C. elegans as a model for inter-individual variation in metabolism

Individuals can exhibit differences in metabolism that are caused by the interplay of genetic background, nutritional input, microbiota and other environmental factors 1 – 4 . It is difficult to connect differences in metabolism to genomic variation and derive underlying molecular mechanisms in huma...

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Veröffentlicht in:	Nature (London) 2022-07, Vol.607 (7919), p.571-577
Hauptverfasser:	Fox, Bennett W., Ponomarova, Olga, Lee, Yong-Uk, Zhang, Gaotian, Giese, Gabrielle E., Walker, Melissa, Roberto, Nicole M., Na, Huimin, Rodrigues, Pedro R., Curtis, Brian J., Kolodziej, Aiden R., Crombie, Timothy A., Zdraljevic, Stefan, Yilmaz, L. Safak, Andersen, Erik C., Schroeder, Frank C., Walhout, Albertha J. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	38/39 38/70 38/91 631/208/727 631/443/319/320 631/92/1643 64 64/11 Alcohol Oxidoreductases - genetics Alcohol Oxidoreductases - metabolism Amino acids Amino Acids - metabolism Animals Caenorhabditis elegans - classification Caenorhabditis elegans - enzymology Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Carbohydrates Chromatography Diet E coli Fatty acids Gene expression Genetic diversity Genomes Humanities and Social Sciences Humans Lactic Acid - analogs & derivatives Lactic Acid - metabolism Mass spectrometry Medical screening Metabolic networks Metabolic Networks and Pathways - genetics Metabolism Metabolites Microbiota Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Models, Animal Molecular modelling multidisciplinary Mutation Nematodes Propionates - metabolism Propionic acid Science Science (multidisciplinary) Scientific imaging Shunts Substrates Vitamin B 12 - metabolism
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