Quantitative assessment of oculomotor function by videonystagmography in multiple system atrophy
•Extremely high incidence of oculomotor impairments observed using videonystagmography.•Comprehensive oculomotor examination aids in the diagnosis of multiple system atrophy.•Abnormal eye movements detected in the early stages of multiple system atrophy. To quantitatively assess oculomotor impairmen...
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| Veröffentlicht in: | Clinical neurophysiology 2022-09, Vol.141, p.15-23 |
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| creator | Zhou, Hong Sun, Yunchuang Wei, Luhua Wang, Xia Jiang, Yanyan Li, Fan Chen, Jing Sun, Wei Zhang, Lin Zhao, Guiping Wang, Zhaoxia |
| description | •Extremely high incidence of oculomotor impairments observed using videonystagmography.•Comprehensive oculomotor examination aids in the diagnosis of multiple system atrophy.•Abnormal eye movements detected in the early stages of multiple system atrophy.
To quantitatively assess oculomotor impairments in multiple system atrophy (MSA) and to explore their correlation with clinical characteristics.
We recruited 45 patients with MSA, including 21 with dominant ataxia (MSA-C), 24 with dominant parkinsonism (MSA-P), and 40 age-matched healthy controls. Detailed oculomotor performance in the horizontal direction was measured using videonystagmography (VNG).
We found that the proportion of abnormal eye movements in patients with MSA was 93.3% (37.7%, 51.1%, 73.3%, 71.1%, and 37.8% on fixation and gaze-holding, without fixation, saccade, smooth pursuit, and optokinetic nystagmus tests, respectively). Patients with MSA-C showed significantly lower gains in smooth pursuit test and optokinetic nystagmus test, and a higher incidence of hypermetria in the saccade test than patients with MSA-P (all P |
| doi_str_mv | 10.1016/j.clinph.2022.05.019 |
| format | Article |
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To quantitatively assess oculomotor impairments in multiple system atrophy (MSA) and to explore their correlation with clinical characteristics.
We recruited 45 patients with MSA, including 21 with dominant ataxia (MSA-C), 24 with dominant parkinsonism (MSA-P), and 40 age-matched healthy controls. Detailed oculomotor performance in the horizontal direction was measured using videonystagmography (VNG).
We found that the proportion of abnormal eye movements in patients with MSA was 93.3% (37.7%, 51.1%, 73.3%, 71.1%, and 37.8% on fixation and gaze-holding, without fixation, saccade, smooth pursuit, and optokinetic nystagmus tests, respectively). Patients with MSA-C showed significantly lower gains in smooth pursuit test and optokinetic nystagmus test, and a higher incidence of hypermetria in the saccade test than patients with MSA-P (all P < 0.05). No oculomotor deficits were correlated with age, age of onset, sex, disease duration, or Unified Multiple System Atrophy Rating Scale (USMARS) (all r < 0.25, P > 0.1).
An extremely high incidence of oculomotor impairments could be observed using VNG in both the MSA-C and MSA-P subtypes, although there were some differences between them.
