Red Blood Cell Inspired Strategies for Drug Delivery: Emerging Concepts and New Advances
In the past five decades, red blood cells (RBCs) have been extensively explored as drug delivery systems due to their distinguishing potential in modulating the pharmacokinetic, pharmacodynamics, and biological activity of carried payloads. The extensive interests in RBC-mediated drug delivery techn...
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| Veröffentlicht in: | Pharmaceutical research 2022-11, Vol.39 (11), p.2673-2698 |
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| creator | Zhang, Endong Phan, Philana Algarni, Hanan Ahmed Zhao, Zongmin |
| description | In the past five decades, red blood cells (RBCs) have been extensively explored as drug delivery systems due to their distinguishing potential in modulating the pharmacokinetic, pharmacodynamics, and biological activity of carried payloads. The extensive interests in RBC-mediated drug delivery technologies are in part derived from RBCs’ unique biological features such as long circulation time, wide access to many tissues in the body, and low immunogenicity. Owing to these outstanding properties, a large body of efforts have led to the development of various RBC-inspired strategies to enable precise drug delivery with enhanced therapeutic efficacy and reduced off-target toxicity. In this review, we discuss emerging concepts and new advances in such RBC-inspired strategies, including native RBCs, ghost RBCs, RBC-mimetic nanoparticles, and RBC-derived extracellular vesicles, for drug delivery. |
| doi_str_mv | 10.1007/s11095-022-03328-5 |
| format | Article |
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| subjects | B cells Biochemistry Biological activity Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Blood Drug delivery Drug delivery systems Drugs Emerging Leaders in Pharmaceutical and Biomedical Sciences Enzymes Erythrocytes Extracellular vesicles Health aspects Immunogenicity Medical Law Nanoparticles Pharmaceuticals Pharmacodynamics Pharmacokinetics Pharmacology/Toxicology Pharmacy Review Article Toxicity Vehicles |
| title | Red Blood Cell Inspired Strategies for Drug Delivery: Emerging Concepts and New Advances |
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