Overview of Methionine Adenosyltransferase 2A (MAT2A) as an Anticancer Target: Structure, Function, and Inhibitors

Methionine adenosyltransferase 2A (MAT2A) is a rate-limiting enzyme in the methionine cycle that primarily catalyzes the synthesis of S-adenosylmethionine (SAM) from methionine and adenosine triphosphate (ATP). MAT2A has been recognized as a therapeutic target for the treatment of cancers. Recently,...

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Veröffentlicht in:	Journal of medicinal chemistry 2022-07, Vol.65 (14), p.9531-9547
Hauptverfasser:	Li, Chunzheng, Gui, Gang, Zhang, Li, Qin, Anqi, Zhou, Chen, Zha, Xiaoming
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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