Features of cystadenofibroma on magnetic resonance imaging: an update using the O-RADS lexicon and considering diffusion-weighted and perfusion imaging
•Cystoadenofibroma has typical “dark-dark appearance” of the solid component.•On Perfusion Weighted Images, solid tissue shows type I time-intensity curve.•Solid tissue shows no significant restriction in Diffusion Weighted Images.•O-RADS score is able to stratify the risk of malignancy in our entir...
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| Veröffentlicht in: | European journal of radiology 2022-09, Vol.154, p.110429-110429, Article 110429 |
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| container_title | European journal of radiology |
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| creator | Avesani, Giacomo Elia, Lorenzo Anghelone, Andrea Giovanni Perazzolo, Alessio Panico, Camilla Di Paola, Valerio Gui, Benedetta Rodolfino, Elena Moro, Francesca Testa, Antonia Carla Manfredi, Riccardo |
| description | •Cystoadenofibroma has typical “dark-dark appearance” of the solid component.•On Perfusion Weighted Images, solid tissue shows type I time-intensity curve.•Solid tissue shows no significant restriction in Diffusion Weighted Images.•O-RADS score is able to stratify the risk of malignancy in our entire sample.
Cystadenofibroma (CAF) is a rare tumour of the ovary that can be confused with a borderline or malignant lesion due to its morphological characteristics. The study aims to analyse the MRI (magnetic resonance imaging) features of histologically proven ovarian cystadenofibromas according to lexicon-based and O-RADS (Ovarian-Adnexal Reporting and Data System) descriptors, with particular attention to time-intensity curves (TIC) and Diffusion-Weighted sequences (DWI); we also wanted to test the performance of O-RADS MRI risk stratification system in this particular subgroup of patients.
We have included all patients who performed MR between October 2019 and December 2021 after an inconclusive trans-vaginal ultrasound. All patients underwent surgery with histological results of CAF. According to the O-RADS lexicon, we reported the morphological characteristics of each lesion and their appearance in the perfusion-weighted imaging (PWI) and DWI sequences. We assessed the risk of malignancy for each lesion through O-RADS MRI score.
Twenty-one histologically proven CAF were analysed, of which 20 benign and one borderline with degeneration into adenocarcinoma. We described the typical morphological characteristics of CAF according to lexicon-based and O-RADS descriptors. Analysis of time-intensity curves (TIC) in PWI sequences showed a slow and progressive enhancement of solid tissue (type I curve), configuring an O-RADS score of 2 or 3, except for the only malignant lesion that showed a type II curve and restriction in DWI (O-RADS 4).
Our study is the largest comprising PWI and DWI sequences, highlighting their pivotal role. O-RADS score correctly classified the masses as benign or malignant. |
| doi_str_mv | 10.1016/j.ejrad.2022.110429 |
| format | Article |
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Cystadenofibroma (CAF) is a rare tumour of the ovary that can be confused with a borderline or malignant lesion due to its morphological characteristics. The study aims to analyse the MRI (magnetic resonance imaging) features of histologically proven ovarian cystadenofibromas according to lexicon-based and O-RADS (Ovarian-Adnexal Reporting and Data System) descriptors, with particular attention to time-intensity curves (TIC) and Diffusion-Weighted sequences (DWI); we also wanted to test the performance of O-RADS MRI risk stratification system in this particular subgroup of patients.
We have included all patients who performed MR between October 2019 and December 2021 after an inconclusive trans-vaginal ultrasound. All patients underwent surgery with histological results of CAF. According to the O-RADS lexicon, we reported the morphological characteristics of each lesion and their appearance in the perfusion-weighted imaging (PWI) and DWI sequences. We assessed the risk of malignancy for each lesion through O-RADS MRI score.
Twenty-one histologically proven CAF were analysed, of which 20 benign and one borderline with degeneration into adenocarcinoma. We described the typical morphological characteristics of CAF according to lexicon-based and O-RADS descriptors. Analysis of time-intensity curves (TIC) in PWI sequences showed a slow and progressive enhancement of solid tissue (type I curve), configuring an O-RADS score of 2 or 3, except for the only malignant lesion that showed a type II curve and restriction in DWI (O-RADS 4).
