First morning voided urinary gonadotropins in children: verification of method performance and establishment of reference intervals
Urinary luteinizing hormone (uLH) and urinary follicle-stimulating hormone (uFSH) have been shown to be useful screening and management tools for children with central precocious puberty. However, studies on uLH and uFSH reference intervals are scarce. Therefore, we aimed to establish reference inte...
Gespeichert in:
| Veröffentlicht in: | Clinical chemistry and laboratory medicine 2022-08, Vol.60 (9), p.1416-1425 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1425 |
|---|---|
| container_issue | 9 |
| container_start_page | 1416 |
| container_title | Clinical chemistry and laboratory medicine |
| container_volume | 60 |
| creator | Yao, Yifan Mao, Shunfeng Yuan, Ke He, Minfei Dong, Minya Huang, Yandi Yang, Donglei Zhang, Xiaoyan Peng, Chen Zhu, Yilin Wang, Chunlin |
| description | Urinary luteinizing hormone (uLH) and urinary follicle-stimulating hormone (uFSH) have been shown to be useful screening and management tools for children with central precocious puberty. However, studies on uLH and uFSH reference intervals are scarce. Therefore, we aimed to establish reference intervals for uLH and uFSH, according to age, sex, and pubertal status in apparently healthy children aged 6–11 years.We performed detection capability, precision, accuracy by recovery, linearity, agreement analysis, and stability testing to analyze the method performance of uLH and uFSH. The Clinical Laboratory Standards Institute’s C28-A3 criteria was used to establish the reference intervals.Both uLH and uFSH were stable at 4 °C for 52.6 h and 64.8 days, respectively. The total imprecision of uFSH is within the manufacturer’s claim, while the total imprecision of uLH remained within tolerable bias. Both uLH and uFSH could be measured with acceptable detection capability. The recovery rates of the hormones were 87.6–98.8% and 102.8–103.4%, respectively, and therefore within acceptable limits. There were significant correlations between the serum and urine concentrations (LH: r=0.91, p |
| doi_str_mv | 10.1515/cclm-2022-0296 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2685040646</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2697160271</sourcerecordid><originalsourceid>FETCH-LOGICAL-c354t-edea7713594a3fae73aff6f10ebd50c6fe6c0b48a9ece7c53a984479530316c63</originalsourceid><addsrcrecordid>eNptkUtLAzEUhYMoqNWt64AbN1OTyWM6ggsRXyC40fWQJjdtykxSk5lK1_5xM1YQxNW9kO8czs1B6IySKRVUXGrddkVJyrIgZS330BHlrCo4Y3T_e-eFlCU9RMcprQihQvDqCH3eu5h63IXonV_gTXAGDB6i8ypu8SJ4ZUIfw9r5hJ3HeulaE8Ff4Q1EZ51WvQseB4s76JfB4DVEG2KnvAasvMGQejVvXVp24PuRi2AhG-Rn53uIG9WmE3Rg84DTnzlBb_d3r7ePxfPLw9PtzXOhmeB9AQZUVVEmaq6YVVAxZa20lMDcCKKlBanJnM9UDRoqLZiqZ5xXtWCEUaklm6CLne86hvchJ2s6lzS0rfIQhtSUciYIJ5KP6PkfdBWG6HO6TNUVlaTMSSZouqN0DCnly5p1dF3-uIaSZuykGTtpxk6asZMsuN4JPlSbjzewiMM2L7_u_wslqSmnkn0B2FCXFA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2697160271</pqid></control><display><type>article</type><title>First morning voided urinary gonadotropins in children: verification of method performance and establishment of reference intervals</title><source>De Gruyter journals</source><creator>Yao, Yifan ; Mao, Shunfeng ; Yuan, Ke ; He, Minfei ; Dong, Minya ; Huang, Yandi ; Yang, Donglei ; Zhang, Xiaoyan ; Peng, Chen ; Zhu, Yilin ; Wang, Chunlin</creator><creatorcontrib>Yao, Yifan ; Mao, Shunfeng ; Yuan, Ke ; He, Minfei ; Dong, Minya ; Huang, Yandi ; Yang, Donglei ; Zhang, Xiaoyan ; Peng, Chen ; Zhu, Yilin ; Wang, Chunlin</creatorcontrib><description>Urinary luteinizing hormone (uLH) and urinary follicle-stimulating hormone (uFSH) have been shown to be useful screening and management tools for children with central precocious puberty. However, studies on uLH and uFSH reference intervals are scarce. Therefore, we aimed to establish