A comprehensive oculomotor examination could serve as a valuable tool in the diagnostic workup of patients with MSA.</description><identifier>ISSN: 1388-2457</identifier><identifier>EISSN: 1872-8952</identifier><identifier>DOI: 10.1016/j.clinph.2022.05.019</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Multiple system atrophy ; Oculomotor deficits ; Saccades ; Smooth pursuit movement ; Square-wave jerks ; Videonystagmography</subject><ispartof>Clinical neurophysiology, 2022-09, Vol.141, p.15-23</ispartof><rights>2022 International Federation of Clinical Neurophysiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-5b75ab746fe4e5b6d5d06a5c3916fade968fadf66c48008ccb401cf7516e4a163</citedby><cites>FETCH-LOGICAL-c339t-5b75ab746fe4e5b6d5d06a5c3916fade968fadf66c48008ccb401cf7516e4a163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinph.2022.05.019$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Zhou, Hong</creatorcontrib><creatorcontrib>Sun, Yunchuang</creatorcontrib><creatorcontrib>Wei, Luhua</creatorcontrib><creatorcontrib>Wang, Xia</creatorcontrib><creatorcontrib>Jiang, Yanyan</creatorcontrib><creatorcontrib>Li, Fan</creatorcontrib><creatorcontrib>Chen, Jing</creatorcontrib><creatorcontrib>Sun, Wei</creatorcontrib><creatorcontrib>Zhang, Lin</creatorcontrib><creatorcontrib>Zhao, Guiping</creatorcontrib><creatorcontrib>Wang, Zhaoxia</creatorcontrib><title>Quantitative assessment of oculomotor function by videonystagmography in multiple system atrophy</title><title>Clinical neurophysiology</title><description>•Extremely high incidence of oculomotor impairments observed using videonystagmography.•Comprehensive oculomotor examination aids in the diagnosis of multiple system atrophy.•Abnormal eye movements detected in the early stages of multiple system atrophy.
To quantitatively assess oculomotor impairments in multiple system atrophy (MSA) and to explore their correlation with clinical characteristics.
We recruited 45 patients with MSA, including 21 with dominant ataxia (MSA-C), 24 with dominant parkinsonism (MSA-P), and 40 age-matched healthy controls. Detailed oculomotor performance in the horizontal direction was measured using videonystagmography (VNG).
We found that the proportion of abnormal eye movements in patients with MSA was 93.3% (37.7%, 51.1%, 73.3%, 71.1%, and 37.8% on fixation and gaze-holding, without fixation, saccade, smooth pursuit, and optokinetic nystagmus tests, respectively). Patients with MSA-C showed significantly lower gains in smooth pursuit test and optokinetic nystagmus test, and a higher incidence of hypermetria in the saccade test than patients with MSA-P (all P < 0.05). No oculomotor deficits were correlated with age, age of onset, sex, disease duration, or Unified Multiple System Atrophy Rating Scale (USMARS) (all r < 0.25, P > 0.1).
An extremely high incidence of oculomotor impairments could be observed using VNG in both the MSA-C and MSA-P subtypes, although there were some differences between them.
A comprehensive oculomotor examination could serve as a valuable tool in the diagnostic workup of patients with MSA.</description><subject>Multiple system atrophy</subject><subject>Oculomotor deficits</subject><subject>Saccades</subject><subject>Smooth pursuit movement</subject><subject>Square-wave jerks</subject><subject>Videonystagmography</subject><issn>1388-2457</issn><issn>1872-8952</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKxDAUhosoOI6-gYss3bQmbZOmG0EGbzAggq5jmp7OZGiTmqQDfXsz1LWr_8B_gfMlyS3BGcGE3R8y1Wsz7rMc53mGaYZJfZasCK_ylNc0P493wXmal7S6TK68P2CMK1zmq-T7Y5Im6CCDPgKS3oP3A5iAbIesmno72GAd6iajgrYGNTM66hasmX2Qu8HunBz3M9IGDVMf9NgD8tGCAcngbLSuk4tO9h5u_nSdfD0_fW5e0-37y9vmcZuqoqhDSpuKyqYqWQcl0Ia1tMVMUlXUhHWyhZrxKB1jquQYc6WaEhPVVZQwKCVhxTq5W3ZHZ38m8EEM2ivoe2nATl7kjFcV4ZFDjJZLVDnrvYNOjE4P0s2CYHECKg5iASpOQAWmIgKNtYelBvGNowYnvNJgFLTagQqitfr_gV8GMoRk</recordid><startdate>202209</startdate><enddate>202209</enddate><creator>Zhou, Hong</creator><creator>Sun, Yunchuang</creator><creator>Wei, Luhua</creator><creator>Wang, Xia</creator><creator>Jiang, Yanyan</creator><creator>Li, Fan</creator><creator>Chen, Jing</creator><creator>Sun, Wei</creator><creator>Zhang, Lin</creator><creator>Zhao, Guiping</creator><creator>Wang, Zhaoxia</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202209</creationdate><title>Quantitative