Diagnostic utility of PRAME expression by immunohistochemistry in subungual and non‐subungual acral melanocytic lesions
Background The immunohistochemical (IHC) marker PReferentially expressed Antigen in MElanoma (PRAME) has shown promise in the diagnosis of melanocytic lesions. A few studies have investigated PRAME IHC expression in acral melanomas, but PRAME expression in subungual melanomas is largely unknown. We...
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| Veröffentlicht in: | Journal of cutaneous pathology 2022-10, Vol.49 (10), p.859-867 |
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| container_title | Journal of cutaneous pathology |
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| creator | Rothrock, Aimi T. Torres‐Cabala, Carlos A. Milton, Denái R. Cho, Woo Cheal Nagarajan, Priyadharsini Vanderbeck, Kaitlin Curry, Jonathan L. Ivan, Doina Prieto, Victor G. Aung, Phyu P. |
| description | Background
The immunohistochemical (IHC) marker PReferentially expressed Antigen in MElanoma (PRAME) has shown promise in the diagnosis of melanocytic lesions. A few studies have investigated PRAME IHC expression in acral melanomas, but PRAME expression in subungual melanomas is largely unknown. We evaluated the utility of PRAME IHC expression in distinguishing subungual melanomas (SUM) and non‐subungual acral melanomas (AM) from acral nevi (AN).
Methods
Twenty‐two SUM, 20 AM, and 14 AN were identified. IHC studies were performed using an anti‐PRAME antibody. The percentage of lesional cells with PRAME expression was recorded and categorized as follows: 0%, 0; 1%–25%, 1+; 26%–50%, 2+; 51%–75%, 3+; and >75%, 4+. Patient demographics and other relevant clinicopathologic parameters were recorded.
Results
Diffuse (4+) PRAME IHC expression was identified in 55% (12/22) SUM and 70% (14/20) AM, respectively. Any PRAME expression (1+ to 4+) was identified in 73% (16/22) SUMs and 95% (19/20) AM, respectively. One of 14 (7%) AN exhibited PRAME expression; interestingly, the pattern of expression was diffuse.
Conclusions
In our study, PRAME IHC expression was useful in identifying AM, including SUM. However, there are exceptions of PRAME‐negative melanomas and PRAME‐positive nevi. |
| doi_str_mv | 10.1111/cup.14290 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2686058276</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2686058276</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4190-fca125cb21f550712765192fcb80a56484fc38e544e0c95f7288c9d2485372a03</originalsourceid><addsrcrecordid>eNp1kc1qFTEYhoO02GN10RsogW50Me2Xv5nMshyPWmixiF2HTE6mTZlJjskEnZ2X4DV6JeZ42lIEs8gHHw9PXvIidETglJRzZvLmlHDawgu0IDVABaKGPbQABqyqW9kcoFcp3QOQWtbiJTpgoml5zdkCze-dvvUhTc7gPLnBTTMOPb7-cn61wvbHJtqUXPC4m7Ebx-zDnUtTMHd2LDOWpccpd9nfZj1g7dfYB__7569nOxPLPdpB-2Dm7TOD3RrTa7Tf6yHZNw_zEN18WH1dfqouP3-8WJ5fVoaTFqreaEKF6SjphYCG0KYWpKW96SRoUXPJe8OkFZxbMK3oGyqladeUS8EaqoEdorc77yaGb9mmSZXoxg4lkA05KVr-BIQs3oKe_IPehxx9SadoQwTjTNCt8N2OMjGkFG2vNtGNOs6KgNr2oUof6m8fhT1-MOZutOsn8rGAApztgO9usPP_TWp5c71T_gF8HZZC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2715343520</pqid></control><display><type>article</type><title>Diagnostic utility of PRAME expression by immunohistochemistry in subungual and non‐subungual acral melanocytic lesions</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Rothrock, Aimi T. ; Torres‐Cabala, Carlos A. ; Milton, Denái R. ; Cho, Woo Cheal ; Nagarajan, Priyadharsini ; Vanderbeck, Kaitlin ; Curry, Jonathan L. ; Ivan, Doina ; Prieto, Victor G. ; Aung, Phyu P.</creator><creatorcontrib>Rothrock, Aimi T. ; Torres‐Cabala, Carlos A. ; Milton, Denái R. ; Cho, Woo Cheal ; Nagarajan, Priyadharsini ; Vanderbeck, Kaitlin ; Curry, Jonathan L. ; Ivan, Doina ; Prieto, Victor G. ; Aung, Phyu P.</creatorcontrib><description>Background
The immunohistochemical (IHC) marker PReferentially expressed Antigen in MElanoma (PRAME) has shown promise in the diagnosis of melanocytic lesions. A few studies have investigated PRAME IHC expression in acral melanomas, but PRAME expression in subungual melanomas is largely unknown. We evaluated the utility of PRAME IHC expression in distinguishing subungual melanomas (SUM) and non‐subungual acral melanomas (AM) from acral nevi (AN).
