Berberine-mediated REDD1 down-regulation ameliorates senescence of retinal pigment epithelium by interrupting the ROS-DDR positive feedback loop

Accumulation of age-associated senescent cells accompanied with increased reactive oxygen species (ROS) and inflammatory factors contributes to the progression of age-related macular degeneration (AMD), the main cause of blindness in the elderly. Berberine (BBR) has shown efficacy in the treatment o...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2022-09, Vol.104, p.154181-154181, Article 154181
Hauptverfasser:	Chen, Qingqiu, Xin, Guang, Li, Shiyi, Dong, Yuman, Yu, Xiuxian, Wan, Chengyu, Wei, Zeliang, Zhu, Yuda, Zhang, Kun, Wang, Yilan, Li, Fan, Zhang, Cuicui, Wen, E, Li, Yulong, Niu, Hai, Huang, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	autophagic flux Berberine REDD1 retinal pigment epithelium senescence
Online-Zugang:	Volltext
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