reference intervals for uLH and uFSH, according to age, sex, and pubertal status in apparently healthy children aged 6–11 years.We performed detection capability, precision, accuracy by recovery, linearity, agreement analysis, and stability testing to analyze the method performance of uLH and uFSH. The Clinical Laboratory Standards Institute’s C28-A3 criteria was used to establish the reference intervals.Both uLH and uFSH were stable at 4 °C for 52.6 h and 64.8 days, respectively. The total imprecision of uFSH is within the manufacturer’s claim, while the total imprecision of uLH remained within tolerable bias. Both uLH and uFSH could be measured with acceptable detection capability. The recovery rates of the hormones were 87.6–98.8% and 102.8–103.4%, respectively, and therefore within acceptable limits. There were significant correlations between the serum and urine concentrations (LH: r=0.91, p<0.001; FSH: r=0.90, p<0.001). The reference intervals of uLH and uFSH were established according to age, sex, and pubertal status.We established reference intervals for uLH and uFSH based on age, sex and pubertal status to provide a non-invasive clinical screening tool for precocious puberty in children aged 6–11 years.</description><identifier>ISSN: 1434-6621</identifier><identifier>EISSN: 1437-4331</identifier><identifier>DOI: 10.1515/cclm-2022-0296</identifier><language>eng</language><publisher>Berlin: De Gruyter</publisher><subject>Age ; Children ; Follicle-stimulating hormone ; Gonadotropins ; Hormones ; Intervals ; Luteinizing hormone ; Management tools ; Pituitary (anterior) ; precocious puberty ; Puberty ; Recovery ; reference interval ; Sex ; Stability analysis</subject><ispartof>Clinical chemistry and laboratory medicine, 2022-08, Vol.60 (9), p.1416-1425</ispartof><rights>2022 Walter de Gruyter GmbH, Berlin/Boston</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-edea7713594a3fae73aff6f10ebd50c6fe6c0b48a9ece7c53a984479530316c63</citedby><cites>FETCH-LOGICAL-c354t-edea7713594a3fae73aff6f10ebd50c6fe6c0b48a9ece7c53a984479530316c63</cites><orcidid>0000-0003-0641-1364 ; 0000-0003-3821-3047</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.degruyter.com/document/doi/10.1515/cclm-2022-0296/pdf$$EPDF$$P50$$Gwalterdegruyter$$H</linktopdf><linktohtml>$$Uhttps://www.degruyter.com/document/doi/10.1515/cclm-2022-0296/html$$EHTML$$P50$$Gwalterdegruyter$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,66505,68289</link.rule.ids></links><search><creatorcontrib>Yao, Yifan</creatorcontrib><creatorcontrib>Mao, Shunfeng</creatorcontrib><creatorcontrib>Yuan, Ke</creatorcontrib><creatorcontrib>He, Minfei</creatorcontrib><creatorcontrib>Dong, Minya</creatorcontrib><creatorcontrib>Huang, Yandi</creatorcontrib><creatorcontrib>Yang, Donglei</creatorcontrib><creatorcontrib>Zhang, Xiaoyan</creatorcontrib><creatorcontrib>Peng, Chen</creatorcontrib><creatorcontrib>Zhu, Yilin</creatorcontrib><creatorcontrib>Wang, Chunlin</creatorcontrib><title>First morning voided urinary gonadotropins in children: verification of method performance and establishment of reference intervals</title><title>Clinical chemistry and laboratory medicine</title><description>Urinary luteinizing hormone (uLH) and urinary follicle-stimulating hormone (uFSH) have been shown to be useful screening and management tools for children with central precocious puberty. However, studies on uLH and uFSH reference intervals are scarce. Therefore, we aimed to establish reference intervals for uLH and uFSH, according to age, sex, and pubertal status in apparently healthy children aged 6–11 years.We performed detection capability, precision, accuracy by recovery, linearity, agreement analysis, and stability testing to analyze the method performance of uLH and uFSH. The Clinical Laboratory Standards Institute’s C28-A3 criteria was used to establish the reference