Methods
Twenty‐two SUM, 20 AM, and 14 AN were identified. IHC studies were performed using an anti‐PRAME antibody. The percentage of lesional cells with PRAME expression was recorded and categorized as follows: 0%, 0; 1%–25%, 1+; 26%–50%, 2+; 51%–75%, 3+; and >75%, 4+. Patient demographics and other relevant clinicopathologic parameters were recorded.
Results
Diffuse (4+) PRAME IHC expression was identified in 55% (12/22) SUM and 70% (14/20) AM, respectively. Any PRAME expression (1+ to 4+) was identified in 73% (16/22) SUMs and 95% (19/20) AM, respectively. One of 14 (7%) AN exhibited PRAME expression; interestingly, the pattern of expression was diffuse.
Conclusions
In our study, PRAME IHC expression was useful in identifying AM, including SUM. However, there are exceptions of PRAME‐negative melanomas and PRAME‐positive nevi.</description><identifier>ISSN: 0303-6987</identifier><identifier>EISSN: 1600-0560</identifier><identifier>DOI: 10.1111/cup.14290</identifier><identifier>PMID: 35794643</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>acral ; Antigens, Neoplasm ; Humans ; Immunohistochemistry ; Melanoma ; Melanoma - pathology ; Melanoma, Cutaneous Malignant ; Nail Diseases - diagnosis ; nevus ; Nevus - pathology ; Nevus, Epithelioid and Spindle Cell ; PRAME ; Skin Neoplasms - pathology ; subungual</subject><ispartof>Journal of cutaneous pathology, 2022-10, Vol.49 (10), p.859-867</ispartof><rights>2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4190-fca125cb21f550712765192fcb80a56484fc38e544e0c95f7288c9d2485372a03</citedby><cites>FETCH-LOGICAL-c4190-fca125cb21f550712765192fcb80a56484fc38e544e0c95f7288c9d2485372a03</cites><orcidid>0000-0001-5867-1403 ; 0000-0002-3398-0573 ; 0000-0002-5346-2669 ; 0000-0002-4703-7009</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcup.14290$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcup.14290$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35794643$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rothrock, Aimi T.</creatorcontrib><creatorcontrib>Torres‐Cabala, Carlos A.</creatorcontrib><creatorcontrib>Milton, Denái R.</creatorcontrib><creatorcontrib>Cho, Woo Cheal</creatorcontrib><creatorcontrib>Nagarajan, Priyadharsini</creatorcontrib><creatorcontrib>Vanderbeck, Kaitlin</creatorcontrib><creatorcontrib>Curry, Jonathan L.</creatorcontrib><creatorcontrib>Ivan, Doina</creatorcontrib><creatorcontrib>Prieto, Victor G.</creatorcontrib><creatorcontrib>Aung, Phyu P.</creatorcontrib><title>Diagnostic utility of PRAME expression by immunohistochemistry in subungual and non‐subungual acral melanocytic lesions</title><title>Journal of cutaneous pathology</title><addtitle>J Cutan Pathol</addtitle><description>Background
The immunohistochemical (IHC) marker PReferentially expressed Antigen in MElanoma (PRAME) has shown promise in the diagnosis of melanocytic lesions. A few studies have investigated PRAME IHC expression in acral melanomas, but PRAME expression in subungual melanomas is largely unknown. We evaluated the utility of PRAME IHC expression in distinguishing subungual melanomas (SUM) and non‐subungual acral melanomas (AM) from acral nevi (AN).
