (IQR): 1.0] for the ethyl chloride spray group and 5 (IQR: 1.0) for the placebo group. The analgesic efficacy of ethyl chloride spray in reducing pain was statistically significantly higher compared to the placebo (p = 0.000).
Ethyl chloride spray has analgesic efficacy in arterial blood gas sampling. Therefore, the use of this spray provides an analgesic effect on patients during arterial blood gas sampling performed in the emergency department.</description><identifier>ISSN: 0735-6757</identifier><identifier>EISSN: 1532-8171</identifier><identifier>DOI: 10.1016/j.ajem.2022.06.038</identifier><identifier>PMID: 35797844</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acid-base status ; Analgesics ; Analgesics - therapeutic use ; Anesthesia ; Anesthesia, Local - methods ; Anesthetics, Local ; Arterial blood gas sampling ; Blood ; Chloride ; Chlorides ; Double-Blind Method ; Emergency medical care ; Ethyl chloride ; Ethyl Chloride - therapeutic use ; Humans ; Intervention ; Local anesthesia ; Normal distribution ; Pain ; Pain - drug therapy ; Pain management ; Pain Measurement ; Patients ; Placebos ; Sample size ; Sampling ; Software ; Statistical analysis ; Thoracic surgery ; Veins & arteries</subject><ispartof>The American journal of emergency medicine, 2022-09, Vol.59, p.63-66</ispartof><rights>2022 Elsevier Inc.</rights><rights>Copyright © 2022 Elsevier Inc. All rights reserved.</rights><rights>2022. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c314t-20cc61f1927c29a721edb8ce3a4bd6cd5c70237804f3fd24993a6f2efe349dae3</citedby><cites>FETCH-LOGICAL-c314t-20cc61f1927c29a721edb8ce3a4bd6cd5c70237804f3fd24993a6f2efe349dae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2697660983?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002,64392,64394,64396,72476</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35797844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cakmak, Fatma</creatorcontrib><creatorcontrib>Gur, Ali</creatorcontrib><title>Ethyl chloride spray, a local anesthetic in arterial blood gas sampling: A randomized, controlled, double-blinded study</title><title>The American journal of emergency medicine</title><addtitle>Am J Emerg Med</addtitle><description>Arterial blood gas sampling provides useful information on respiratory parameters and acid-base balance. However, this procedure is painful and uncomfortable for the patient. Therefore, this study aimed to examine the analgesic efficacy of ethyl chloride spray compared to a placebo during radial artery blood gas sampling.
This randomized, double-blind, placebo-controlled study was conducted at the emergency department of a tertiary hospital. A total of 202 patients were randomly divided into two groups: ethyl chloride spray (n = 101) and placebo (n = 101). The analgesic efficacy of ethyl chloride spray was compared with the placebo using the Visual Analog Scale (VAS).
The VAS score was determined to be 4 [interquartile range (IQR): 1.0] for the ethyl chloride spray group and 5 (IQR: 1.0) for the placebo group. The analgesic efficacy of ethyl chloride spray in reducing pain was statistically significantly higher compared to the placebo (p = 0.000).
Ethyl chloride spray has analgesic efficacy in arterial blood gas sampling. Therefore, the use of this spray provides an analgesic effect on patients during arterial blood gas sampling performed in the emergency department.</description><subject>Acid-base status</subject><subject>Analgesics</subject><subject>Analgesics - therapeutic use</subject><subject>Anesthesia</subject><subject>Anesthesia, Local - methods</subject><subject>Anesthetics, Local</subject><subject>Arterial blood gas sampling</subject><subject>Blood</subject><subject>Chloride</subject><subject>Chlorides</subject><subject>Double-Blind Method</subject><subject>Emergency medical care</subject><subject>Ethyl chloride</subject><subject>Ethyl Chloride - therapeutic use</subject><subject>Humans</subject><subject>Intervention</subject><subject>Local anesthesia</subject><subject>Normal distribution</subject><subject>Pain</subject><subject>Pain - drug therapy</subject><subject>Pain management</subject><subject>Pain Measurement</subject><subject>Patients</subject><subject>Placebos</subject><subject>Sample size</subject><subject>Sampling</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Thoracic surgery</subject><subject>Veins & arteries</subject><issn>0735-6757</issn><issn>1532-8171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU1v1DAQhi0EokvhD3BAlrhwaIK_YseIS1WVD6kSFzhbjj3pOnLixU5Ay6_Hqy0cOHDyyHrm1cw8CL2kpKWEyrdTayeYW0YYa4lsCe8foR3tOGt6quhjtCOKd41UnbpAz0qZCKFUdOIpuuCd0qoXYod-3q77Y8RuH1MOHnA5ZHu8whbH5GzEdoGy7mENDocF27xCDvV7iCl5fG8LLnY-xLDcv8PXONvFpzn8An-FXVrWnGI81T5tQ4RmqJwHj8u6-eNz9GS0scCLh_cSfftw-_XmU3P35ePnm-u7xnEq1oYR5yQdqWbKMW0Vo-CH3gG3YvDS-c4pwrjqiRj56JnQmls5MhiBC-0t8Ev05px7yOn7VpcxcygOYqybpa0YJnulGKeaVvT1P-iUtrzU6SqllZRE97xS7Ey5nErJMJpDDrPNR0OJOWkxkzlpMScthkhTtdSmVw_R2zCD_9vyx0MF3p8BqLf4ESCb4gIsDnzI4FbjU_hf_m-wH58B</recordid><startdate>202209</startdate><enddate>202209</enddate><creator>Cakmak, Fatma</creator><creator>Gur, Ali</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>202209</creationdate><title>Ethyl chloride spray, a local anesthetic in arterial blood gas sampling: A randomized, controlled, double-blinded study</title><author>Cakmak, Fatma ; Gur, Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-20cc61f1927c29a721edb8ce3a4bd6cd5c70237804f3fd24993a6f2efe349dae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acid-base status</topic><topic>Analgesics</topic><topic>Analgesics - therapeutic use</topic><topic>Anesthesia</topic><topic>Anesthesia, Local - methods</topic><topic>Anesthetics, Local</topic><topic>Arterial blood gas sampling</topic><topic>Blood</topic><topic>Chloride</topic><topic>Chlorides</topic><topic>Double-Blind Method</topic><topic>Emergency medical care</topic><topic>Ethyl chloride</topic><topic>Ethyl Chloride - therapeutic use</topic><topic>Humans</topic><topic>Intervention</topic><topic>Local anesthesia</topic><topic>Normal distribution</topic><topic>Pain</topic><topic>Pain - drug therapy</topic><topic>Pain management</topic><topic>Pain Measurement</topic><topic>Patients</topic><topic>Placebos</topic><topic>Sample size</topic><topic>Sampling</topic><topic>Software</topic><topic>Statistical analysis</topic><topic>Thoracic surgery</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cakmak, Fatma</creatorcontrib><creatorcontrib>Gur, Ali</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cakmak, Fatma</au><au>Gur, Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ethyl chloride spray, a local anesthetic in arterial blood gas sampling: A randomized, controlled, double-blinded study</atitle><jtitle>The American journal of emergency medicine</jtitle><addtitle>Am J Emerg Med</addtitle><date>2022-09</date><risdate>2022</risdate><volume>59</volume><spage>63</spage><epage>66</epage><pages>63-66</pages><issn>0735-6757</issn><eissn>1532-8171</eissn><abstract>Arterial blood gas sampling provides useful information on respiratory parameters and acid-base balance. However, this procedure is painful and uncomfortable for the patient. Therefore, this study aimed to examine the analgesic efficacy of ethyl chloride spray compared to a placebo during radial artery blood gas sampling.
This randomized, double-blind, placebo-controlled study was conducted at the emergency department of a tertiary hospital. A total of 202 patients were randomly divided into two groups: ethyl chloride spray (n = 101) and placebo (n = 101). The analgesic efficacy of ethyl chloride spray was compared with the placebo using the Visual Analog Scale (VAS).
The VAS score was determined to be 4 [interquartile range (IQR): 1.0] for the ethyl chloride spray group and 5 (IQR: 1.0) for the placebo group. The analgesic efficacy of ethyl chloride spray in reducing pain was statistically significantly higher compared to the placebo (p = 0.000).
Ethyl chloride spray has analgesic efficacy in arterial blood gas sampling. Therefore, the use of this spray provides an analgesic effect on patients during arterial blood gas sampling performed in the emergency department.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>35797844</pmid><doi>10.1016/j.ajem.2022.06.038</doi><tpages>4</tpages></addata></record> |
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subjects | Acid-base status Analgesics Analgesics - therapeutic use Anesthesia Anesthesia, Local - methods Anesthetics, Local Arterial blood gas sampling Blood Chloride Chlorides Double-Blind Method Emergency medical care Ethyl chloride Ethyl Chloride - therapeutic use Humans Intervention Local anesthesia Normal distribution Pain Pain - drug therapy Pain management Pain Measurement Patients Placebos Sample size Sampling Software Statistical analysis Thoracic surgery Veins & arteries |
title | Ethyl chloride spray, a local anesthetic in arterial blood gas sampling: A randomized, controlled, double-blinded study |
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