Context‐specific roles of diphthamide deficiency in hepatocellular carcinogenesis

Diphthamide biosynthesis protein 1 (DPH1) is biochemically involved in the first step of diphthamide biosynthesis, a post‐translational modification of eukaryotic elongation factor 2 (EEF2). Earlier studies showed that DPH1, also known as ovarian cancer‐associated gene 1 (OVCA1), is involved in ovar...

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Veröffentlicht in:	The Journal of pathology 2022-10, Vol.258 (2), p.149-163
Hauptverfasser:	Tu, Wei‐Ling, Chih, Yu‐Chan, Shih, Ya‐Tung, Yu, Yi‐Ru, You, Li‐Ru, Chen, Chun‐Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Biosynthesis Carcinogenesis Cell cycle Diethylnitrosamine DPH1 eukaryotic elongation factor Fibrinogen Gene set enrichment analysis Genes Genomes Hepatocellular carcinoma Hepatocytes Liver cancer Mutants Organoids Ovarian cancer p53 Protein pericentral hepatocytes periportal progenitors Phenotypes Protein biosynthesis PTEN protein Translation elongation Tumors
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