Methods
Twenty‐two SUM, 20 AM, and 14 AN were identified. IHC studies were performed using an anti‐PRAME antibody. The percentage of lesional cells with PRAME expression was recorded and categorized as follows: 0%, 0; 1%–25%, 1+; 26%–50%, 2+; 51%–75%, 3+; and >75%, 4+. Patient demographics and other relevant clinicopathologic parameters were recorded.
Results
Diffuse (4+) PRAME IHC expression was identified in 55% (12/22) SUM and 70% (14/20) AM, respectively. Any PRAME expression (1+ to 4+) was identified in 73% (16/22) SUMs and 95% (19/20) AM, respectively. One of 14 (7%) AN exhibited PRAME expression; interestingly, the pattern of expression was diffuse.
Conclusions
In our study, PRAME IHC expression was useful in identifying AM, including SUM. However, there are exceptions of PRAME‐negative melanomas and PRAME‐positive nevi.</description><subject>acral</subject><subject>Antigens, Neoplasm</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Melanoma</subject><subject>Melanoma - pathology</subject><subject>Melanoma, Cutaneous Malignant</subject><subject>Nail Diseases - diagnosis</subject><subject>nevus</subject><subject>Nevus - pathology</subject><subject>Nevus, Epithelioid and Spindle Cell</subject><subject>PRAME</subject><subject>Skin Neoplasms - pathology</subject><subject>subungual</subject><issn>0303-6987</issn><issn>1600-0560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1qFTEYhoO02GN10RsogW50Me2Xv5nMshyPWmixiF2HTE6mTZlJjskEnZ2X4DV6JeZ42lIEs8gHHw9PXvIidETglJRzZvLmlHDawgu0IDVABaKGPbQABqyqW9kcoFcp3QOQWtbiJTpgoml5zdkCze-dvvUhTc7gPLnBTTMOPb7-cn61wvbHJtqUXPC4m7Ebx-zDnUtTMHd2LDOWpccpd9nfZj1g7dfYB__7569nOxPLPdpB-2Dm7TOD3RrTa7Tf6yHZNw_zEN18WH1dfqouP3-8WJ5fVoaTFqreaEKF6SjphYCG0KYWpKW96SRoUXPJe8OkFZxbMK3oGyqladeUS8EaqoEdorc77yaGb9mmSZXoxg4lkA05KVr-BIQs3oKe_IPehxx9SadoQwTjTNCt8N2OMjGkFG2vNtGNOs6KgNr2oUof6m8fhT1-MOZutOsn8rGAApztgO9usPP_TWp5c71T_gF8HZZC</recordid><startdate>202210</startdate><enddate>202210</enddate><creator>Rothrock, Aimi T.</creator><creator>Torres‐Cabala, Carlos A.</creator><creator>Milton, Denái R.</creator><creator>Cho, Woo Cheal</creator><creator>Nagarajan, Priyadharsini</creator><creator>Vanderbeck, Kaitlin</creator><creator>Curry, Jonathan L.</creator><creator>Ivan, Doina</creator><creator>Prieto, Victor G.</creator><creator>Aung, Phyu P.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5867-1403</orcidid><orcidid>https://orcid.org/0000-0002-3398-0573</orcidid><orcidid>https://orcid.org/0000-0002-5346-2669</orcidid><orcidid>https://orcid.org/0000-0002-4703-7009</orcidid></search><sort><creationdate>202210</creationdate><title>Diagnostic utility of PRAME expression by immunohistochemistry in subungual and non‐subungual acral melanocytic lesions</title><author>Rothrock, Aimi T. ; Torres‐Cabala, Carlos A. ; Milton, Denái R. ; Cho, Woo Cheal ; Nagarajan, Priyadharsini ; Vanderbeck, Kaitlin ; Curry, Jonathan L. ; Ivan, Doina ; Prieto, Victor G. ; Aung, Phyu P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4190-fca125cb21f550712765192fcb80a56484fc38e544e0c95f7288c9d2485372a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>acral</topic><topic>Antigens, Neoplasm</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Melanoma</topic><topic>Melanoma - pathology</topic><topic>Melanoma, Cutaneous Malignant</topic><topic>Nail Diseases - diagnosis</topic><topic>nevus</topic><topic>Nevus - pathology</topic><topic>Nevus, Epithelioid and Spindle Cell</topic><topic>PRAME</topic><topic>Skin Neoplasms - pathology</topic><topic>subungual</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rothrock, Aimi T.