assessment of oculomotor function by videonystagmography in multiple system atrophy</title><author>Zhou, Hong ; Sun, Yunchuang ; Wei, Luhua ; Wang, Xia ; Jiang, Yanyan ; Li, Fan ; Chen, Jing ; Sun, Wei ; Zhang, Lin ; Zhao, Guiping ; Wang, Zhaoxia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-5b75ab746fe4e5b6d5d06a5c3916fade968fadf66c48008ccb401cf7516e4a163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Multiple system atrophy</topic><topic>Oculomotor deficits</topic><topic>Saccades</topic><topic>Smooth pursuit movement</topic><topic>Square-wave jerks</topic><topic>Videonystagmography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Hong</creatorcontrib><creatorcontrib>Sun, Yunchuang</creatorcontrib><creatorcontrib>Wei, Luhua</creatorcontrib><creatorcontrib>Wang, Xia</creatorcontrib><creatorcontrib>Jiang, Yanyan</creatorcontrib><creatorcontrib>Li, Fan</creatorcontrib><creatorcontrib>Chen, Jing</creatorcontrib><creatorcontrib>Sun, Wei</creatorcontrib><creatorcontrib>Zhang, Lin</creatorcontrib><creatorcontrib>Zhao, Guiping</creatorcontrib><creatorcontrib>Wang, Zhaoxia</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Hong</au><au>Sun, Yunchuang</au><au>Wei, Luhua</au><au>Wang, Xia</au><au>Jiang, Yanyan</au><au>Li, Fan</au><au>Chen, Jing</au><au>Sun, Wei</au><au>Zhang, Lin</au><au>Zhao, Guiping</au><au>Wang, Zhaoxia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative assessment of oculomotor function by videonystagmography in multiple system atrophy</atitle><jtitle>Clinical neurophysiology</jtitle><date>2022-09</date><risdate>2022</risdate><volume>141</volume><spage>15</spage><epage>23</epage><pages>15-23</pages><issn>1388-2457</issn><eissn>1872-8952</eissn><abstract>•Extremely high incidence of oculomotor impairments observed using videonystagmography.•Comprehensive oculomotor examination aids in the diagnosis of multiple system atrophy.•Abnormal eye movements detected in the early stages of multiple system atrophy.
To quantitatively assess oculomotor impairments in multiple system atrophy (MSA) and to explore their correlation with clinical characteristics.
We recruited 45 patients with MSA, including 21 with dominant ataxia (MSA-C), 24 with dominant parkinsonism (MSA-P), and 40 age-matched healthy controls. Detailed oculomotor performance in the horizontal direction was measured using videonystagmography (VNG).
We found that the proportion of abnormal eye movements in patients with MSA was 93.3% (37.7%, 51.1%, 73.3%, 71.1%, and 37.8% on fixation and gaze-holding, without fixation, saccade, smooth pursuit, and optokinetic nystagmus tests, respectively). Patients with MSA-C showed significantly lower gains in smooth pursuit test and optokinetic nystagmus test, and a higher incidence of hypermetria in the saccade test than patients with MSA-P (all P < 0.05). No oculomotor deficits were correlated with age, age of onset, sex, disease duration, or Unified Multiple System Atrophy Rating Scale (USMARS) (all r < 0.25, P > 0.1).
An extremely high incidence of oculomotor impairments could be observed using VNG in both the MSA-C and MSA-P subtypes, although there were some differences between them.
A comprehensive oculomotor examination could serve as a valuable tool in the diagnostic workup of patients with MSA.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.clinph.2022.05.019</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Multiple system atrophy Oculomotor deficits Saccades Smooth pursuit movement Square-wave jerks Videonystagmography |
| title | Quantitative assessment of oculomotor function by videonystagmography in multiple system atrophy |
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