intervals.Both uLH and uFSH were stable at 4 °C for 52.6 h and 64.8 days, respectively. The total imprecision of uFSH is within the manufacturer’s claim, while the total imprecision of uLH remained within tolerable bias. Both uLH and uFSH could be measured with acceptable detection capability. The recovery rates of the hormones were 87.6–98.8% and 102.8–103.4%, respectively, and therefore within acceptable limits. There were significant correlations between the serum and urine concentrations (LH: r=0.91, p<0.001; FSH: r=0.90, p<0.001). The reference intervals of uLH and uFSH were established according to age, sex, and pubertal status.We established reference intervals for uLH and uFSH based on age, sex and pubertal status to provide a non-invasive clinical screening tool for precocious puberty in children aged 6–11 years.</description><subject>Age</subject><subject>Children</subject><subject>Follicle-stimulating hormone</subject><subject>Gonadotropins</subject><subject>Hormones</subject><subject>Intervals</subject><subject>Luteinizing hormone</subject><subject>Management tools</subject><subject>Pituitary (anterior)</subject><subject>precocious puberty</subject><subject>Puberty</subject><subject>Recovery</subject><subject>reference interval</subject><subject>Sex</subject><subject>Stability analysis</subject><issn>1434-6621</issn><issn>1437-4331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNptkUtLAzEUhYMoqNWt64AbN1OTyWM6ggsRXyC40fWQJjdtykxSk5lK1_5xM1YQxNW9kO8czs1B6IySKRVUXGrddkVJyrIgZS330BHlrCo4Y3T_e-eFlCU9RMcprQihQvDqCH3eu5h63IXonV_gTXAGDB6i8ypu8SJ4ZUIfw9r5hJ3HeulaE8Ff4Q1EZ51WvQseB4s76JfB4DVEG2KnvAasvMGQejVvXVp24PuRi2AhG-Rn53uIG9WmE3Rg84DTnzlBb_d3r7ePxfPLw9PtzXOhmeB9AQZUVVEmaq6YVVAxZa20lMDcCKKlBanJnM9UDRoqLZiqZ5xXtWCEUaklm6CLne86hvchJ2s6lzS0rfIQhtSUciYIJ5KP6PkfdBWG6HO6TNUVlaTMSSZouqN0DCnly5p1dF3-uIaSZuykGTtpxk6asZMsuN4JPlSbjzewiMM2L7_u_wslqSmnkn0B2FCXFA</recordid><startdate>20220826</startdate><enddate>20220826</enddate><creator>Yao, Yifan</creator><creator>Mao, Shunfeng</creator><creator>Yuan, Ke</creator><creator>He, Minfei</creator><creator>Dong, Minya</creator><creator>Huang, Yandi</creator><creator>Yang, Donglei</creator><creator>Zhang, Xiaoyan</creator><creator>Peng, Chen</creator><creator>Zhu, Yilin</creator><creator>Wang, Chunlin</creator><general>De Gruyter</general><general>Walter De Gruyter & Company</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0641-1364</orcidid><orcidid>https://orcid.org/0000-0003-3821-3047</orcidid></search><sort><creationdate>20220826</creationdate><title>First morning voided urinary gonadotropins in children: verification of method performance and establishment of reference intervals</title><author>Yao, Yifan ; Mao, Shunfeng ; Yuan, Ke ; He, Minfei ; Dong, Minya ; Huang, Yandi ; Yang, Donglei ; Zhang, Xiaoyan ; Peng, Chen ; Zhu, Yilin ; Wang, Chunlin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-edea7713594a3fae73aff6f10ebd50c6fe6c0b48a9ece7c53a984479530316c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Age</topic><topic>Children</topic><topic>Follicle-stimulating hormone</topic><topic>Gonadotropins</topic><topic>Hormones</topic><topic>Intervals</topic><topic>Luteinizing hormone</topic><topic>Management tools</topic><topic>Pituitary (anterior)</topic><topic>precocious puberty</topic><topic>Puberty</topic><topic>Recovery</topic><topic>reference interval</topic><topic>Sex</topic><topic>Stability analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yao, Yifan</creatorcontrib><creatorcontrib>Mao, Shunfeng</creatorcontrib><creatorcontrib>Yuan, Ke</creatorcontrib><creatorcontrib>He, Minfei</creatorcontrib><creatorcontrib>Dong, Minya</creatorcontrib><creatorcontrib>Huang, Yandi</creatorcontrib><creatorcontrib>Yang, Donglei</creatorcontrib><creatorcontrib>Zhang, Xiaoyan</creatorcontrib><creatorcontrib>Peng, Chen</creatorcontrib><creatorcontrib>Zhu, Yilin</creatorcontrib><creatorcontrib>Wang, Chunlin</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical chemistry and laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yao, Yifan</au><au>Mao, Shunfeng</au><au>Yuan, Ke</au><au>He, Minfei</au><au>Dong, Minya</au><au>Huang, Yandi</au><au>Yang, Donglei</au><au>Zhang, Xiaoyan</au><au>Peng, Chen</au><au>Zhu, Yilin</au><au>Wang, Chunlin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First morning voided urinary gonadotropins in children: verification of method performance and establishment of reference intervals</atitle><jtitle>Clinical chemistry and laboratory medicine</jtitle><date>2022-08-26</date><risdate>2022</risdate><volume>60</volume><issue>9</issue><spage>1416</spage><epage>1425</epage><pages>1416-1425</pages><issn>1434-6621</issn><eissn>1437-4331</eissn><abstract>Urinary luteinizing hormone (uLH) and urinary follicle-stimulating hormone (uFSH) have been shown to be useful screening and management tools for children with central precocious puberty. However, studies on uLH and uFSH reference intervals are scarce. Therefore, we aimed to establish reference intervals for uLH and uFSH, according to age, sex, and pubertal status in apparently healthy children aged 6–11 years.We performed detection capability, precision, accuracy by recovery, linearity, agreement analysis, and stability testing to analyze the method performance of uLH and uFSH. The Clinical Laboratory Standards Institute’s C28-A3 criteria was used to establish the reference intervals.Both uLH and uFSH were stable at 4 °C for 52.6 h and 64.8 days, respectively. The total imprecision of uFSH is within the manufacturer’s claim, while the total imprecision of uLH remained within tolerable bias. Both uLH and uFSH could be measured with acceptable detection capability. The recovery rates of the hormones were 87.6–98.8% and 102.8–103.4%, respectively, and therefore within acceptable limits. There were significant correlations between the serum and urine concentrations (LH: r=0.91, p<0.001; FSH: r=0.90, p<0.001). The reference intervals of uLH and uFSH were established according to age, sex, and pubertal status.We established reference intervals for uLH and uFSH based on age, sex and pubertal status to provide a non-invasive clinical screening tool for precocious puberty in children aged 6–11 years.</abstract><cop>Berlin</cop><pub>De Gruyter</pub><doi>10.1515/cclm-2022-0296</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0641-1364</orcidid><orcidid>https://orcid.org/0000-0003-3821-3047</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1434-6621 |
| ispartof | Clinical chemistry and laboratory medicine, 2022-08, Vol.60 (9), p.1416-1425 |
| issn | 1434-6621 1437-4331 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2685040646 |
| source | De Gruyter journals |
| subjects | Age Children Follicle-stimulating hormone Gonadotropins Hormones Intervals Luteinizing hormone Management tools Pituitary (anterior) precocious puberty Puberty Recovery reference interval Sex Stability analysis |
| title | First morning voided urinary gonadotropins in children: verification of method performance and establishment of reference intervals |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T02%3A13%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=First%20morning%20voided%20urinary%20gonadotropins%20in%20children:%20verification%20of%20method%20performance%20and%20establishment%20of%20reference%20intervals&rft.jtitle=Clinical%20chemistry%20and%20laboratory%20medicine&rft.au=Yao,%20Yifan&rft.date=2022-08-26&rft.volume=60&rft.issue=9&rft.spage=1416&rft.epage=1425&rft.pages=1416-1425&rft.issn=1434-6621&rft.eissn=1437-4331&rft_id=info:doi/10.1515/cclm-2022-0296&rft_dat=%3Cproquest_cross%3E2697160271%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2697160271&rft_id=info:pmid/&rfr_iscdi=true |