Ameliorating potential of curcumin and its analogue in central nervous system disorders and related conditions: A review of molecular pathways
Curcumin, isolated from turmeric (Curcuma longa L.) is one of the broadly studied phytomolecule owing to its strong antioxidant and anti‐inflammatory potential and has been considered a promising therapeutic candidate in a wide range of disorders. Considering, its low bioavailability, different curc...
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| Veröffentlicht in: | Phytotherapy research 2022-08, Vol.36 (8), p.3143-3180 |
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| container_title | Phytotherapy research |
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| creator | Joshi, Priyanka Bisht, Akansha Joshi, Sushil Semwal, Deepak Nema, Neelesh Kumar Dwivedi, Jaya Sharma, Swapnil |
| description | Curcumin, isolated from turmeric (Curcuma longa L.) is one of the broadly studied phytomolecule owing to its strong antioxidant and anti‐inflammatory potential and has been considered a promising therapeutic candidate in a wide range of disorders. Considering, its low bioavailability, different curcumin analogs have been developed to afford desired pharmacokinetic profile and therapeutic outcome in varied pathological states. Several preclinical and clinical studies have indicated that curcumin ameliorates mitochondrial dysfunction, inflammation, oxidative stress apoptosis‐mediated neural cell degeneration and could effectively be utilized in the treatment of different neurodegenerative diseases. Hence, in this review, we have summarized key findings of experimental and clinical studies conducted on curcumin and its analogues with special emphasis on molecular pathways, viz. NF‐kB, Nrf2‐ARE, glial activation, apoptosis, angiogenesis, SOCS/JAK/STAT, PI3K/Akt, ERK1/2 /MyD88 /p38 MAPK, JNK, iNOS/NO, and MMP pathways involved in imparting ameliorative effects in the therapy of neurodegenerative disorders and associated conditions. |
| doi_str_mv | 10.1002/ptr.7522 |
| format | Article |
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Considering, its low bioavailability, different curcumin analogs have been developed to afford desired pharmacokinetic profile and therapeutic outcome in varied pathological states. Several preclinical and clinical studies have indicated that curcumin ameliorates mitochondrial dysfunction, inflammation, oxidative stress apoptosis‐mediated neural cell degeneration and could effectively be utilized in the treatment of different neurodegenerative diseases. Hence, in this review, we have summarized key findings of experimental and clinical studies conducted on curcumin and its analogues with special emphasis on molecular pathways, viz. NF‐kB, Nrf2‐ARE, glial activation, apoptosis, angiogenesis, SOCS/JAK/STAT, PI3K/Akt, ERK1/2 /MyD88 /p38 MAPK, JNK, iNOS/NO, and MMP pathways involved in imparting ameliorative effects in the therapy of neurodegenerative disorders and associated conditions.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.7522</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>1-Phosphatidylinositol 3-kinase ; AKT protein ; Angiogenesis ; Apoptosis ; Bioavailability ; Central nervous system ; Curcuma longa ; Curcumin ; Degeneration ; Inflammation ; MAP kinase ; Mitochondria ; molecular pathways ; MyD88 protein ; Neurodegeneration ; Neurodegenerative diseases ; neuroinflammation ; Nitric-oxide synthase ; Oxidative stress ; Pharmacokinetics</subject><ispartof>Phytotherapy research, 2022-08, Vol.36 (8), p.3143-3180</ispartof><rights>2022 John Wiley & Sons Ltd.</rights><rights>2022 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3262-1a3c5f63a7d9603024fd0969a4d728992f2fa599ae5523ec5f1db2247f61513d3</citedby><cites>FETCH-LOGICAL-c3262-1a3c5f63a7d9603024fd0969a4d728992f2fa599ae5523ec5f1db2247f61513d3</cites><orcidid>0000-0003-3105-0759 ; 0000-0002-1524-7714 ; 0000-0003-2639-7096</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.7522$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.7522$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Joshi, Priyanka</creatorcontrib><creatorcontrib>Bisht, Akansha</creatorcontrib><creatorcontrib>Joshi, Sushil</creatorcontrib><creatorcontrib>Semwal, Deepak</creatorcontrib><creatorcontrib>Nema, Neelesh Kumar</creatorcontrib><creatorcontrib>Dwivedi, Jaya</creatorcontrib><creatorcontrib>Sharma, Swapnil</creatorcontrib><title>Ameliorating potential of curcumin and its analogue in central nervous system disorders and related conditions: A review of molecular pathways</title><title>Phytotherapy research</title><description>Curcumin, isolated from turmeric (Curcuma longa L.) is one of the broadly studied phytomolecule owing to its strong antioxidant and anti‐inflammatory potential and has been considered a promising therapeutic candidate in a wide range of disorders. 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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | 1-Phosphatidylinositol 3-kinase AKT protein Angiogenesis Apoptosis Bioavailability Central nervous system Curcuma longa Curcumin Degeneration Inflammation MAP kinase Mitochondria molecular pathways MyD88 protein Neurodegeneration Neurodegenerative diseases neuroinflammation Nitric-oxide synthase Oxidative stress Pharmacokinetics |
| title | Ameliorating potential of curcumin and its analogue in central nervous system disorders and related conditions: A review of molecular pathways |
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