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Cystadenofibroma (CAF) is a rare tumour of the ovary that can be confused with a borderline or malignant lesion due to its morphological characteristics. The study aims to analyse the MRI (magnetic resonance imaging) features of histologically proven ovarian cystadenofibromas according to lexicon-based and O-RADS (Ovarian-Adnexal Reporting and Data System) descriptors, with particular attention to time-intensity curves (TIC) and Diffusion-Weighted sequences (DWI); we also wanted to test the performance of O-RADS MRI risk stratification system in this particular subgroup of patients.
We have included all patients who performed MR between October 2019 and December 2021 after an inconclusive trans-vaginal ultrasound. All patients underwent surgery with histological results of CAF. According to the O-RADS lexicon, we reported the morphological characteristics of each lesion and their appearance in the perfusion-weighted imaging (PWI) and DWI sequences. We assessed the risk of malignancy for each lesion through O-RADS MRI score.
Twenty-one histologically proven CAF were analysed, of which 20 benign and one borderline with degeneration into adenocarcinoma. We described the typical morphological characteristics of CAF according to lexicon-based and O-RADS descriptors. Analysis of time-intensity curves (TIC) in PWI sequences showed a slow and progressive enhancement of solid tissue (type I curve), configuring an O-RADS score of 2 or 3, except for the only malignant lesion that showed a type II curve and restriction in DWI (O-RADS 4).
Our study is the largest comprising PWI and DWI sequences, highlighting their pivotal role. O-RADS score correctly classified the masses as benign or malignant.</description><subject>Cystoadenofibroma</subject><subject>Magnetic resonance</subject><subject>O-RADS score</subject><subject>Perfusion weighted imaging</subject><subject>Time-intensity curve</subject><issn>0720-048X</issn><issn>1872-7727</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kU9P3DAQxa2qlbqFfoJefOSSZezEiYPEAVEolZCQ-CNxsxx7vHi1ay92QuGT9OvWS9prTyM9_d5o5j1CvjFYMmDt8XqJ66TtkgPnS8ag4f0HsmCy41XX8e4jWUDHoYJGPn4mX3JeA4Boer4gvy9Rj1PCTKOj5i2P2mKIzg8pbjWNgW71KuDoDS1MDDoYpL5oPqxOqA502lk9Ip1yEej4hPSmuj37fkc3-OpNsetgaZnZW0x7xHrnChxD9Qv96mlE-47sMM3yv-WH5JPTm4xf_84D8nB5cX9-VV3f_Ph5fnZdGd50spJ9U4O2wiDjKGo-uLZpuTDQ2h6dAe46yUTLTdGYkfUgBgDTCMn7djAg6gNyNO_dpfg8YR7V1meDm40OGKeseCtLgjUTsqD1jJoUc07o1C6Va9ObYqD2Nai1eq9B7WtQcw3FdTq7sHzx4jGpbDyWGK1PaEZlo_-v_w_ZgZPR</recordid><startdate>202209</startdate><enddate>202209</enddate><creator>Avesani, Giacomo</creator><creator>Elia, Lorenzo</creator><creator>Anghelone, Andrea Giovanni</creator><creator>Perazzolo, Alessio</creator><creator>Panico, Camilla</creator><creator>Di Paola, Valerio</creator><creator>Gui, Benedetta</creator><creator>Rodolfino, Elena</creator><creator>Moro, Francesca</creator><creator>Testa, Antonia Carla</creator><creator>Manfredi, Riccardo</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1234-003X</orcidid></search><sort><creationdate>202209</creationdate><title>Features of cystadenofibroma on magnetic resonance imaging: an update using the O-RADS lexicon and considering diffusion-weighted and perfusion imaging</title><author>Avesani, Giacomo ; Elia, Lorenzo ; Anghelone, Andrea Giovanni ; Perazzolo, Alessio ; Panico, Camilla ; Di Paola, Valerio ; Gui, Benedetta ; Rodolfino, Elena ; Moro, Francesca ; Testa, Antonia Carla ; Manfredi, Riccardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2478-89430ad5ce12e532bf64625c06d9efc02f781562c25c1c83b5b00c458296bc053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cystoadenofibroma</topic><topic>Magnetic resonance</topic><topic>O-RADS score</topic><topic>Perfusion weighted imaging</topic><topic>Time-intensity