</creatorcontrib><creatorcontrib>Torres‐Cabala, Carlos A.</creatorcontrib><creatorcontrib>Milton, Denái R.</creatorcontrib><creatorcontrib>Cho, Woo Cheal</creatorcontrib><creatorcontrib>Nagarajan, Priyadharsini</creatorcontrib><creatorcontrib>Vanderbeck, Kaitlin</creatorcontrib><creatorcontrib>Curry, Jonathan L.</creatorcontrib><creatorcontrib>Ivan, Doina</creatorcontrib><creatorcontrib>Prieto, Victor G.</creatorcontrib><creatorcontrib>Aung, Phyu P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cutaneous pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rothrock, Aimi T.</au><au>Torres‐Cabala, Carlos A.</au><au>Milton, Denái R.</au><au>Cho, Woo Cheal</au><au>Nagarajan, Priyadharsini</au><au>Vanderbeck, Kaitlin</au><au>Curry, Jonathan L.</au><au>Ivan, Doina</au><au>Prieto, Victor G.</au><au>Aung, Phyu P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic utility of PRAME expression by immunohistochemistry in subungual and non‐subungual acral melanocytic lesions</atitle><jtitle>Journal of cutaneous pathology</jtitle><addtitle>J Cutan Pathol</addtitle><date>2022-10</date><risdate>2022</risdate><volume>49</volume><issue>10</issue><spage>859</spage><epage>867</epage><pages>859-867</pages><issn>0303-6987</issn><eissn>1600-0560</eissn><abstract>Background
The immunohistochemical (IHC) marker PReferentially expressed Antigen in MElanoma (PRAME) has shown promise in the diagnosis of melanocytic lesions. A few studies have investigated PRAME IHC expression in acral melanomas, but PRAME expression in subungual melanomas is largely unknown. We evaluated the utility of PRAME IHC expression in distinguishing subungual melanomas (SUM) and non‐subungual acral melanomas (AM) from acral nevi (AN).
Methods
Twenty‐two SUM, 20 AM, and 14 AN were identified. IHC studies were performed using an anti‐PRAME antibody. The percentage of lesional cells with PRAME expression was recorded and categorized as follows: 0%, 0; 1%–25%, 1+; 26%–50%, 2+; 51%–75%, 3+; and >75%, 4+. Patient demographics and other relevant clinicopathologic parameters were recorded.
Results
Diffuse (4+) PRAME IHC expression was identified in 55% (12/22) SUM and 70% (14/20) AM, respectively. Any PRAME expression (1+ to 4+) was identified in 73% (16/22) SUMs and 95% (19/20) AM, respectively. One of 14 (7%) AN exhibited PRAME expression; interestingly, the pattern of expression was diffuse.
Conclusions
In our study, PRAME IHC expression was useful in identifying AM, including SUM. However, there are exceptions of PRAME‐negative melanomas and PRAME‐positive nevi.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>35794643</pmid><doi>10.1111/cup.14290</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5867-1403</orcidid><orcidid>https://orcid.org/0000-0002-3398-0573</orcidid><orcidid>https://orcid.org/0000-0002-5346-2669</orcidid><orcidid>https://orcid.org/0000-0002-4703-7009</orcidid></addata></record> |
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| ispartof | Journal of cutaneous pathology, 2022-10, Vol.49 (10), p.859-867 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | acral Antigens, Neoplasm Humans Immunohistochemistry Melanoma Melanoma - pathology Melanoma, Cutaneous Malignant Nail Diseases - diagnosis nevus Nevus - pathology Nevus, Epithelioid and Spindle Cell PRAME Skin Neoplasms - pathology subungual |
| title | Diagnostic utility of PRAME expression by immunohistochemistry in subungual and non‐subungual acral melanocytic lesions |
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