curve</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Avesani, Giacomo</creatorcontrib><creatorcontrib>Elia, Lorenzo</creatorcontrib><creatorcontrib>Anghelone, Andrea Giovanni</creatorcontrib><creatorcontrib>Perazzolo, Alessio</creatorcontrib><creatorcontrib>Panico, Camilla</creatorcontrib><creatorcontrib>Di Paola, Valerio</creatorcontrib><creatorcontrib>Gui, Benedetta</creatorcontrib><creatorcontrib>Rodolfino, Elena</creatorcontrib><creatorcontrib>Moro, Francesca</creatorcontrib><creatorcontrib>Testa, Antonia Carla</creatorcontrib><creatorcontrib>Manfredi, Riccardo</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Avesani, Giacomo</au><au>Elia, Lorenzo</au><au>Anghelone, Andrea Giovanni</au><au>Perazzolo, Alessio</au><au>Panico, Camilla</au><au>Di Paola, Valerio</au><au>Gui, Benedetta</au><au>Rodolfino, Elena</au><au>Moro, Francesca</au><au>Testa, Antonia Carla</au><au>Manfredi, Riccardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Features of cystadenofibroma on magnetic resonance imaging: an update using the O-RADS lexicon and considering diffusion-weighted and perfusion imaging</atitle><jtitle>European journal of radiology</jtitle><date>2022-09</date><risdate>2022</risdate><volume>154</volume><spage>110429</spage><epage>110429</epage><pages>110429-110429</pages><artnum>110429</artnum><issn>0720-048X</issn><eissn>1872-7727</eissn><abstract>•Cystoadenofibroma has typical “dark-dark appearance” of the solid component.•On Perfusion Weighted Images, solid tissue shows type I time-intensity curve.•Solid tissue shows no significant restriction in Diffusion Weighted Images.•O-RADS score is able to stratify the risk of malignancy in our entire sample.
Cystadenofibroma (CAF) is a rare tumour of the ovary that can be confused with a borderline or malignant lesion due to its morphological characteristics. The study aims to analyse the MRI (magnetic resonance imaging) features of histologically proven ovarian cystadenofibromas according to lexicon-based and O-RADS (Ovarian-Adnexal Reporting and Data System) descriptors, with particular attention to time-intensity curves (TIC) and Diffusion-Weighted sequences (DWI); we also wanted to test the performance of O-RADS MRI risk stratification system in this particular subgroup of patients.
We have included all patients who performed MR between October 2019 and December 2021 after an inconclusive trans-vaginal ultrasound. All patients underwent surgery with histological results of CAF. According to the O-RADS lexicon, we reported the morphological characteristics of each lesion and their appearance in the perfusion-weighted imaging (PWI) and DWI sequences. We assessed the risk of malignancy for each lesion through O-RADS MRI score.
Twenty-one histologically proven CAF were analysed, of which 20 benign and one borderline with degeneration into adenocarcinoma. We described the typical morphological characteristics of CAF according to lexicon-based and O-RADS descriptors. Analysis of time-intensity curves (TIC) in PWI sequences showed a slow and progressive enhancement of solid tissue (type I curve), configuring an O-RADS score of 2 or 3, except for the only malignant lesion that showed a type II curve and restriction in DWI (O-RADS 4).
Our study is the largest comprising PWI and DWI sequences, highlighting their pivotal role. O-RADS score correctly classified the masses as benign or malignant.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.ejrad.2022.110429</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-1234-003X</orcidid></addata></record> |
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| subjects | Cystoadenofibroma Magnetic resonance O-RADS score Perfusion weighted imaging Time-intensity curve |
| title | Features of cystadenofibroma on magnetic resonance imaging: an update using the O-RADS lexicon and considering diffusion-weighted and perfusion imaging |
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